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Special welcome message from the president Oscar Salvatierra page 9 Full Text | Full-Text PDF (60 KB)
Welcome message from Rome Raffaello Cortesini page 11 Full Text | Full-Text PDF (54 KB)
In fond remembrance: Dario Alfani Oscar Salvatierra page 13 Full Text | Full-Text PDF (142 KB)
In memoriam: Keith Reemtsma plenary session on xenotransplantation Judy Reemtsma page 14 Full Text | Full-Text PDF (48 KB)
Speech by Raffaello Cortesini, Congress Chairman Raffaello Cortesini pages 27-28 Full Text | Full-Text PDF (143 KB)
Special address by His Holiness John Paul II, Rome, August 29, 2000 pages 31-32 Full Text | Full-Text PDF (65 KB)
Presidential address Oscar Salvatierra pages 33-44 Full Text | Full-Text PDF (1098 KB)
The 2000 Medawar prize Oscar Salvatierra page 45 Full Text | Full-Text PDF (48 KB)
Transplantation in the new millenium R. Cortesini pages 47-48 Full Text | Full-Text PDF (63 KB)
Frontiers in transplantation
Strategies for induction of clinical tolerance A.P Monaco pages 51-56 Full Text | Full-Text PDF (88 KB)
Recombinant antigens to establish a model of autoimmunity in mice G. Del Pozzo, G. Bonomi, F. Moschella, P. Barba, P. De Berardinis, J. Guardiola page 57 Full Text | Full-Text PDF (54 KB)
Induction of transplantation tolerance by 1,25-dihydroxyvitamin D3 L Adorini, G Penna, M Casorati, A.M Davalli, S Gregori pages 58-59 Full Text | Full-Text PDF (142 KB)
Immunobiology of human NK cells L. Moretta, R. Biassoni, C. Bottino, M.C. Mingari, A. Moretta pages 60-61 Full Text | Full-Text PDF (61 KB)
Hepatocyte transplantation: an experimental study to treat acute liver failure in pigs G Ambrosino, S Varotto, S Basso, M Bettiol, A Cecchetto, P Carraro, A Naso, F Lumachi, G De Silvestro, M Plebani, G Davia, G Abatangelo, D D’amico pages 62-65 Full Text | Full-Text PDF (251 KB)
Engineered vessels: importance of the extracellular matrix A Solan, V Prabhakar, L Niklason pages 66-68 Full Text | Full-Text PDF (977 KB)
Immunobiology and experimental transplantation: immunoregulatory mechanisms
Megadose approach to DBMC infusion-induced allograft hyporesponsiveness in living-related renal allograft recipients H.L Trivedi, V.R Shah, P.R Shah, A.S Sane, A.V Vanikar, V.B Trivedi, S Velusami, K Narayanan, S.S Dalal, N.C Pancholy, S.A Shah, T.P Shah, K.V Visana pages 71-76 Full Text | Full-Text PDF (611 KB)
Induction of kidney allograft tolerance through mixed chimerism in miniature swine Y Fuchimoto, C.A Huang, K Yamada, Z.L Gleit, H Kitamura, A Griesemer, R Scheier-Dolberg, E Melendy, M.E White-Scharf, D.H Sachs page 77 Full Text | Full-Text PDF (54 KB)
Organ allograft recipients develop HLA class I-specific T suppressor cells P Bruzzone, E Renna Molajoni, P Cinti, B Evangelista, D Peritore, L Poli, R Pretagostini, P Berloco, R Cortesini, N.Suciu Foca Cortesini pages 78-79 Full Text | Full-Text PDF (65 KB)
Intrathymic immune regulation with donor class I allopeptides leads to the development of immunoregulatory cells that maintain tolerance to cardiac allografts H Shirwan, A Mhoyan, E Yolcu, S Ibrahim page 80 Full Text | Full-Text PDF (59 KB)
Oral antigen induces allograft survival by linked suppression via the indirect pathway M Niimi, N Shirasugi, Y Ikeda, K.J Wood page 81 Full Text | Full-Text PDF (59 KB)
CD8+CD28− T cells suppress alloresponse of CD4+ T cells both in primates and rodents Z Liu, B Yu, J Fan, R Cortesini, N Suciu-Foca pages 82-83 Full Text | Full-Text PDF (76 KB)
Suppression of alloimmune responses in vitro and in vivo by CD3+CD8−CD4−αβ+ regulatory T cells Z.-X Zhang, L Yang, K.J Young, L Zhang pages 84-85 Full Text | Full-Text PDF (162 KB)
Intratracheal delivery of alloantigen induces donor-specific hyporesponsiveness: dendritic cells play a pivotal role as regulatory cells N Shirasugi, Y Akiyama, Y Ikeda, S Kan, K Hamano, H Takami, S Kodaira, M Niimi page 86 Full Text | Full-Text PDF (58 KB)
Specific suppression of proliferative responses by primed lymphocytes of tolerant miniature swine A Wu, F.L Ierino, K Yamada, D.H Sachs page 87 Full Text | Full-Text PDF (52 KB)
