Transplantation Proceedings
Volume 42, Issue 6 , Pages 2011-2015 , July 2010

Pancreas Oxygen Persufflation Increases ATP Levels as Shown by Nuclear Magnetic Resonance

  • W.E. Scott III

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • B.P. Weegman

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • J. Ferrer-Fabrega

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • S.A. Stein

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • T. Anazawa

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • V.A. Kirchner

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • M.D. Rizzari

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • Department of Surgery, University of Texas Southwestern, Dallas, Texas, USA
    • ,
  • J. Stone

      Affiliations

    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • S. Matsumoto

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • B.E. Hammer

      Affiliations

    • Department of Radiology, Center for Interdisciplinary Applications in Magnetic Resonance, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • A.N. Balamurugan

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • L.S. Kidder

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • T.M. Suszynski

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • E.S. Avgoustiniatos

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • S.G. Stone

      Affiliations

    • Giner Inc., Newton, Massachusetts
    • ,
  • L.A. Tempelman

      Affiliations

    • Giner Inc., Newton, Massachusetts
    • ,
  • D.E.R. Sutherland

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • B.J. Hering

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • K.K. Papas

      Affiliations

    • Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA
    • Corresponding Author InformationAddress reprint requests to Klearchos K. Papas, PhD, Schulze Diabetes Institute, University of Minnesota Medical School, Mayo Mail Code 195, 420 Delaware St SE, Minneapolis, MN 55455

References 

  1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:289
  2. Shapiro AM, Ricordi C, Hering B. Edmonton's islet success has indeed been replicated elsewhere. Lancet. 2003;362(9391):1242
  3. Hiraoka K, Kuroda Y, Suzuki Y, et al. Outcomes in clinical pancreas transplantation with the two-layer cold storage method versus simple storage in University of Wisconsin solution. Transplant Proc. 2002;34:2688
  4. Tsujimura T, Kuroda Y, Avila JG, et al. Influence of pancreas preservation on human islet isolation outcomes: impact of the two-layer method. Transplantation. 2004;78:96
  5. Matsumoto S, Zhang G, Qualley S, et al. The effect of two-layer (University of Wisconsin solution/perfluorochemical) preservation method on clinical grade pancreata prior to islet isolation and transplantation. Transplant Proc. 2004;36:1037
  6. Tsujimura T, Kuroda Y, Avila JG, et al. Resuscitation of the ischemically damaged human pancreas by the two-layer method prior to islet isolation. Transplant Proc. 2003;35:2461
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  9. Avgoustiniatos ES, Hering BJ, Papas KK. The rat pancreas is not an appropriate model for testing the preservation of the human pancreas with the two-layer method. Transplantation. 2006;81:1471
  10. Papas KK, Hering BJ, Guenther L, et al. Pancreas oxygenation is limited during preservation with the two-layer method. Transplant Proc. 2005;38:3501
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  12. Caballero-Corblan J, Eich T, Foss A, et al. No beneficial effect of the two layer method (PFCUW) compared with transportation in UW alone on the outcome of human islet isolation and transplantation: a report on 214 human pancreases. Am J Transplant. 2006;2(6 suppl 2):340
  13. Caballero-Corblan J, Eich T, Lundgren T, et al. No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation. Transplantation. 2007;84:864
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  16. Yotsumoto G, Jeschkeit-Schubbert S, Funcke C, et al. Total recovery of heart grafts of non-heart-beating donors after 3 hours of hypothermic coronary oxygen persufflation preservation in an orthotopic pig transplantation model. Transplantation. 2003;75:750
  17. Tolba RH, Schildberg FA, Schnurr C, et al. Reduced liver apoptosis after venous systemic oxygen persufflation in non-heart-beating donors. J Invest Surg. 2006;19:219
  18. Saad S, Minor T, Kötting M, et al. Extension of ischemic tolerance of porcine livers by cold preservation including postconditioning with gaseous oxygen. Transplantation. 2001;71:498
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  20. Rolles K, Foreman J, Pegg DE. A pilot clinical study of retrograde oxygen persufflation in renal preservation. Transplantation. 1989;48:339
  21. Rolles K, Foreman J, Pegg DE. Preservation of ischemically injured canine kidneys by retrograde oxygen persufflation. Transplantation. 1984;38:102
  22. Treckman JW, Paul A, Saad S, et al. Primary organ function of warm ischaemically damaged porcine kidneys after retrograde oxygen persufflation. Nephrol Dial Transplant. 2006;21:1803
  23. Minor T, Klauke H, Isselhard W. Improved preservation of the small bowel by luminal gas oxygenation: energetic status during ischemia and functional integrity upon reperfusion. Transplant Proc. 1997;29:2994
  24. Scott WE, Matsumoto S, Tanaka T, et al. Real-time noninvasive assessment of pancreatic ATP levels during cold preservation. Transplant Proc. 2008;40:403
  25. Arias-Mendoza F, Brown TR. In vivo measurement of phosphorous markers of disease. Dis Markers. 2003–2004;19:49
  26. Dobbins RL, Malloy CR. Measuring in-vivo metabolism using nuclear magnetic resonance. Curr Opin Clin Nutr Metab Care. 2003;6:501
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  29. Davidson BR, Barnard ML, Changani KK, Taylor-Robinson SD. Liver transplantation: current and potential applications of magnetic resonance spectroscopy. Liver Transpl Surg. 1997;3:481
  30. Khan SA, Cox IJ, Hamilton G, et al. In vivo and in vitro nuclear magnetic resonance spectroscopy as a tool for investigating hepatobiliary disease: a review of H and P MRS applications. Liver Int. 2005;25:273
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  32. Yoshikawa T, Suzuki Y, Kanashiro M, et al. Objective and rapid assessment of pancreas graft viability using 31P-nuclear magnetic resonance spectroscopy combined with two-layer cold storage method. Transplantation. 2004;78:78
  33. Siech M, Sotak CH, Letko G, Davis MA. A method for in vivo assessment of reversible rat pancreatic ischemia using 31P NMR spectroscopy at 2 Tesla. Magn Reson Imaging. 1995;13:463
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  35. Kuroda Y, Kawamura T, Suzuki Y, et al. A new, simple method for cold storage of the pancreas using perfluorochemical. Transplantation. 1988;46:457

 Supported by a grant from the National Center for Research Resources (U42 RR016598), National Institutes of Health (NIH), NIH National Institute of Diabetes and Digestive and Kidney Diseases (R43 DK070400), the Schott Foundation, and the Carol Olson Memorial Diabetes Research Fund.

PII: S0041-1345(10)00756-6

doi: 10.1016/j.transproceed.2010.05.091

Transplantation Proceedings
Volume 42, Issue 6 , Pages 2011-2015 , July 2010

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