Transplantation Proceedings
Volume 41, Issue 9 , Pages 3590-3596 , November 2009

Pretreatment With the Tumor Nerosis Factor-α Blocker Etanercept Attenuated Ischemia-Reperfusion Renal Injury

  • D.E. Choi

      Affiliations

    • Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea
    • ,
  • J.Y. Jeong

      Affiliations

    • Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea
    • ,
  • B.J. Lim

      Affiliations

    • Department of Pathology, Chungnam National University Hospital, Daejeon, Republic of Korea
    • ,
  • K.R. Na

      Affiliations

    • Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea
    • ,
  • Y.T. Shin

      Affiliations

    • Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea
    • ,
  • K.W. Lee

      Affiliations

    • Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea
    • Corresponding Author InformationAddress reprint requests to Kang Wook Lee, MD, PhD, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea

References 

  1. Fuller TF, Serkova N, Niemann CU, et al. Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts. J Urol. 2004;171:1296
  2. Da Silva M, Petruzzo P, Virieux S, et al. A primate model of renal ischemia-reperfusion injury for preclinical evaluation of the antileukocyte function associated antigen 1 monoclonal antibody odulimonab. J Urol. 2001;166:1915
  3. Troppmann C, Gillingham KJ, Benedetti E, et al. Delayed graft function, acute rejection, and outcome after cadaver renal transplantation (The multivariate analysis). Transplantation. 1995;59:962
  4. Lopez-Marti J, Sola A, Pi F, et al. Nucleotides modulate renal ischaemia-reperfusion injury by different effects on nitric oxide and superoxide. Clin Exp Pharmacol Physiol. 2003;30:242
  5. Kelly KJ, Williams WW, Colvin RB, et al. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest. 1996;97:1056
  6. Lieberthal W, Koh JS, Levine JS. Necrosis and apoptosis in acute renal failure. Semin Nephrol. 1998;18:505
  7. Azuma H, Nadeau K, Takada M, et al. Cellular and molecular predictors of chronic renal dysfunction after initial ischemia/reperfusion injury of a single kidney. Transplantation. 1997;64:190
  8. Harper N, Hughes M, MacFarlane M, et al. Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. J Biol Chem. 2003;278:25534
  9. Donnahoo KK, Meng X, Ayala A, et al. Early kidney TNF-alpha expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. Am J Physiol. 1999;277:R922
  10. Mohler KM, Torrance DS, Smith CA, et al. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J Immunol. 1993;151:1548
  11. Scallon B, Cai A, Solowski N, et al. Binding and functional comparisons of two types of tumor necrosis factor antagonists. J Pharmacol Exp Ther. 2002;301:418
  12. Rabb H, O'Meara YM, Maderna P, et al. Leukocytes, cell adhesion molecules and ischemic acute renal failure. Kidney Int. 1997;51:1463
  13. Donnahoo KK, Shames BD, Harken AH, et al. Review article: the role of tumor necrosis factor in renal ischemia-reperfusion injury. J Urol. 1999;162:196
  14. Navarro JF, Mora-Fernandez C. The role of TNF-alpha in diabetic nephropathy: pathogenic and therapeutic implications. Cytokine Growth Factor Rev. 2006;17:441
  15. Liu GY, Hung YC, Hsu PC, et al. Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species. Apoptosis. 2005;10:569
  16. Leonard M, Ryan MP, Watson AJ, et al. Role of MAP kinase pathways in mediating IL-6 production in human primary mesangial and proximal tubular cells. Kidney Int. 1999;56:1366
  17. Nakamura A, Imaizumi A, Yanagawa Y, et al. Suppression of tumor necrosis factor-alpha by beta2-adrenoceptor activation: role of mitogen-activated protein kinases in renal mesangial cells. Inflamm Res. 2003;52:26
  18. Gobe G, Zhang XJ, Willgoss DA, et al. Relationship between expression of Bcl-2 genes and growth factors in ischemic acute renal failure in the rat. J Am Soc Nephrol. 2000;11:454
  19. Chien CT, Chang TC, Tsai CY, et al. Adenovirus-mediated bcl-2 gene transfer inhibits renal ischemia/reperfusion induced tubular oxidative stress and apoptosis. Am J Transplant. 2005;5:1194

PII: S0041-1345(09)01442-0

doi: 10.1016/j.transproceed.2009.05.042

Transplantation Proceedings
Volume 41, Issue 9 , Pages 3590-3596 , November 2009

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