CTLA4Ig-induced linked regulation of allogeneic T cell responses R.S Lee, J.R Rusche, M.E Maloney, D.H Sachs, M.H Sayegh, J.C Madsen pages 88-89 Full Text | Full-Text PDF (112 KB)
TCR transgenic regulatory T cells prevent lethal graft-versus-host disease Y Sorge, P Ostermann, B Bayer, J Klempnauer, M.W Hoffmann pages 90-91 Full Text | Full-Text PDF (68 KB)
Mechanisms of acquired tolerance induced by adoptive transfer of MHC-specific alloreactive T cells: effector T cells migrate to the thymus R Gopinathan, H.A DePaz, O.O Oluwole, K Engelstad, A.O Ali, M Garrovillo, R.A Fawwaz, T.S.T Wang, M.A Hardy, S.F Oluwole page 92 Full Text | Full-Text PDF (57 KB)
Autoimmune responses regulate alloimmunity for prolonged cardiac allograft survival E Yolcu, J Fang, H Shirwan page 93 Full Text | Full-Text PDF (59 KB)
CD8α+ (lymphoid-related) and CD8α− (myeloid) dendritic cells differentially regulate vascularized organ allograft survival P.J O’Connell, W Li, T Takayama, A.J Logar, S Qian, A.W Thomson page 94 Full Text | Full-Text PDF (68 KB)
Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts R.A Kirken, R Erwin-Cohen, F Behbod, M.-E Wang, S.M Stepkowski, B.D Kahan page 95 Full Text | Full-Text PDF (58 KB)
Thymic recognition of AlloMHC peptide-primed alloreactive T cells induces specific unresponsiveness to islets O.O Oluwole, H.A DePaz, R Gopinathan, M.X Jin, A.O Ali, M.A Hardy, S.F Oluwole page 96 Full Text | Full-Text PDF (56 KB)
Induction of acquired tolerance to cardiac allografts by adoptive transfer of in vivo allopeptide activated T cells A.O Ali, M Garrovillo, O.O Oluwole, H.A DePaz, R Gopinathan, M.A Hardy, S.F Oluwole page 97 Full Text | Full-Text PDF (56 KB)
In utero induction of transplantation tolerance D.W Mathes, K Yamada, M.A Randolph, R Utsugi, M.G Solari, G.S Gazelle, A Wu, D.H Sachs, W.P.A Lee pages 98-100 Full Text | Full-Text PDF (112 KB)
Tolerance across a two-haplotype, fully MHC-mismatched barrier induced in miniature swine renal allografts treated with a 12-day course of tacrolimus R Utsugi, R.N Barth, H Kitamura, J Ambroz, D.H Sachs, K Yamada page 101 Full Text | Full-Text PDF (56 KB)
Liver transplants induce deletion of liver-specific T cells S Celli, P Matzinger pages 102-103 Full Text | Full-Text PDF (70 KB)
CD8+CD28− T suppressor cells represent a distinct subset in a heterogeneous population A.I Colovai, R Ciubotariu, Z Liu, R Cortesini, N Suciu-Foca pages 104-107 Full Text | Full-Text PDF (421 KB)
Donor bone marrow cells used for the induction of allograft acceptance in clinical transplantation as regulators of autologous immune responses J.M Mathew, L Fuller, M Carreno, G.W Burke, G Ciancio, C Ricordi, A.G Tzakis, V Esquenazi, J Miller pages 108-109 Full Text | Full-Text PDF (72 KB)
Immunobiology and experimental transplantation: chimerism
Intrathymic donor stem cell fractions increase chimerism but do not check alloantibody or alloreactivity responses in nonhuman primates Y Nitta, L.K Gaur, K Nelson, R de Fries-Hallstrand, R Thomas, R.G Andrews, M.D Allen pages 110-111 Full Text | Full-Text PDF (62 KB)
Essential role of MHC class II antigens in tolerance induction in allogeneic radiation chimera A Umemura, A.P Monaco, T Maki page 112 Full Text | Full-Text PDF (57 KB)
Inhibition of in vitro donor-specific proliferative and cytotoxic T cell responses in chimeric CD40 ligand-deficient bone marrow transplant recipients treated perioperatively with CTLA4-Ig J.E Woodward, A.T Schaefer, L.B Zottola, J.K Stazer, A.J Logar, R Peach, A.S Rao pages 113-114 Full Text | Full-Text PDF (68 KB)
Blockade of the CD28/B7 pathway is required for the establishment of donor cell chimerism in CD40 ligand-deficient recipients J.E Woodward, L.B Zottola, A.T Schaefer, A.J Logar, J.K Stazer, T Daskivich, R Peach, A.S Rao page 115 Full Text | Full-Text PDF (64 KB)
Comparison of horse antithymocyte globulin with other T cell-depleting antibodies for induction of chimerism and renal allograft tolerance in nonhuman primates H Sogawa, T Kawai, S.L Wee, S Boskovic, O Nadazdin, J Phelan, G Abrahamian, D.S.C Ko, H Hong, S Mauiyyedi, R.B Colvin, D.H Sachs, A.B Cosimi pages 116-117 Full Text | Full-Text PDF (63 KB)
