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In memoriam pages 2073-2074 Full Text | Full-Text PDF (102 KB)
Introduction
New immunosuppressives and clinical studies: an embarrassment of riches or more toxicity management? R.D Guttmann pages 2079-2080 Full Text | Full-Text PDF (61 KB)
New mechanisms of action
Inhibition of costimulatory pathways for T-cell activation by 1,25-dihydroxyvitamin D3 G Penna, L Adorini pages 2083-2084 Full Text | Full-Text PDF (217 KB)
Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities M Feldmann, F Brennan, J Bondeson, E Paleolog, B Foxwell, R Maini pages 2085-2086 Full Text | Full-Text PDF (60 KB)
Mechanistic differences of cornerstone immunosuppressants
Overview of side effects of immunosuppressive therapy L.C Paul pages 2089-2091 Full Text | Full-Text PDF (68 KB)
Regulatory tolerance-mediating T cells in transplantation tolerance B Sawitzki, M Lehmann, T Ritter, E Graser, J.W Kupiec-Weglinski, H.D Volk pages 2092-2093 Full Text | Full-Text PDF (108 KB)
Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice C Gysemans, M Waer, J Laureys, R Bouillon, C Mathieu pages 2094-2095 Full Text | Full-Text PDF (62 KB)
New approaches
Bone marrow transplantation across major genetic barriers: the role of megadose stem cells and nonalloreactive donor anti-third party CTLS E Bachar-Lustig, S Reich-Zeliger, H Gur, Y Zhao, R Krauthgamer, Y Reisner pages 2099-2100 Full Text | Full-Text PDF (69 KB)
Cell cycle control and immunosuppression in organ transplantation A Khanna pages 2101-2106 Full Text | Full-Text PDF (768 KB)
Long-term tacrolimus: a promising therapeutic approach for Crohn’s disease E Ierardi, M Principi, R Francavilla, A Pisani, M Rendina, C Panella, A Francavilla pages 2107-2109 Full Text | Full-Text PDF (88 KB)
Mycophenolate mofetil interferes with interferon γ production in T-cell activation models K Izeradjene, L Quemeneur, M.C Michallet, N Bonnefoy-Berard, J.P Revillard pages 2110-2111 Full Text | Full-Text PDF (69 KB)
Brief communication I
Efficacy and safety of treatment with low-dose Fluvastatin in hypercholesterolemic renal transplant recipients T Akiyama, T Ishii, M Imanishi, T Nishioka, T Matsuura, T Kurita pages 2115-2118 Full Text | Full-Text PDF (155 KB)
Assessment of mechanisms of action of immunosuppressive drugs using novel whole blood assays M.J Barten, J.F Gummert, T van Gelder, R Shorthouse, R.E Morris pages 2119-2120 Full Text | Full-Text PDF (64 KB)
Mycophenolate Mofetil in the treatment of acute and chronic GVHD in hematopoietic stem cell transplant patients: four years of experience N Basara, M.G Kiehl, W Blau, E Römer, M Bischoff, B Schmetzer, D Kirsten, S Günzelmann, A.A Fauser pages 2121-2123 Full Text | Full-Text PDF (104 KB)
Comparison between tacrolimus and neoral cyclosporine administered by oral route in liver transplantation I Bilbao, L Pou, E Allende, J.L Lázaro, R Charco, E Hidalgo, C Margarit pages 2124-2126 Full Text | Full-Text PDF (71 KB)
Pharmacokinetics of tacrolimus primary immunosuppression in kidney transplant recipients F Braun, E Schütz, B Peters, R Talaulicar, C Grupp, N Undre, A Schäfer, V.W Armstrong, M Oellerich, B Ringe pages 2127-2128 Full Text | Full-Text PDF (67 KB)
Urinary retinol binding protein is a good marker of progressive cyclosporine nephrotoxicity after heart transplant N.O.S Camara, A.C.C Matos, D.A Rodrigues, A.B Pereira, A Pacheco-Silva pages 2129-2131 Full Text | Full-Text PDF (134 KB)
Apoptosis after in vitro allostimulation of umbilical cord blood J Chargui, T Hase, Y Watanabe, S Wada, R Yoshimura pages 2132-2133 Full Text | Full-Text PDF (64 KB)
Azithromycin treatment of gingival hyperplasia in kidney transplant recipients is effective and safe F Citterio, A Di Pinto, M.T Borzi, M.C Scatà, M Foco, U Pozzetto, M Castagneto pages 2134-2135 Full Text | Full-Text PDF (68 KB)
Sirolimus and erythromycin interaction: two cases K Claesson, C Brattström, J.T Burke page 2136 Full Text | Full-Text PDF (51 KB)
Modulation of human peripheral blood mononuclear cell activation by the combination of leflunomide and pentoxifylline Z Stojic Vukanic, M Dimitrijevic, M Colic, P Popovic, D Jandric pages 2137-2138 Full Text | Full-Text PDF (199 KB)
