Bone marrow transplantationPredictive Value of Immature Reticulocyte and Platelet Fractions in Hematopoietic Recovery of Allograft Patients
Section snippets
Patients
Between January 2008 and July 2009, we studied 46 adult patients with hematologic malignancies who underwent allogeneic PBPC transplant: 37 related and 9 unrelated grafts. The diagnoses were: acute leukemia (n = 18), chronic myeloid leukemia (n = 4), non-Hodgkin lymphoma (n = 6), multiple myeloma (n = 4), myelodysplasia (n = 6) and other malignancies (n = 8). The conditioning regimen was myeloablative in most cases (n = 29) versus nonmyeloablative (n = 17). All patients signed informed consent
Results
Preconditioning hematologic parameters were used for comparisons with values at days 0 and serially after transplantation (Fig 1). According to established protocols, on day 0 patients received 5.1 × 106 CD34+ cells/kg recipient (range, 1.9–7.3). On this day the median values of classic hematologic parameters were 2.7 × 109/L for leukocytes, 2.3 × 109/L for neutrophils, and 70 × 109/L for platelets. The kinetics of patient recovery was recorded during the hospitalization period (Fig 1).
In this
Discussion
Cellular immaturity fractions predicted the hematopoietic recovery of patients after PBPC transplantation. For allotransplanted patients after NMA regimens the prediction was even more noteworthy and clinically relevant.
Evaluation of these fractions could help with monitoring of patients' transfusional support throughout posttransplant recovery. Better management of blood components avoids alloimmunization and reduces costs. These immaturity fractions open new perspectives in patient follow-up
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2020, Complementary Therapies in MedicineCitation Excerpt :The present study showed that DBT could increase the ratio of reticulocytes in peripheral blood of mice. Reticulocytes are an important indicator of haematopoiesis in the bone marrow.18 Meanwhile, DBT could increase the ratio of erythroid-related cells, early erythroid-related cells and medium erythroid-related cells in the bone marrow.
Automated blood cell analysis
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Clinical Utility of Reticulocyte Parameters
2015, Clinics in Laboratory MedicineClinical applicability of reticulated platelets
2014, Clinica Chimica ActaCitation Excerpt :They concluded that RP count was a powerful tool to assess bone marrow recovery post-operatively. Currently, the evaluation criteria for hematopoietic recovery after allogeneic marrow transplantation include a neutrophil count greater than 0.5 × 109/L (three consecutive days) and a platelet count above 20 × 109/L (seven consecutive days) [51]. Michur et al. [52], observed that increased RP paralleled these parameters suggesting its usefulness post-transplantation.
A.P. Gonçalo and I.L. Barbosa contributed equally to this work.