Lack of Association of Polymorphisms 239+34A/C in the SOD1 Gene and 47C/T in the SOD2 Gene With Delayed Graft Function and Acute and Chronic Rejection of Kidney Allografts

Dutkiewicz, G.; Domanski, L.; Binczak-Kuleta, A.; Pawlik, A.; Safranow, K.; Dziedziejko, V.; Wisniewska, M.; Ciechanowicz, A.; Ciechanowski, K.

doi:10.1016/j.transproceed.2009.06.221

« Previous Next »Transplantation Proceedings
Volume 41, Issue 9 , Pages 3701-3703, November 2009

Lack of Association of Polymorphisms 239+34A/C in the SOD1 Gene and 47C/T in the SOD2 Gene With Delayed Graft Function and Acute and Chronic Rejection of Kidney Allografts

G. Dutkiewicz
- Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
L. Domanski
- Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
A. Binczak-Kuleta
- Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland
A. Pawlik
- Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland
- Address reprint requests to Andrzej Pawlik, MD, PhD, Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland
K. Safranow
- Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
V. Dziedziejko
- Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
M. Wisniewska
- Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
A. Ciechanowicz
- Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland
K. Ciechanowski
- Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland

Abstract

The superoxide dismutases (SODs) seem to be the most important enzymes involved in defense against reactive oxygen species, in particular against superoxide anion radicals. We hypothesized that genetic variability of antioxidant enzymes may have a role in development of these complications. The objective of the present study was to examine the association between polymorphisms 239+34A/C in the SOD1 gene or 47C/T in the SOD2 gene and development of delayed graft function (DGF) and acute or chronic rejection. The study included 187 recipients of first renal transplants. Patient history was analyzed taking into account DGF, acute rejection episodes, and chronic rejection. The polymorphisms were analyzed using the polymerase chain reaction–restriction fragment length polymorphism method. There were no significant associations between the polymorphisms and DGF or acute or chronic rejection. Our findings suggest that polymorphisms in SOD1 and SOD2 are not associated with development of either DGF or acute or chronic rejection.