Renal transplantationOutcomeClinical Application of Cordyceps sinensis on Immunosuppressive Therapy in Renal Transplantation
Section snippets
Materials and Methods
Among 202 patients (164 men/38 women) of overall mean age of 36.0 ± 11.1 years who underwent renal transplantations between January 2005 and December 2007, we randomly by lottery using a random table assigned subjects into a treatment (n = 93) and a control group (n = 109).
All patients were given intraoperative and postoperative pulse therapy for 5 days after transplantation with methylprednisolone (3.0 g) and cyclophosphamide (0.7 g). The immunosuppressive regimen of CsA (Neoral, Novartis),
Results
The 93 treated patients included 75 males and 18 females of ages ranging from 12 to 63 years with a course of illness ranging from 1.0 to 7.9 years. The 109 control patients included 89 males and 20 females with an age range from 16 to 65 years and a course of illness from 1.0 to 6.2 years. The groups did not differ significantly in demographic or immunological parameters (P > .05 by chi-square test and variance analysis; Table 1).
At the 1-year follow-up visit after transplantation, the patient
Discussion
CsA is one of the main immunosuppressive agents in renal transplantation, but its side effects limit its application. Long-term nephrotoxicity causes CAN, which is still a main factor shortening renal allograft survival.22 These side effects depend on the dose and concentration of CsA.23 Unfortunately, decreased CsA is associated with an increased risk for acute rejection episodes, especially at 4 to 6 months after transplantation.24 Therefore, the search for a drug that has immunosuppressive
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Effects of Acremonium terricola culture on performance, milk composition, rumen fermentation and immune functions in dairy cows
2018, Animal Feed Science and TechnologyCitation Excerpt :Cordycepin and polysaccharides in ATC are used as prebiotics in animal nutrition (Scholzahrens et al., 2007) and have great potential as replacements for antibiotics in poultry production (Han et al., 2015). Additionally, Cordyceps sinensis and bioactive substances have the effect of adjusting the levels of alanine transaminase and aspartate transaminase and contents of total cholesterol and urea nitrogen in patients and mice (Li et al., 2009; Choi et al., 2014). All these results indicate that ATC possesses great potential to modulate rumen fermentation, apparent digestibility of nutrients and blood metabolism in dairy cows.
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2017, Complementary Therapies in MedicineCitation Excerpt :The study methodology was mostly incompletely reported in the trials (Fig. 2). Two studies26,28 used a random number table to generate random allocation while the other studies did not describe the method used for randomization. None of the trials described allocation concealment, and blinding of participants, personnel or outcome assessors.
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This project was supported by grants from the Clinical Key Subjects Program of the Ministry of Public Health, National Natural Science Foundation of China (30772096), the Project of Young in the First Affiliated Hospital, Medical College, Xi'an Jiaotong University (2006YK4), and the Key Program of Science and Technology of Shaanxi Province (2007DKG-67).