Transplantation Proceedings
Volume 41, Issue 9 , Pages 3575-3579, November 2009

Modified Spectrometry (O2C Device) of Intraoperative Microperfusion Predicts Organ Function After Kidney Transplantation: A Pilot Study

  • G. Fechner

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany
    • Corresponding Author InformationAddress reprint requests to Dr Guido Fechner, MD, Bonn University, Sigmund-Freud-Str 25, D-53105 Bonn, Germany
    • ,
  • J. von Pezold

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany
    • ,
  • O. Luzar

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany
    • ,
  • S. Hauser

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany
    • ,
  • R.H. Tolba

      Affiliations

    • Institute of Laboratory Animal Science, University Hospital Aachen, Aachen, Germany
    • ,
  • S.C. Müller

      Affiliations

    • Department of Urology, Bonn University, Bonn, Germany

Abstract 

Background

Delayed graft function (DGF) is defined as posttransplantation dialysis within 1 week, which might be associated with impaired long-term graft survival. The aim of our pilot study was to establish the ability of intraoperative spectrometry of allograft microperfusion to predict DGF.

Methods

Twenty human kidney allografts transplanted from deceased donors were evaluated intraoperatively after reperfusion using modified organ spectrometry (O2C device). We examined hemoglobin oxygen saturation, intravascular amount of hemoglobin, and microperfusion flow/velocity.

Results

Retrospectively, 10/20 (50%) allografts with measurable impairment of cortical hemoglobin oxygen saturation and microperfusion flow/velocity developed DGF. Retrospectively, we found that if the intravascular amount of hemoglobin was increased upon intraoperative measurement, the kidney was prone to develop DGF.

Conclusions

Spectrometry data predicted DGF. Our results supported the thesis that impaired microperfusion is the key to DGF and might be related to postcapillary endothelial damage or intravascular sludge.

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PII: S0041-1345(09)01439-0

doi:10.1016/j.transproceed.2009.06.234

Transplantation Proceedings
Volume 41, Issue 9 , Pages 3575-3579, November 2009

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