Transplantation Proceedings
Volume 42, Issue 6 , Pages 2003-2005 , July 2010

Anti-CD25 Antibody (Daclizumab) Maintenance Therapy in Pancreas Transplantation

  • V.A. Kirchner

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • T.M. Suszynski

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • D.M. Radosevich

      Affiliations

    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • A. Humar

      Affiliations

    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • T.B. Dunn

      Affiliations

    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • M.J. Hill

      Affiliations

    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • E.B. Finger

      Affiliations

    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • D.E.R. Sutherland

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • R. Kandaswamy

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • Corresponding Author InformationAddress reprint requests to Dr. R. Kandaswamy, MD, Department of Surgery, 420 Delaware St SE, MMC 195 (8195), University of Minnesota, Minneapolis, MN 55455

References 

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  2. Baczkowska T, Durlik M. Calcineurin inhibitor sparing immunosuppressive regimens in kidney allograft recipients. Pol Arch Med Wewn. 2009;119:318
  3. Flechner S, Kobashigawa J, Klintmalm G. Calcineurin inhibitor–sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity. Clin Transplant. 2008;22:1–15
  4. Kaczmarek I, Schmauss D, Sodian R, et al. Late-onset tacrolimus-associated cerebellar atrophy in a heart transplant recipient. J Heart Lung Transplant. 2007;26:89
  5. Ojo A, Held P, Port F, et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med. 2003;349:931
  6. Ekberg H, Tedesco-Silva H, Demirbas A, et al. SYMPHONY: comparing standard immunosuppression to low-dose cyclosporine, tacrolimus, or sirolimus in combination with MMF, daclizumab and corticosteroids in renal transplantation. Am J Transplant. 2006;6(suppl 2):83
  7. Sageshima J, Ciancio G, Chen L, et al. Anti–interleukin-2 receptor antibodies—basiliximab and daclizumab—for the prevention of acute rejection in renal transplantation. Biologics. 2009;3:319
  8. Bruce D, Sollinger H, Humar A, et al. Multicenter survey of daclizumab induction in simultaneous kidney-pancreas transplant recipients. Transplantation. 2001;72:1637
  9. Vincenti F, Kirkman R, Light S, et al. Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. N Engl J Med. 1998;338:161
  10. Webster A, Playford E, Higgins G, et al. Interleukin-2 receptor antagonists for renal transplant recipients: a meta-analysis of randomized trials. Transplantation. 2004;77:166
  11. Post M, Raszeja-Wyszomirska J, Jarosz K, et al. Immunosuppression with low-dose daclizumab in liver transplant recipients with impaired kidney function: a single-center experience. Transplant Proc. 2009;3107
  12. Chaudhuri A, Salvatierra O, Sarwal M, et al. Extended daclizumab monotherapy for rejection-free survival in non-adherent adolescent recipients of renal allograft. Pediatr Transplant. 2009;13:927
  13. Sundberg A, Rohr M, Hartmann E, et al. Conversion to sirolimus-based maintenance immunosuppression using daclizumab bridge therapy in renal transplant recipients. Clin Transplant. 2004;18(suppl 12):61
  14. Kaplan B, West P, Neeley H, et al. Case report: use of low dose tacrolimus, mycophenolate mofetil and maintenance IL-2 receptor blockade in an islet transplant recipient. Clin Transplant. 2008;22:250
  15. Sarwal M, Vidhun J, Alexander S, et al. Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation. Transplantation. 2003;76:1331
  16. Nashan B, Light S, Hardie I, et al. Reduction of acute renal allograft rejection by daclizumab. Transplantation. 1999;67:110
  17. Tesi R, Henry M, Elkammas E, et al. Predictors of long-term primary cadaveric renal transplant survival. Clin Transplant. 1993;7:345
  18. Matas A. “Chronic rejection in renal transplant recipients: risk factors and correlates. Clin Transplant. 1994;8:332
  19. Filler G, Neuschulz I, Vollmer I, et al. Tacrolimus reversibly reduces insulin secretion in paediatric renal transplant recipients. Nephrol Dial Transplant. 2000;15:867
  20. Tamura K, Fujimura T, Tsutsumi T, et al. Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell. Transplantation. 1995;59:1606
  21. Hirano Y, Fujihura S, Ohara K, et al. Mechanism of FK506-induced glucose intolerance in rats. J Toxicol Sci. 1994;19:61
  22. Neto A, Haapalainen E, Ferreira R, et al. Metabolic and ultrastructural effects of cyclosporin A on pancreatic islets. Transplant Int. 1999;12:208
  23. Uchizono Y, Iwase M, Nakamura U, et al. Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling. Endocrinology. 2004;145:2264
  24. Larsen J, Bennett R, Burkman T, et al. Tacrolimus and sirolimus cause insulin resistance in normal Sprague Dawley rats. Transplantation. 2006;82:466
  25. Hojo M, Morimoto T, Maluccio M, et al. Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature. 1999;397:530

PII: S0041-1345(10)00748-7

doi: 10.1016/j.transproceed.2010.05.083

Transplantation Proceedings
Volume 42, Issue 6 , Pages 2003-2005 , July 2010

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