Donation, allocation, and ischemic reperfusion injuryCurrent Status of the Scandiatransplant Acceptable Mismatch Program
Section snippets
Methodology
The data used in this study were extracted from the Scandiatransplant database, which covers a wide range of organ donors, recipients, and follow-up information. Scandiatransplant has a decentralized organization with a small central office that takes care of developments and maintains the database. The data input depends on the users of the database at each transplantation center within Scandiatransplant. A variety of quality controls on the data registrations are performed by the central
Description of STAMP
The program seeks to extend recipients having given HLA types with all acceptable HLA mismatches including splits of HLA-A, B, C, DR, and DQ alleles. When kidneys from a deceased donor are available a search for suitable recipients among all the Nordic actively waiting subjects is performed using the Scandiatransplant database. Table 1 illustrates where adding acceptable mismatches increased the number of acceptable antigens significantly. This procedure increases the likelihood to find a
Discussion
The STAMP program is up and running; several highly immunized kidney recipients have undergone successful transplantation and waiting times have been reduced. Because the data are still limited and the observation times in many cases are short, we need a closer, more detailed follow-up. However, the transplantation results were acceptable; alternatives must be used for recipients to address the marginally improved probability of transplantation and long waiting times on STAMP.
After the program
Acknowledgments
The collaboration with the STAMP steering committee (Bjarne Møller, Mats Bengtson, Jouni Lauronen, Christian Naper, Torbjørn Leivestad [former member of the STAMP committee]), Lars Wennberg, and Lauri Kyllönen) is greatly appreciated. The work made by the rest of the team at the Scandiatransplant office (Christian Mondrup, Bo H. Pedersen, Susanne Sønder, Camilla Pedersen, and Tito Phiri) is gratefully acknowledged. Transplantation coordinators, laboratory technicians, secretaries, nurses, and
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