Transplantation Proceedings
Volume 42, Issue 1 , Pages 9-14 , January 2010

Chronic Intestinal Pseudo-Obstruction Related to Viral Infections

  • R. De Giorgio

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • Corresponding Author InformationAddress reprint requests to Roberto De Giorgio, MD, PhD, Department of Clinical Medicine, Building 5, St. Orsola-Malpighi Hospital, Via Massarenti, 9, 40138 – Bologna, Italy
    • ,
  • L. Ricciardiello

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • V. Naponelli

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • M. Selgrad

      Affiliations

    • Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany
    • ,
  • G. Piazzi

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • C. Felicani

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • M. Serra

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • L. Fronzoni

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • A. Antonucci

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • R.F. Cogliandro

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • G. Barbara

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • R. Corinaldesi

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy
    • ,
  • M. Tonini

      Affiliations

    • Department of Legal Medicine, Forensic Sciences and Pharmaco-Toxicology, University of Pavia, Pavia, Italy
    • ,
  • C.H. Knowles

      Affiliations

    • Neurogastroenterology Group, Centre for Digestive Diseases, Institute of Cellular and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    • ,
  • V. Stanghellini

      Affiliations

    • Department of Clinical Medicine, University of Bologna, Bologna, Italy

References 

  1. Wood JD. Neural and humoral regulation of gastrointestinal motility. In:  Schuster MM,  Crowell MD,  Koch KL editor. Gastrointestinal Motility in Health and Disease. London: Decker; 2002;p. 19
  2. De Giorgio R, Sarnelli G, Corinaldesi R, et al. Advances in our understanding of the pathology of chronic intestinal pseudo-obstruction. Gut. 2004;53:1549
  3. Knowles CH, De Giorgio R, Kapur RP, et al. Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropathol. 2009;118:271
  4. Stanghellini V, Cogliandro RF, De Giorgio R, et al. Chronic intestinal pseudo-obstruction: manifestations, natural history and management. Neurogastroenterol Motil. 2007;19:440
  5. Antonucci A, Fronzoni L, Cogliandro L, et al. Chronic intestinal pseudo-obstruction. World J Gastroenterol. 2008;14:2953
  6. Di Nardo G, Blandizzi C, Volta U, et al. Review article: molecular, pathological and therapeutic features of human enteric neuropathies. Aliment Pharmacol Ther. 2008;28:25
  7. Soares MB, dos Santos RR. Current status and perspectives of cell therapy in Chagas disease. Mem Inst Oswaldo Cruz. 2009;104(suppl 1):325
  8. Wagner EK, Hewlett MJ. Basic Virology. In: 2nd Ed.. Malden, Mass: Blackwell; 2004;p. 311
  9. Mettenleiter TC. Pathogenesis of neurotropic herpesviruses: role of viral glycoproteins in neuroinvasion and transneuronal spread. Virus Res. 2003;92:197
  10. Steiner I, Kennedy PGE, Pachner AR. The neurotropic herpes viruses: herpes simplex and varicella-zoster. Lancet Neurol. 2007;6:1015
  11. Bollag B, Chuke WF, Frisque RJ. Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation. J Virol. 1989;63:863
  12. Dyson N, Bernards R, Friend SH, et al. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol. 1990;64:1353
  13. Krynska B, Gordon J, Otte J, et al. Role of cell cycle regulators in tumor formation in transgenic mice expressing the human neurotropic virus, JCV, early protein. J Cell Biochem. 1997;67:223
  14. Staib C, Pesch J, Gerwig R, et al. p53 inhibits JC virus DNA replication in vivo and interacts with JC virus large T-antigen. Virology. 1996;219:237
  15. Padgett BL, Walker DL, ZuRhein GM, et al. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet. 1971;1:1257
  16. Major EO, Miller AE, Mourrain P, et al. Establishment of a line of human fetal glial cells that supports JC virus multiplication. Proc Natl Acad Sci U S A. 1985;82:1257
  17. Pho MT, Ashok A, Atwood WJ. JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis. J Virol. 2000;74:2288
