Transplantation Proceedings
Volume 43, Issue 10 , Pages 3573-3576 , December 2011

Repairing the Chronic Damaged Kidney: The Role of Regenerative Medicine

  • H.C. Caldas

      Affiliations

    • Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School, FAMERP/FUNFARME, Hospital de Base, Sao Jose Rio Preto, Brazil
  • ,
  • A.P.C. Hayashi

      Affiliations

    • Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School, FAMERP/FUNFARME, Hospital de Base, Sao Jose Rio Preto, Brazil
  • ,
  • M. Abbud-Filho

      Affiliations

    • Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School, FAMERP/FUNFARME, Hospital de Base, Sao Jose Rio Preto, Brazil
    • Department of Medicine, Division of Nephrology, Medical School, FAMERP/FUNFARME, Hospital de Base, Sao Jose Rio Preto, Brazil
    • Corresponding Author InformationAddress reprint requests to Mario Abbud Filho, MD, PhD, Department of Medicine/Nephrology, Laboratory of Immunology and Transplantation Experimental-LITEX, Av Brigadeiro Faria Lima 5416-15090-000, Sao Jose do Rio Preto, SP, Brazil

References 

  1. Little MH . Regrow or repair: potential regenerative therapies for the kidney . J Am Soc Nephrol . 2006;17:2390
  2. Abdi R , Fiorina P , Adra CN , et al.  Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes . Diabetes . 2008;57:1759
  3. da Silva Meirelles L , Caplan AI , Nardi NB . In search of the in vivo identity of mesenchymal stem cells . Stem Cells . 2008;26:2287
  4. Patel SA , Sherman L , Munoz J , et al.  Immunological properties of mesenchymal stem cells and clinical implications . Arch Immunol Ther Exp . 2008;56:1
  5. Nauta AJ , Fibbe WE . Immunomodulatory properties of mesenchymal stromal cells . Blood . 2007;110:3499
  6. Kode A , Mukherjee S , Joglekar MV , et al.  Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration . Cytotherapy . 2009;11:377
  7. Aggarwal S , Pittenger MF . Human mesenchymal stem cells modulate allogeneic immune cell responses . Blood . 2005;105:1815
  8. Corcione A , Benvenuto F , Ferretti E , et al.  Human mesenchymal stem cells modulate B-cell functions . Blood . 2006;107:367
  9. Anglani F , Forino M , Del Prete D , et al.  In search of adult renal stem cells . J Cell Mol Med . 2004;8:474
  10. Abbate M , Brown D , Bonventre JV . Expression of NCAM recapitulates tubulogenic development in kidneys recovering from acute ischemia . Am J Physiol . 1999;277:454
  11. Mollura DJ , Hare JM , Rabb H . Stem-cell therapy for renal diseases . Am J Kidney Dis . 2003;42:891
  12. Mattoli S , Bellini A , Schmidt M . The role of a human hematopoietic mesenchymal progenitor in wound healing and fibrotic diseases and implications for therapy . Curr Stem Cell Res Ther . 2009;4:266
  13. Romagnani P , Kalluri R . Possible mechanisms of kidney repair . Fibrogenesis Tissue Repair . 2009;26:3
  14. Tögel F , Hu Z , Weiss K , et al.  Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms . Am J Physiol Renal Physiol . 2005;289:31
  15. Kalluri R , Weinberg RA . The basics of epithelial-mesenchymal transition . J Clin Invest . 2009;119:1420
  16. Kalluri R , Neilson EG . Epithelial-mesenchymal transition and its implications for fibrosis . J Clin Invest . 2003;112:1776
  17. Nangaku M , Fujita T . Activation of the renin-angiotensin system and chronic hypoxia of the kidney . Hypertens Res . 2008;31:175
  18. Ninichuk V , Gross O , Segerer S , et al.  Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4α3-deficient mice . Kidney Int . 2006;70:121
  19. Hostetter TH . Progression of renal disease and renal hypertrophy . Annu Rev Physiol . 1995;57:263
  20. Griffin KA , Picken M , Bidani AK . Method of renal mass reduction is a critical modulator of subsequent hypertension and glomerular injury . J Am Soc Nephrol . 1994;4:2023
  21. Santos LS , Chin EW , Ioshii SO , et al.  Surgical reduction of the renal mass in rats: morphologic and functional analysis on the remnant kidney . Acta Cir Bras . 2006;21:252
  22. Fujihara CK , Lourdes Noronha I , Malheiros DMAC , et al.  Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney . J Am Soc Nephrol . 2000;11:283
  23. Choi SJ , Kim JK , Hwang SD . Mesenchymal stem cell therapy for chronic renal failure . Expert Opin Biol Ther . 2010;10:1217
  24. Kunter U , Rong S , Djuric Z , et al.  Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis . J Am Soc Nephrol . 2006;17:2202
  25. Zerbini G , Piemonti L , Maestroni A , et al.  Stem cells and the kidney: a new therapeutic tool . J Am Soc Nephrol . 2006;17:123
  26. Caldas HC , Fernandes IMM , Gerbi F , et al.  Effect of whole bone marrow cell infusion in the progression of experimental chronic renal failure . Transplant Proc . 2008;40:853
  27. Cavaglieri RC , Martini D , Sogayar MC , et al.  Mesenchymal stem cells delivered at the subcapsule of the kidney ameliorates renal disease in the rat remnant kidney model . Transplant Proc . 2009;41:947
  28. Semedo P , Correa-Costa M , Antonio Cenedeze M , et al.  Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model . Stem Cells . 2009;27:3063
  29. Choi S , Park M , Kim J , et al.  The role of mesenchymal stem cells in the functional improvement of chronic renal failure . Stem Cells Dev . 2009;18:521
  30. Alexandre CS , Volpini RA , Shimizu MH , et al.  Lineage-negative bone marrow cells protect against chronic renal failure . Stem Cells . 2009;27:682
  31. Caldas HC , Fernandes IM , Kawasaki-Oyama RS , et al.  Effect of stem cells seeded onto biomaterial on the progression of experimental chronic kidney disease . Exp Biol Med . 2011;236:746
  32. Macchiarini P , Jungebluth P , Go T , et al.  Clinical transplantation of a tissue-engineered airway . Lancet . 2008;13:2023
  33. Atala A , Bauer SB , Soker S , et al.  Tissue-engineered autologous bladders for patients needing cystoplasty . Lancet . 2006;367:1241
  34. Pachence JM . Collagen-based devices for soft tissue repair . J Biomed Mater Res . 1996;33:35
  35. Lee CH , Singla A , Lee Y . Biomedical applications of collagen . Int J Pharm . 2001;221:1
  36. Fan VH , Tamama K , Au A , et al.  Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells . Stem Cells . 2007;25:1241
  37. Chiu LL , Radisic M . Scaffolds with covalently immobilized VEGF and angiopoietin-1 for vascularization of engineered tissues . Biomaterials . 2010;31:226
  38. Nakayama KH , Batchelder CA , Lee CI , et al.  Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering . Tissue Eng . 2010;16:2207
  39. Ross EA , Williams MJ , Hamazaki T , et al.  Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds . J Am Soc Nephrol . 2009;20:2338
  40. Rosines E , Johkura K , Zhang X , et al.  Constructing kidney-like tissues from cells based on programs for organ development: towards a method of in vitro engineering of the kidney . Tissue Eng . 2010;16:2441

PII: S0041-1345(11)01530-2

doi: 10.1016/j.transproceed.2011.10.053

Transplantation Proceedings
Volume 43, Issue 10 , Pages 3573-3576 , December 2011