Dilitiazem reduces nitric oxide production by human immune cells A D’Ambrosio, E Giacomini, A Bachetoni, M.G Quaranta, F Quintieri pages 2139-2141 Full Text | Full-Text PDF (143 KB)
The immunosuppressant LF 15-0195 prevents collagen-induced arthritis with IL-10 down-regulation P Ducoroy, D de Fornel, F Chirade, P Fontet, P Dutartre pages 2142-2145 Full Text | Full-Text PDF (172 KB)
Low doses of mycophenolate mofetil with low doses of tacrolimus prevent acute rejection and long-term function loss after lung transplantation M.W Gerbase, A Spiliopoulos, M Fathi, L.P Nicod pages 2146-2147 Full Text | Full-Text PDF (87 KB)
High QT dispersion in tacrolimus-treated kidney transplant recipients U Gerhardt, B Suwelack, A Pawolka, H Hohage pages 2148-2150 Full Text | Full-Text PDF (81 KB)
Monoclonal anti-CD52 antibodies: a potential mode of therapy for parvovirus B19 hepatitis E Granot, H Miskin, M Aker pages 2151-2153 Full Text | Full-Text PDF (74 KB)
Trough level-guided mycophenolate mofetil rejection prophylaxis in liver transplantation B Grasser, F Iberer, S Schaffellner, D Kniepeiss, R Stauber, G Koshsorur, P Rehak, K.H Tscheliessnigg pages 2154-2156 Full Text | Full-Text PDF (98 KB)
Inhibition of TGF-β and VEGF expression in human endothelium cell lines with antisense-oligonucleotides: potential tools for gene therapy of chronic renal transplant rejection P Hallscheidt, R Wallich, G.W Kauffmann, S Pomer pages 2157-2159 Full Text | Full-Text PDF (1649 KB)
Involvement of interleukin-2 and growth factors in chronic kidney allograft rejection in rats P Hamar, A Szabó, V Müller, U Heemann pages 2160-2162 Full Text | Full-Text PDF (76 KB)
The value of routine monitoring of mycophenolic acid plasma levels after clinical heart transplantation C.J Hesse, P Vantrimpont, I.C van Riemsdijk-van Overbeeke, T van Gelder, A.H.M.M Balk, W Weimar pages 2163-2164 Full Text | Full-Text PDF (73 KB)
Chronic allograft nephropathy: a prospective randomised trial of cyclosporin reduction with or without mycophenolate mofetil S Jain, M Metcalfe, S.A White, P.N Furness, M.L Nicholson pages 2165-2166 Full Text | Full-Text PDF (60 KB)
Cyclosporine A metabolite AM19 as a potential biomarker in urine for CSA nephropathy M Kempkes-Koch, M Fobker, M Erren, C August, U Gerhardt, B Suwelack, H Hohage pages 2167-2169 Full Text | Full-Text PDF (98 KB)
Mycophenolate mofetil pharmacodynamics and pharmacokinetics correlate with rejection score in a BN-to-LEW heterotopic heart transplant model J Klupp, T van Gelder, C Dambrin, J Regieli, K Boeke, M.E Billingham, R.E Morris pages 2170-2171 Full Text | Full-Text PDF (63 KB)
New approach in drug development: whole blood pharmacodynamic assays reflect biological activities of tacrolimus J Klupp, C Dambrin, J Regieli, T van Gelder, R Shorthouse, R.E Morris page 2172 Full Text | Full-Text PDF (61 KB)
Anti-CD4-induced long-term acceptance of rat liver allografts in a high-responder model is not based on pure immunosuppression K Kohlhaw, U Sack, I Lehmann, G Drews, R Schwarz, T Hartwig, A Tannapfel, F Berr, M Oertel, U Marx, M Lehmann, C Witterkind, J Hauss, F Emmrich pages 2173-2175 Full Text | Full-Text PDF (315 KB)
Aspergillus infection in immunocompromised patients M Koselj-Kajtna, A Kandus, T Rott, S Zver, I Zupan, M Koselj, A Bren pages 2176-2178 Full Text | Full-Text PDF (68 KB)
Immunoablative therapy with autologous stem cell transplantation in the treatment of poor risk multiple sclerosis T Kozák, E Havrdová, J Pit’ha, E Gregora, R Pytlı́k, J Maaloufová, P Kobylka, S̆ Vodvár̆ková pages 2179-2181 Full Text | Full-Text PDF (73 KB)
Induction of immunologic tolerance to tetanus toxoid by anti-human CD4 in HLA-DR3+/human CD4+/murine CD4− multiple transgenic mice R Laub, M Dorsch, K Wenk, F Emmrich pages 2182-2183 Full Text | Full-Text PDF (66 KB)
Neointima suppression in rat carotid allografts by FTY720 combined with a small fixed cyclosporine dose is related to a diminution of the peripheral lymphocyte count Z Nikolova, R.P Hof pages 2184-2185 Full Text | Full-Text PDF (99 KB)
Long-term effects of ATG therapy on lymphocyte subsets L Martins, A Ventura, L Dias, A Henriques, A Sarmento, S Guimarães pages 2186-2187 Full Text | Full-Text PDF (88 KB)