  18. Elphick GF, Querbes W, Jordan JA, et al. The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science. 2004;306:1380
  19. Kmieciak D, Debicki S, Trzeciak WH. Occurrence rate and genotype distribution of the JC virus (JCV) in a sample from the Polish population. J Med Virol. 2008;80:1079
  20. Monaco MC, Jensen PN, Hou J, et al. Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection. J Virol. 1998;72:9918
  21. Tornatore C, Berger JR, Houff SA, et al. Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathy. Ann Neurol. 1992;31:454
  22. Ricciardiello L, Laghi L, Ramamirtham P, et al. JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract. Gastroenterology. 2000;119:1228
  23. Vanchiere JA, Abudayyeh S, Copeland CM, et al. Polyomavirus shedding in the stool of healthy adults. J Clin Microbiol. 2009;47:2388
  24. Rencic A, Gordon J, Otte J, et al. Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma. Proc Natl Acad Sci U S A. 1996;93:7352
  25. Krynska B, Del Valle L, Croul S, et al. Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas. Proc Natl Acad Sci U S A. 1999;96:11519
  26. Del Valle L, Baehring J, Lorenzana C, et al. Expression of a human polyomavirus oncoprotein and tumour suppressor proteins in medulloblastomas. Mol Pathol. 2001;54:331
  27. Laghi L, Randolph AE, Chauhan DP, et al. JC virus DNA is present in the mucosa of the human colon and in colorectal cancers. Proc Natl Acad Sci U S A. 1999;96:7484
  28. Ricciardiello L, Chang DK, Laghi L, et al. Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissues. J Virol. 2001;75:1996
  29. Enam S, Del Valle L, Lara C, et al. Association of human polyomavirus JCV with colon cancer: evidence for interaction of viral T-antigen and beta-catenin. Cancer Res. 2002;62:7093
  30. Selgrad M, Koornstra JJ, Fini L, et al. JC virus infection in colorectal neoplasia that develops after liver transplantation. Clin Cancer Res. 2008;14:6717
  31. Shin SK, Li MS, Fuerst F, et al. Oncogenic T-antigen of JC virus is present frequently in human gastric cancers. Cancer. 2006;107:481
  32. Ricciardiello L, Baglioni M, Giovannini C, et al. Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Cancer Res. 2003;63:7256
  33. Sonsino E, Mouy R, Foucaud P, et al. Intestinal pseudoobstruction related to cytomegalovirus infection of myenteric plexus. N Engl J Med. 1984;311:196
  34. Dèchelotte PJ, Mulliez NM, Bouvier RJ, et al. Pseudo-meconium ileus due to cytomegalovirus infection: a report of three cases. Pediatr Pathol. 1992;12:73
  35. Ategbo S, Turck D, Gottrand F, et al. Chronic intestinal pseudo-obstruction associated with cytomegalovirus infection in an infant. J Pediatr Gastroenterol Nutr. 1996;23:457
  36. Besnard M, Faure C, Fromont-Hankard G, et al. Intestinal pseudo-obstruction and acute pandysautonomia associated with Epstein-Barr virus infection. Am J Gastroenterol. 2000;95:280
  37. Chang AE, Young NA, Reddick RL, et al. Small bowel obstruction as a complication of disseminated varicella-zoster infection. Surgery. 1978;83:371
  38. Vassallo M, Camilleri M, Caron BL, et al. Gastrointestinal motor dysfunction in acquired selective cholinergic dysautonomia associated with infectious mononucleosis. Gastroenterology. 1991;100:252
  39. Debinsky HS, Kamm MA, Talbot IC, et al. DNA viruses in the pathogenesis of sporadic chronic idiopathic intestinal pseudo-obstruction. Gut. 1997;41:100
  40. Selgrad M, De Giorgio R, Fini L, et al. JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction. Gut. 2009;58:25

 This work was supported by grants from the Italian Ministry of University and Research (PRIN 2007) to R. De G., G.B., and M.T.; by funds from the University of Bologna to R. De G., G.B., R.C., V.S. and University of Pavia to M.T. R. De G. is a recipient of grants from “Fondazione Del Monte di Bologna e Ravenna” and “Fondazione Cassa di Risparmio di Bologna,” Bologna, Italy.

PII: S0041-1345(09)01770-9

doi: 10.1016/j.transproceed.2009.12.014

Transplantation Proceedings
Volume 42, Issue 1 , Pages 9-14 , January 2010

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