Transplantation Proceedings
Volume 41, Issue 3 , Pages 820-823 , April 2009

Effects of Allopurinol on Ischemia and Reperfusion in Rabbit Livers

  • M.O. Taha

      Affiliations

    • Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • Corresponding Author InformationAddress reprint requests to Murched Omar Taha, MD, PhD, Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, Rua Botucatu, 740, CEP 04023-900, São Paulo-SP, Brazil
    • ,
  • M.J. Simões

      Affiliations

    • Department of Morphology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • E.C. Noguerol

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • F.P. Mendonça

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • H.M.A. Pascoalick

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • R.A.M. Alves

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • M.E.M. Vivian

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • F.P. Morales

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • A.C.A. Campos

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • K.G. Magalhães

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • P.S. Venerando

      Affiliations

    • Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • I.L.S. Tersariol

      Affiliations

    • University of Mogi das Cruzws, São Paulo, Brazil
    • ,
  • H.P. Monteiro

      Affiliations

    • Department of Biochemistry, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • I. Oliveira Jr

      Affiliations

    • Department of Morphology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • A. Jurkiewicz

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • A. Caricati-Neto

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil

References 

  1. Rhoden E, Pereira-Lima L, Lucas M, et al. The effects of allopurinol in hepatic ischemia and reperfusion: experimental study in rats. Eur Surg Res. 2000;32:215
  2. Yamamori T, Inanami O, Nagahata H, et al. Phosphoinositide 3- kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt. Biochem Biophys Res Commun. 2004;316:720
  3. Arteel GE. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology. 2003;124:778
  4. Czaja MJ. Induction and regulation of hepatocyte apoptosis by oxidative stress. Antioxid Redox Signal. 2002;4:759
  5. Mochida S, Arai M, Ohno A, et al. Oxidative stress in hepatocytes and stimulatory state of Kupffer cells after reperfusion differ between warm and cold ischemia in rats. Liver. 1994;14:234
  6. Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology. 2003;125:1246
  7. Dorman RB, Wunder C, Saba H, et al. NAD(P)H oxidase contributes to the progression of remote hepatic parenchymal injury and endothelial dysfunction, but not microvascular perfusion deficits. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1025
  8. Harada H, Hines IN, Flores S, et al. Role of NADPH oxidase-derived superoxide in reduced size liver ischemia and reperfusion injury. Arch Biochem Biophys. 2004;423:103
  9. Stolk J, Hiltermann TJ, Dijkman JH, et al. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am J Respir Cell Mol Biol. 1994;11:95
  10. He SQ, Zhang YH, Venugopal SK, et al. Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice. Liver Transpl. 2006;12:1869
  11. Wu J, Liu L, Yen RD, et al. Liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice. Hepatology. 2004;40:195
  12. Babior BM. NADPH oxidase: an update. Blood. 1999;93:1464
  13. Cheng G, Cao Z, Xu X, et al. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene. 2001;269:131
  14. Lentsch AB, Kato A, Yoshidome H, et al. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology. 2000;32:169
  15. Kono H, Rusyn I, Uesugi T, et al. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1005

 Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenadoria de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil.

PII: S0041-1345(09)00189-4

doi: 10.1016/j.transproceed.2009.02.051

Transplantation Proceedings
Volume 41, Issue 3 , Pages 820-823 , April 2009

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