Echographic valuation of risk factors for cardiovascular disease in patients with renal transplantation V Mazzarella, V Danese, F Pisani, O Buonomo, S Pollicita, F Rodio, S Cipriani, G Splendiani, G Simonetti, C.U Casciani pages 2188-2190 Full Text | Full-Text PDF (92 KB)
The effect of differing immunosuppressive regimes on the functional and morphologic changes in a rat renal allograft model of chronic rejection J.S McGrath, M Shehata pages 2191-2192 Full Text | Full-Text PDF (67 KB)
Chronic allograft nephropathy: prospective randomised trial of cyclosporin withdrawal and mycophenolate mofetil or tacrolimus substitution J.S McGrath, M Shehata pages 2193-2195 Full Text | Full-Text PDF (189 KB)
OKT3 versus methylprednisolone for primary treatment of rejection: a retrospective evaluation R.T Meijer, I Keur, S Surachno, I.J.M ten Berge, P.T.A Schellekens pages 2196-2197 Full Text | Full-Text PDF (63 KB)
New protocol and indication
Overview of clinical trials with new agents B Charpentier, Ch Hiesse, A Durrbach, M Ammor, F Von Ey, C Kechrid, F Kriaa pages 2201-2203 Full Text | Full-Text PDF (70 KB)
Procalcitonin: a new marker for diagnosis of acute rejection and nonviral infection of heart and lung transplant patients C Hammer, P Fraunberger, B Meiser, S Hammer pages 2204-2206 Full Text | Full-Text PDF (119 KB)
Tailoring immunosuppressive therapy based on donor and recipient risk factors M.R First pages 2207-2211 Full Text | Full-Text PDF (90 KB)
Topical immunomodulatory agents and their targets in inflammatory skin diseases A Wollenberg, T Bieber pages 2212-2216 Full Text | Full-Text PDF (340 KB)
Immunosuppressants-ligands as neuroprotectants J.S Kelly, J Sharkey pages 2217-2219 Full Text | Full-Text PDF (66 KB)
New immunosuppressants in BMT/GVHD N Basara, S Günzelmann, W Willenbacher, A.A Fauser, M.G Kiehl pages 2220-2222 Full Text | Full-Text PDF (73 KB)
Immunosuppression in ABO-incompatible transplantation P Mohacsi, R Rieben, U.E Nydegger pages 2223-2224 Full Text | Full-Text PDF (212 KB)
Immunosuppression in ANCA-associated vasculitis F.J van der Woude, W.H Schmitt, R Birck, R Nowack, U Göbel, J.M Drexler, O Hotta pages 2225-2226 Full Text | Full-Text PDF (60 KB)
Symposium session I
Efficacy of malononitrilamide 715 as immunosuppressant, alone or in combination with cyclosporin, in allogeneic foetal rat pancreatic transplantation C.J.F Muller, D.F duToit, B.J Page, N Muller, J Mattysen, R Lyners pages 2229-2231 Full Text | Full-Text PDF (383 KB)
Corticosteroid-free therapy after tacrolimus-based dual immunosuppression versus cyclosporine-based quadruple-induction therapy S Jonas, O Guckelberger, S.G Tullius, T Steinmüller, A.R Müller, O Grauhan, J.M Langrehr, W.O Bechstein, P Neuhaus pages 2232-2233 Full Text | Full-Text PDF (106 KB)
Monitoring of ATG therapy by flow cytometry: comparison of one single-platform and two different dual-platform methods B Reckzeh, S.O Grebe, I Rhiele, A Neubauer, T.F Müller pages 2234-2236 Full Text | Full-Text PDF (110 KB)
Graft-versus-host disease-like features in mycophenolate mofetil-related colitis J.C Papadimitriou, C.B Drachenberg, C.O Beskow, C Cangro, A Wiland, D Klassen, M Weir, S Bartlett pages 2237-2238 Full Text | Full-Text PDF (60 KB)
T-cell reactivity during azathioprine therapy compared with mycophenolate mofetil therapy N.M van Besouw, B.J van der Mast, P de Kuiper, P.J.H Smak Gregoor, L.M.B Vaessen, J.N.M IJzermans, T van Gelder, W Weimar pages 2239-2240 Full Text | Full-Text PDF (61 KB)
Cyclosporine A downregulates intragraft platelet-derived growth factor-α mRNA expression after clinical heart transplantation H.A de Groot-Kruseman, C.C Baan, W.M Mol, H.G.M Niesters, A.P.W.M Maat, A.H.M.M Balk, W Weimar pages 2241-2243 Full Text | Full-Text PDF (100 KB)
IL-7 and IL-15 bypass the immunosuppressive action of anti-CD25 monoclonal antibodies C.C Baan, M.J.A.M Boelaars-van Haperen, I.C van Riemsdijk, A.J van der Plas, W Weimar pages 2244-2246 Full Text | Full-Text PDF (370 KB)
Tacrolimus: a new immunosuppressant for steroid refractory inflammatory bowel disease K Fellermann, K.R Herrlinger, T Witthoeft, N Homann, D Ludwig, E.F Stange pages 2247-2248 Full Text | Full-Text PDF (61 KB)
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