Transplantation Proceedings
Volume 41, Issue 9 , Pages 3575-3579 , November 2009

Modified Spectrometry (O2C Device) of Intraoperative Microperfusion Predicts Organ Function After Kidney Transplantation: A Pilot Study

  • G. Fechner

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany
    • Corresponding Author InformationAddress reprint requests to Dr Guido Fechner, MD, Bonn University, Sigmund-Freud-Str 25, D-53105 Bonn, Germany
    • ,
  • J. von Pezold

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany
    • ,
  • O. Luzar

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany
    • ,
  • S. Hauser

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany
    • ,
  • R.H. Tolba

      Affiliations

    • Institute of Laboratory Animal Science, University Hospital Aachen, Aachen, Germany
    • ,
  • S.C. Müller

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany

References 

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  2. Ojo a O, Leichtman a B, Punch JD, et al. Impact of pre-existing donor hypertension and diabetes mellitus on cadaveric renal transplant outcomes. Am J Kidney Dis. 2000;36:153
  3. Port FK, Dykstra DM, Merion RM, et al. Trends and results for organ donation and transplantation in the United States, 2004. Am J Transplant. 2005;5(4 Pt 2):843
  4. Lim EC, Terasaki PI. Early graft function. Clin Transpl. 1991;6:401
  5. Woo YM, Gill JS, Johnson N, et al. The advanced age deceased kidney donor: current outcomes and future opportunities. Kidney Int. 2005;67:2407
  6. Opelz G, Dohler B. Multicenter analysis of kidney preservation. Transplantation. 2007;83:247
  7. Polyak MM, Arrington BO, Stubenbord WT, et al. The influence of pulsatile preservation on renal transplantation in the 1990s. Transplantation. 2000;69:249
  8. Ollinger R, Kogler P, Biebl M, et al. Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function. Clin Transplant. 2008;22:418
  9. Bretan PN, Lobo E, Chang JA, et al. Assessment of preservation induced reperfusion injury via intraoperative renal transplant blood flow and endothelin concentration studies. J Urol. 1997;158(3 Pt 1):714
  10. Gorbach A, Simonton D, Hale DA, et al. Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging. Am J Transplant. 2003;3:988
  11. Beckert S, Witte MB, Konigsrainer A, et al. The impact of the Micro-Lightguide O2C for the quantification of tissue ischemia in diabetic foot ulcers. Diabetes Care. 2004;27:2863
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  14. Zijlstra WG, Buursma A, Meeuwsen-Van Der Roest WP. Absorption spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin. Clin Chem. 1991;37:1633
  15. Moller KO, Nilsson G, Fagrell B. Laser-Doppler flowmetry for microcirculation monitoring. Introduction. Technol Health Care. 1999;7:i
  16. Saba H, Munusamy S, Macmillan-Crow LA. Cold preservation mediated renal injury: involvement of mitochondrial oxidative stress. Ren Fail. 2008;30:125
  17. Angelescu M, Kraus T, Wiesel M, et al. Assessment of renal graft function by perioperative monitoring of cortical microcirculation in kidney transplantation. Transplantation. 2003;75:1190
  18. Lisik W, Gontarczyk G, Kosieradzki M, et al. Intraoperative blood flow measurements in organ allografts can predict postoperative function. Transplant Proc. 2007;39:371
  19. Basile DP. The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function. Kidney Int. 2007;72:151
  20. Maathuis MH, Manekeller S, Van Der Plaats A, et al. Improved kidney graft function after preservation using a novel hypothermic machine perfusion device. Ann Surg. 2007;246:982;discussion 989
  21. Brezis M, Rosen S. Hypoxia of the renal medulla—its implications for disease. N Engl J Med. 1995;332:647

PII: S0041-1345(09)01439-0

doi: 10.1016/j.transproceed.2009.06.234

Transplantation Proceedings
Volume 41, Issue 9 , Pages 3575-3579 , November 2009

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