Reversal of Graft Steatosis After Liver Transplantation: Prospective Study

Li, J.; Liu, B.; Yan, L.-N.; Zuo, Y.-X.; Li, B.; Zeng, Y.; Zhang, S.F.; Li, F.-G.

doi:10.1016/j.transproceed.2009.06.222

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Volume 41, Issue 9 , Pages 3560-3563, November 2009

Reversal of Graft Steatosis After Liver Transplantation: Prospective Study

J. Li, PhD
- Department of Anesthesiology and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
B. Liu
- Division of Liver Transplantation, West China Hospital, Sichuan University, Chengdu, China
L.-N. Yan, MD, PhD
- Division of Liver Transplantation, West China Hospital, Sichuan University, Chengdu, China
- Address reprint requests to Lu-Nan Yan, MD, PhD, Division of Liver Transplantation, West China Hospital, Sichuan University, Chengdu 610041, China
Y.-X. Zuo
- Department of Anesthesiology and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
B. Li
- Division of Liver Transplantation, West China Hospital, Sichuan University, Chengdu, China
Y. Zeng
- Division of Liver Transplantation, West China Hospital, Sichuan University, Chengdu, China
S.F. Zhang
- Department of Pathology, West China Hospital, Sichuan University, Chengdu, China
F.-G. Li
- Division of Liver Transplantation, West China Hospital, Sichuan University, Chengdu, China

Abstract

Objective

To determine the risk factors for reversal of liver graft steatosis.

Patients and Methods

This prospective study included 70 patients (47 men and 23 women) who received steatotic liver grafts between July 2003 and February 2008. No grafts from prisoners were used in the study. Patients were divided into 3 groups according to degree of liver steatosis, as follows: mild (n = 29, group 1), moderate (n = 23, group 2), and severe (n = 18, group 3).

Results

The median (SD) degree of steatosis in liver grafts at transplantation was 15.7% (7.3%) in group 1, 26.3% (10.5%) in group 2, and 45.1% (8.3%) in group 3. Postoperative histologic analysis demonstrated dramatically decreased steatosis in all graft recipients.

Conclusion

Graft steatosis can be decreased substantially after liver transplantation. Factors for reversibility of steatosis include donor age, degree of macrovesicular steatosis, and cold ischemia time.