Transplantation Proceedings
Volume 42, Issue 6 , Pages 1999-2002 , July 2010

Similar Early Complication Rate in Simultaneous Pancreas and Kidney Recipients on Tacrolimus/Mycophenolate Mofetil Versus Tacrolimus/Sirolimus Immunosuppressive Regimens

  • P. Girman

      Affiliations

    • Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    • Corresponding Author InformationAddress reprint requests to Peter Girman, MD, PhD, Diabetes Center, Institute for Clinical and Experimental Medicine, 14021 Prague; Videnska 1958/9, Czech Republic
  • ,
  • K. Lipar

      Affiliations

    • Transplantation Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  • ,
  • R. Koznarova

      Affiliations

    • Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  • ,
  • P. Boucek

      Affiliations

    • Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  • ,
  • J. Kriz

      Affiliations

    • Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  • ,
  • M. Kocik

      Affiliations

    • Transplantation Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  • ,
  • T. Havrdova

      Affiliations

    • Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  • ,
  • M. Adamec

      Affiliations

    • Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  • ,
  • F. Saudek

      Affiliations

    • Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

References 

  1. Stratta RJ. Surgical nuances in pancreas transplantation. Transplant Proc. 2005;37:1291
  2. Bindi ML, Biancofiore G, Meacci L, et al. Early morbidity after pancreas transplantation. Transpl Int. 2005;18:1356
  3. Gruessner AC, Sutherland DE. Pancreas transplant outcomes for United States (US) cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR). Clin Transpl. 2008;45:
  4. Schena FP, Pascoe MD, Alberu J, et al. Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. Transplant. 2009;87:233
  5. Dean PG, Lund WJ, Larson TS, et al. Wound-healing complications after kidney transplantation: a prospective, randomized comparison of sirolimus and tacrolimus. Transplant. 2004;77:1555
  6. Arbogast H, Malaise J, Illner WD, et al. Rejection after simultaneous pancreas-kidney transplantation. Nephrol Dial Transplant. 2005;20(suppl 2):ii11
  7. Steurer W, Malaise J, Mark W, et al. Spectrum of surgical complications after simultaneous pancreas-kidney transplantation in a prospectively randomized study of two immunosuppressive protocols. Nephrol Dial Transplant. 2005;20(suppl 2):ii54
  8. Malaise J, De Roover A, Squifflet JP, et al. Immunosuppression in pancreas transplantation: the Euro SPK trials and beyond. Acta Chir Belg. 2008;108:673
  9. Teutonico A, Schena PF, Di Paolo S. Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus. J Am Soc Nephrol. 2005;16:3128
  10. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:230
  11. Phung TL, Ziv K, Dabydeen D, et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell. 2006;10:159
  12. Troppmann C, Pierce JL, Gandhi MM, et al. Higher surgical wound complication rates with sirolimus immunosuppression after kidney transplantation: a matched-pair pilot study. Transplant. 2003;76:426
  13. Berney T, Secchi A. Rapamycin in islet transplantation: friend or foe?. Transpl Int. 2009;22:153
  14. Gruessner AC, Sutherland DE. Pancreas transplant outcomes for United States (US) and non-US cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of October 2002. Clin Transpl. 2005;41:2002
  15. Benedetti E, Gruessner AC, Troppmann C, et al. Intra-abdominal fungal infections after pancreatic transplantation: incidence, treatment, and outcome. J Am Coll Surg. 1996;183:307
  16. Stratta RJ, Shokouh-Amiri MH, Egidi MF, et al. A prospective comparison of simultaneous kidney-pancreas transplantation with systemic-enteric versus portal-enteric drainage. Ann Surg. 2001;233:740
  17. Sandrini S, Setti G, Bossini N, et al. Steroid withdrawal five days after renal transplantation allows for the prevention of wound-healing complications associated with sirolimus therapy. Clin Transplant. 2009;23:16
  18. Burke GW, Gaynor JJ, Sageshima J, et al. Lower rate of acute rejection with rapamycin vs mycophenolate mofetil in simultaneous pancreas-kidney transplanta recipients: 8-year follow-up. CG Xenotransplant. 2009;16:400

 Supported by grant MZO 00023001.

PII: S0041-1345(10)00786-4

doi: 10.1016/j.transproceed.2010.05.121

Transplantation Proceedings
Volume 42, Issue 6 , Pages 1999-2002 , July 2010