Transplantation Proceedings
Volume 41, Issue 3 , Pages 816-819 , April 2009

l-Arginine Supplementation Protects Against Hepatic Ischemia–Reperfusion Lesions in Rabbits

  • M.O. Taha

      Affiliations

    • Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • Corresponding Author InformationAddress reprint requests to Murched Omar Taha, MD, PhD, Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, Rua Botucatu, 740, CEP 04023-900, São Paulo-SP, Brazil
    • ,
  • M.J. Simões

      Affiliations

    • Department of Morphology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • M.A. Haddad

      Affiliations

    • Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • R.C. Capelato

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • N. Budny

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • A.H. Matsumoto

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • P.C.M. Soares

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • W.M. Santos

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • G.D. Armeato

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • C.M. Araki

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • J.S.M. Gomes

      Affiliations

    • Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • K.G. Magalhães

      Affiliations

    • Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • I.L.S. Tersariol

      Affiliations

    • University of Mogi das Cruzws, São Paulo, Brazil
    • ,
  • H.P. Monteiro

      Affiliations

    • Department of Biochemistry, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • I. Oliveira Jr

      Affiliations

    • Department of Morphology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • A. Jurkiewicz

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • A. Caricati-Neto

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil

References 

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  2. Ishizaki N, Zhu Y, Zhang S, et al. Comparison of various lazaroid compounds for protection against ischemic liver injury. Transplantation. 1997;63:202
  3. Urakami A, Todo S, Zhu Y, et al. Attenuation of ischemic liver injury by monoclonal anti-endothelin antibody, AwETN40. J Am Coll Surg. 1997;185:358
  4. Ma TT, Ischiropoulos H, Brass CA. Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion. Gastroenterology. 1995;108:463
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  10. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333:664
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  12. Baek KJ, Thiel BA, Lucas S, et al. Macrophage nitric oxide synthase subunits. J Biol Chem. 1993;268:21120
  13. Nussler AK, Billiar TR. Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukoc Biol. 1993;54:171
  14. Rapoport RM, Murad F. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res. 1983;52:352
  15. Radamoski MW, Palmer RMJ. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 1987;ii:1057
  16. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA. 1991;88:4651
  17. Davenpeck KL, Gauthier TW, Lefer AM. Inhibition of endothelil-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Gastroenterology. 1994;107:1050
  18. Harbrecht BG, Wang SC, Simmons RL, et al. Cyclic GMP and guanylate cyclase mediate lipopolysaccharide-induced Kupffer cell tumor necrosis factor-a synthesis. J Leukoc Biol. 1995;57:297
  19. Kawada N, Tran-thi TA, Klein H, et al. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances (Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus). Eur J Biochem. 1993;213:815
  20. Tsao PS, Lefer AM. Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts. Am J Physiol. 1990;259:H1660
  21. Langle F, Steininger R, Waldmann E, et al. Improvement of cardiac output and liver blood flow and reduction of pulmonary vascular resistance by intravenous infusion of L-arginine during the early reperfusion period in pig liver transplantation. Transplantation. 1997;63:1225
  22. Rees D, Palmer M, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A. 1989;86:3875
  23. Girerd XJ, Hirsch AT, Cooke JP, et al. L-arginine augments endothelium- dependent vasodilation in cholesterol-fed rabbits. Circ Res. 1990;67:1301
  24. Fineman J, Chang R, Soifer S. L-arginine, a precursor of EDRF in vivo, produces pulmonary vasodilation in lambs. Am J Physiol. 1991;261:H1563
  25. Kourembanas S, McQuillan LP, Leung GK, et al. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest. 1993;92:99
  26. Hotter G, Closa D, Pi F, et al. Nitric oxide and arachidonate metabolism in ischemia-reperfusion associated with pancreas transplantation. Transplantation. 1995;59:417
  27. Lefer DJ, Nakanishi K, Johnston WE, et al. Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs. Circulation. 1993;88:2337
  28. Beckman JS, Beckman TW, Chen J, et al. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A. 1990;87:1620

 Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenadoria de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil.

PII: S0041-1345(09)00188-2

doi: 10.1016/j.transproceed.2009.02.050

Transplantation Proceedings
Volume 41, Issue 3 , Pages 816-819 , April 2009

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