Transplantation Proceedings
Volume 42, Issue 1 , Pages 47-53 , January 2010

International Grading Scheme for Acute Cellular Rejection in Small-Bowel Transplantation: Single-Center Experience

  • P. Ruiz

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida
    • Department of Pathology, University of Miami School of Medicine, Miami, Florida
    • Corresponding Author InformationAddress reprint requests to Philip Ruiz, MD, PhD, Department of Surgery, University of Miami School of Medicine, Rosensteil Medical Sciences Building, Transplant Laboratories, 1600 NW 10th Ave, Suite 8150, Miami, FL 33136
    • ,
  • H. Takahashi

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida
    • ,
  • V. Delacruz

      Affiliations

    • Department of Pathology, University of Miami School of Medicine, Miami, Florida
    • ,
  • E. Island

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida
    • ,
  • G. Selvaggi

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida
    • ,
  • S. Nishida

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida
    • ,
  • J. Moon

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida
    • ,
  • L. Smith

      Affiliations

    • Department of Pediatrics, University of Miami School of Medicine, Miami, Florida
    • ,
  • T. Asaoka

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida
    • ,
  • D. Levi

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida
    • ,
  • A. Tekin

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida
    • ,
  • A.G. Tzakis

      Affiliations

    • Department of Surgery, University of Miami School of Medicine, Miami, Florida

References 

  1. Kato T, Ruiz P, Thompson JF, et al. Intestinal and multivisceral transplantation. World J Surg. 2002;26:226
  2. Kato T, Tzakis AG, Selvaggi G, et al. Intestinal and multivisceral transplantation in children. Ann Surg. 2006;243:756
  3. Tzakis AG, Kato T, Levi DM, et al. 100 Multivisceral transplants at a single center. Ann Surg. 2005;242:480
  4. Abu-Elmagd KM. Intestinal transplantation for short bowel syndrome and gastrointestinal failure: current consensus, rewarding outcomes, and practical guidelines. Gastroenterology. 2006;130:S132
  5. Gaynor JJ, Kato T, Selvaggi G, et al. The importance of analyzing graft and patient survival by cause of failure: an example using pediatric small intestine transplant data. Transplantation. 2006;81:1133
  6. Ruiz P, Kato T, Tzakis A. Current status of transplantation of the small intestine. Transplantation. 2007;83:1
  7. David AI, Selvaggi G, Ruiz P, et al. Blood citrulline level is an exclusionary marker for significant acute rejection after intestinal transplantation. Transplantation. 2007;84:1077
  8. Wu T, Abu-Elmagd K, Bond G, et al. A schema for histologic grading of small intestine allograft acute rejection. Transplantation. 2003;75:1241
  9. Ruiz P, Bagni A, Brown R, et al. Histological criteria for the identification of acute cellular rejection in human small bowel allografts: results of the pathology workshop at the VIII International Small Bowel Transplant Symposium. Transplant Proc. 2004;36:335
  10. Ruiz P, Weppler D, Nishida S, et al. International grading scheme for acute rejection in small bowel transplantation: implementation and experience at the University of Miami. Transplant Proc. 2006;38:1683
  11. Selvaggi G, Gaynor JJ, Moon J, et al. Analysis of acute cellular rejection episodes in recipients of primary intestinal transplantation: a single center, 11-year experience. Am J Transplant. 2007;7:1249
  12. Takahashi H, Kato T, Selvaggi G, et al. Subclinical rejection in the initial postoperative period in small intestinal transplantation: a negative influence on graft survival. Transplantation. 2007;84:689
  13. Ruiz P, Soares MF, Garcia M, et al. Lymphoplasmacytic hyperplasia (possibly pre-PTLD) has varied expression and appearance in intestinal transplant recipients receiving Campath immunosuppression. Transplant Proc. 2004;36:386
  14. Mengel M, Chapman JR, Cosio FG, et al. Protocol biopsies in renal transplantation: insights into patient management and pathogenesis. Am J Transplant. 2007;7:512
  15. Stoica SC, Cafferty F, Pauriah M, et al. The cumulative effect of acute rejection on development of cardiac allograft vasculopathy. J Heart Lung Transplant. 2006;25:420
  16. Nankivell BJ, Chapman JR. The significance of subclinical rejection and the value of protocol biopsies. Am J Transplant. 2006;6:2006
  17. Bartlett AS, Ramadas R, Furness S, et al. The natural history of acute histologic rejection without biochemical graft dysfunction in orthotopic liver transplantation: a systematic review. Liver Transplant. 2002;8:1147
  18. Solez K, Colvin RB, Racusen LC, et al. Banff '05 meeting report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy (CAN). Am J Transplant. 2007;7:518
  19. Terasaki PI, Cai J. Humoral theory of transplantation: further evidence. Curr Opin Immunol. 2005;17:541
  20. Wu T, Abu-Elmagd K, Bond G, et al. A clinicopathologic study of isolated intestinal allografts with preformed IgG lymphocytotoxic antibodies. Hum Pathol. 2004;35:1332
  21. Ruiz P, Garcia M, Pappas P, et al. Mucosal vascular alterations in isolated small-bowel allografts: relationship to humoral sensitization. Am J Transplant. 2003;3:43
  22. Ruiz P, Garcia M, Pappas P, et al. Mucosal vascular alterations in the early posttransplant period of small bowel allograft recipients may reflect humoral-based allograft rejection. Transplant Proc. 2002;34:869
  23. Troxell ML, Higgins JP, Kambham N. Evaluation of C4d staining in liver and small intestine allografts. Arch Pathol Lab Med. 2006;130:1489
  24. Everly MJ, Bloom RD, Tsai DE, et al. Posttransplant lymphoproliferative disorder. Ann Pharmacother. 2007;41:1850
  25. Ruiz P, Perez MT, Garcia M, et al. Semiquantitative measurement of mucosal fibrosis as a means of assessing chronic injury in bowel allografts. Transplant Proc. 2002;34:874
  26. Lee RG, Nakamura K, Tsamandas AC, et al. Pathology of human intestinal transplantation. Gastroenterology. 1996;110:1820
  27. Parizhskaya M, Redondo C, Demetris A, et al. Chronic rejection of small bowel grafts: pediatric and adult study of risk factors and morphologic progression. Pediatr Dev Pathol. 2003;6:240
  28. Yantiss RK, Odze RD. Pitfalls in the interpretation of nonneoplastic mucosal biopsies in inflammatory bowel disease. Am J Gastroenterol. 2007;102:890

PII: S0041-1345(09)01782-5

doi: 10.1016/j.transproceed.2009.12.026

Transplantation Proceedings
Volume 42, Issue 1 , Pages 47-53 , January 2010

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