Mixed chimerism using a nonmyelosuppressive regimen in miniature swine Y Fuchimoto, C.A Huang, Z.L Gleit, H Kitamura, A Griesemer, E Melendy, R Scheier-Dolberg, M.E White-Scharf, D.H Sachs pages 118-119 Full Text | Full-Text PDF (62 KB)
Mixed bone marrow chimerism as a treatment for autoimmune diabetes I Leykin, B Nikolic, M Sykes page 120 Full Text | Full-Text PDF (55 KB)
Heart allograft tolerance without development of posttransplant cardiac allograft vasculopathy in cyclophosphamide-induced tolerance I Shimizu, Y Tomita, T Iwai, Q.-W Zhang, Y Nakashima, K Sueishi, H Yasui pages 121-126 Full Text | Full-Text PDF (480 KB)
Cells of donor phenotype present in renal transplant recipients infused with donor marrow: potent regulators of antidonor immune responses of the recipient J.M Mathew, R Garcia-Morales, L Fuller, A Rosen, G.W Burke, G Ciancio, M Carreno, C Ricordi, A.G Tzakis, V Esquenazi, J Miller pages 127-128 Full Text | Full-Text PDF (73 KB)
Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts T Miki, H Sun, Y-H Lee, A Tandin, A.M Kovscek, V Subbotin, J.J Fung, L.A Valdivia pages 129-130 Full Text | Full-Text PDF (101 KB)
Immunobiology and experimental transplantation: tolerance induction
Tolerance induction by alteration of T cell receptor (TCR) signaling using an allochimeric donor/recipient class I MHC protein S.M Stepkowski, R.A Kirken, M Wang, J Yu, K Akioka, B.D Kahan page 131 Full Text | Full-Text PDF (59 KB)
Modulation of primary T cell responses and tolerance induction by tyrphostin AG490 M.D Säemann, C Diakos, G Staffler, G.A Böhmig, C.H Österreicher, H Stockinger, G.J Zlabinger pages 132-133 Full Text | Full-Text PDF (89 KB)
Mechanism of adenoviral-mediated CTLA4-IG gene-induced pancreatic allograft tolerance in rats C Liu, S Deng, K Jiang, A Gelman, A Shaked, K.L Brayman page 134 Full Text | Full-Text PDF (56 KB)
Donor cell migration and graft-infiltrating cell apoptosis in heart acceptance in a multiorgan transplant model C Wang, J Sun, M Horvat, N Koutalistras, A.G.R Sheil page 135 Full Text | Full-Text PDF (58 KB)
Mechanisms underlying the immunosuppressive activity of antitransferrin receptor monoclonal antibody X Li, L Cicalese, M DeMasi, E Benedetti, C Rastellini page 136 Full Text | Full-Text PDF (61 KB)
Graft acceptance and tolerance induction in mouse liver transplantation using wild mice A Sugioka, M Morita, J Fujita, A Hasumi, T Shiroishi pages 137-139 Full Text | Full-Text PDF (506 KB)
The role of CD30 in skin and heart allograft rejection in the mouse J Beckmann, C Kurts, I Klebba, B Bayer, J Klempnauer, M.W Hoffmann pages 140-141 Full Text | Full-Text PDF (64 KB)
Features of tolerance achieved by antigen and a single injection of an anti-CD45 monoclonal antibody in rats M.D Jäger, T.-Y Tsui, H Aselmann, M.H Dahlke, A Deiwick, M Neipp, J Klempnauer, K Wonigeit, H.J Schlitt page 142 Full Text | Full-Text PDF (63 KB)
Portal venous tolerance in the anti–class I Ld alloantigen 2C transgenic mouse J.A Margenthaler, S Yu, N Otomo, Y Shimizu, M.W Flye pages 143-144 Full Text | Full-Text PDF (69 KB)
Nihility: discovery of the immunologic zero corner where self-tolerance and clonal deletion are challenged Z.K. Chen pages 145-147 Full Text | Full-Text PDF (184 KB)
Expression of MHC class II antigen is essential in tolerance induction by donor bone marrow cell in antilymphocyte serum–treated and rapamycin-treated mice A Umemura, A.P Monaco, T Maki page 148 Full Text | Full-Text PDF (57 KB)
Regulatory role of the thymic dendritic cells in acquired thymic tolerance: induction of tolerance to cardiac allografts by adoptive transfer of allopeptide-pulsed host thymic dendritic cells M Garrovillo, A.O Ali, H.A DePaz, R Gopinathan, O.O Oluwole, M.A Hardy, S.F Oluwole page 149 Full Text | Full-Text PDF (53 KB)
Donor-specific antigen transfusion-mediated cardiac allograft tolerance is prevented by prior treatment with anti-CD8, but not anti-CD4, antibody Y Shimizu, N Otomo, S Yu, J.A Margenthaler, M.W Flye pages 150-151 Full Text | Full-Text PDF (70 KB)
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