Transplantation Proceedings
Volume 41, Issue 9 , Pages 3539-3544 , November 2009

Impact of Donor Cause of Death on Transplant Outcomes: UNOS Registry Analysis

References 

  1. Anyanwu AC, Banner NR, Radley-Smith R, et al. Long-term results of cardiac transplantation from live donors: the domino heart transplant. J Heart Lung Transplant. 2002;21:971
  2. Bos EM, Leuvenink HG, van Goor H, et al. Kidney grafts from brain dead donors: inferior quality or opportunity for improvement?. Kidney Int. 2007;72:797
  3. Avlonitis VS, Wigfield CH, Golledge HD, et al. Early hemodynamic injury during donor brain death determines the severity of primary graft dysfunction after lung transplantation. Am J Transplant. 2007;7:83
  4. Braun C, Vetter S, Conzelmann T, et al. Improved recovery following posttransplant acute renal failure in rat renal isografts with an oral endothelin-A receptor antagonist. Exp Nephrol. 2000;8:283
  5. Gasser M, Waaga AM, Kist-Van Holthe JE, et al. Normalization of brain death-induced injury to rat renal allografts by recombinant soluble P-selectin glycoprotein ligand. J Am Soc Nephrol. 2002;13:1937
  6. Zhang SJ, Ma TW, Ma XX, et al. Protective effects of N-acetylcysteine on brain-dead rat liver. Hepatobiliary Pancreat Dis Int. 2006;5:428
  7. Szabo G, Buhmann V, Bahrle S, et al. Brain death impairs coronary endothelial function. Transplantation. 2002;73:1846
  8. Valantine HA. Cardiac allograft vasculopathy: central role of endothelial injury leading to transplant “atheroma.”. Transplantation. 2003;76:891
  9. Santiago-Delpin EA. The endothelium and early immune activation: new perspective and interactions. Transplant Proc. 2004;36:1709
  10. Gasser M, Waaga-Gasser AM, Grimm MW, et al. Selectin blockade plus therapy with low-dose sirolimus and cyclosporin a prevent brain death-induced renal allograft dysfunction. Am J Transplant. 2005;5(4 Pt 1):662
  11. Koo DD, Welsh KI, McLaren AJ, et al. Cadaver versus living donor kidneys: impact of donor factors on antigen induction before transplantation. Kidney Int. 1999;56:1551
  12. Takada M, Nadeau KC, Hancock WW, et al. Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation. 1998;65:1533
  13. Filipponi F, Catalano G, Oliveri F, et al. Changing typology of brain death liver donors: characteristics and impact of risk factors on short-term outcome. Hepatogastroenterology. 2002;49:1395
  14. Taylor DO, Edwards LB, Boucek MM, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult heart transplant report—2005. J Heart Lung Transplant. 2005;24:945
  15. Trulock EP, Edwards LB, Taylor DO, et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-first official adult lung and heart-lung transplant report—2004. J Heart Lung Transplant. 2004;23:804
  16. Caballero F, Lopez-Navidad A, Leal J, et al. Donor age and cause of brain death influence the number of organs retrieved and grafted. Transplant Proc. 1999;31:2589
  17. Lavrijssen AT, Peltenburg HG, Tiebosch A, et al. The relationship between cause of death of the kidney donor and the presence of ischemic lesions in the kidney. Transpl Int. 1992;5(suppl 1):S433
  18. Nyberg SL, Matas AJ, Rogers M, et al. Donor scoring system for cadaveric renal transplantation. Am J Transplant. 2001;1:162
  19. UNOS: Organ Procurement and Transplantation Network—Standard Transplant Analysis and Research database. Richmond, VA: United Network Organ Sharing; 2008;[updated 2008; cited] http://www.OPTN.org
  20. Abelson-Mitchell N. Epidemiology and prevention of head injuries: literature review. J Clin Nurs. 2008;17:46
  21. Yusuf S, Reddy S, Ounpuu S, et al. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001;104:2746
  22. Troppmann C, Almond PS, Escobar FS, et al. Donor age and cause of death affect cadaver renal allograft outcome. Transplant Proc. 1991;23(1 Pt 2):1365
  23. White HJ, Evans DB, Calne RY. Function of cadaver renal homografts in relation to age of donor, cause of death, and ischemia time. Br Med J. 1968;4:739
  24. Ojo AO, Heinrichs D, Emond JC, et al. Organ donation and utilization in the USA. Am J Transplant. 2004;4(suppl 9):27
  25. Gnant M, Wamser P, Barlan M, et al. Impact of donor cause of death on renal graft function—a multivariate analysis of 1545 kidney transplants. Transplant Proc. 1993;25:3102
  26. Gaynor JJ, Moon JI, Kato T, et al. A cause-specific hazard rate analysis of prognostic factors among 877 adults who received primary orthotopic liver transplantation. Transplantation. 2007;84:155
  27. Northup PG, Pruett TL, Kashmer DM, et al. Donor factors predicting recipient survival after liver retransplantation: the retransplant donor risk index. Am J Transplant. 2007;7:1984
  28. Powner DJ. Factors during donor care that may affect liver transplantation outcome. Prog Transplant. 2004;14:241;quiz 8
  29. Tsai FC, Marelli D, Bresson J, et al. Use of hearts transplanted from donors with atraumatic intracranial bleeds. J Heart Lung Transplant. 2002;21:623
  30. Baroldi G, Di Pasquale G, Silver MD, et al. Type and extent of myocardial injury related to brain damage and its significance in heart transplantation: a morphometric study. J Heart Lung Transplant. 1997;16:994
  31. Yamani MH, Lauer MS, Starling RC, et al. Impact of donor spontaneous intracranial hemorrhage on outcome after heart transplantation. Am J Transplant. 2004;4:257
  32. Baroldi G, Silver MD, De Maria R, et al. Frequency and extent of contraction band necrosis in orthotopically transplanted human hearts (A morphometric study). Int J Cardiol. 2003;88:267
  33. Johnston O, O'Kelly P, Spencer S, et al. The impact of donor spontaneous intracranial haemorrhage vs. other donors on long-term renal graft and patient survival. Clin Transplant. 2006;20:91
  34. Aird WC. Endothelium and allotransplantation. Transplantation. 2006;82(1 suppl):S6
  35. Valujskikh A, Heeger PS. Emerging roles of endothelial cells in transplant rejection. Curr Opin Immunol. 2003;15:493

 This work was supported in part by Health Resources and Services Administration contract 231-00-0115. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

PII: S0041-1345(09)01327-X

doi: 10.1016/j.transproceed.2009.06.192

Transplantation Proceedings
Volume 41, Issue 9 , Pages 3539-3544 , November 2009