Transplantation Proceedings
Volume 42, Issue 6 , Pages 2020-2023 , July 2010

Continuous Real-time Viability Assessment of Kidneys Based on Oxygen Consumption

  • B.P. Weegman

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • ,
  • V.A. Kirchner

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • ,
  • W.E. Scott III

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • ,
  • E.S. Avgoustiniatos

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • ,
  • T.M. Suszynski

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • ,
  • J. Ferrer-Fabrega

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • ,
  • M.D. Rizzari

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • University of Texas Southwestern Medical Center Department of Surgery, Dallas, Texas
    • ,
  • L.S. Kidder

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • ,
  • R. Kandaswamy

      Affiliations

    • Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • D.E.R. Sutherland

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • ,
  • K.K. Papas

      Affiliations

    • Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota
    • Corresponding Author InformationAddress reprint requests to K.K. Papas, PhD, Schulze Diabetes Institute, Department of Surgery, University of Minnesota, 424 Harvard St. SE, Rm. 421 Minneapolis, MN 55455

References 

  1. Knoll G. Trends in kidney transplantation over the past decade. Drugs. 2008;68(Suppl 1):3–10
  2. Reznik ON, Bagnenko SF, Loginov IV, et al. Machine perfusion as a tool to select kidneys recovered from uncontrolled donors after cardiac death. Transplant Proc. 2008;40:1023
  3. Snoeijs MGJ, Buurman WA, Christiaans MHL, et al. Histological assessment of preimplantation biopsies may improve selection of kidneys from old donors after cardiac death. Am J Transplant. 2008;8:1844
  4. Papas KK, Hering BJ, Guenther L, et al. Pancreas oxygenation is limited during preservation with the two-layer method. Transplant Proc. 2005;37:3501
  5. Stowe DF, Camara AK, Heisner JS, et al. Low-flow perfusion of guinea pig isolated hearts with 26°C air-saturated Lifor solution for 20 hours preserves function and metabolism. J Heart Lung Transplant. 2008;27:1008
  6. Dutkowski P, Furrer K, Tian Y, et al. Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. Ann Surg. 2006;244:968
  7. Levy MN. Oxygen consumption and blood flow in the hypothermic, perfused kidney. Am J Physiol. 1959;197:1111
  8. Stubenitsky BM, Booster MM, Brasile L, et al. Ex vivo viability testing of kidneys after postmortem warm ischemia. ASAIO J. 2000;46:62
  9. Crane NJ, Pinto PA, Hale D, et al. Non-invasive monitoring of tissue oxygenation during laparoscopic donor nephrectomy. BMC Surg. 2008;8:8
  10. Papas KK, Pisania A, Wu H, et al. A stirred microchamber for oxygen consumption rate measurements with pancreatic islets. Biotechnol Bioeng. 2007;98:1071
  11. Papas KK, Colton CK, Nelson RA, et al. Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice. Am J Transplant. 2007;7:707
  12. Papas KK, Suszynski TM, Colton CK. Islet assessment for transplantation. Curr Opin Org Transplant. 2009;14:674
  13. Taylor MJ, Baicu SC: Current state of hypothermic machine perfusion preservation of organs: The clnical perspective. Cryobiology. Published online Oct 24, 2009
  14. Kim J, Seok YM, Jung KJ, et al. Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice. Am J Physiol Renal Physiol. 2009;297:F461
  15. Treckmann J, Nagelschmidt M, Minor T, et al. Function and quality of kidneys after cold storage, machine perfusion, or retrograde oxygen prsufflation: results from a porcine autotransplantation model. Cryobiology. 2009;59:19

 Supported by grants from the National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases (R43 DK070400), the Schott Foundation, the Carol Olson Memorial Diabetes Research Fund, the United Metal Traders, the Eunice L. Dwan Trust, the Iacocca Family Foundation, and Tom and Meredith Olson.

PII: S0041-1345(10)00747-5

doi: 10.1016/j.transproceed.2010.05.082

Transplantation Proceedings
Volume 42, Issue 6 , Pages 2020-2023 , July 2010

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