Transplantation Proceedings
Volume 41, Issue 3 , Pages 812-815 , April 2009

Protective Effects of Heparin on Hepatic Ischemia and Reperfusion Lesions in Rabbits

  • M.O. Taha

      Affiliations

    • Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • Corresponding Author InformationAddress reprint requests to Murched Omar Taha, MD, PhD, Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, Rua Botucatu, 740, CEP 04023-900, São Paulo-SP, Brazil
    • ,
  • P.F.Z.R.A. Gonçalves

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • R.O.G. Vidigal

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • G.P.S. Sacchi

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • F.G. Pinheiro

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • L.S.G. Brandão

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • S. Feguri

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • A.M. Moraes-Filho

      Affiliations

    • Department of Medicine, Federal University of Grande Dourados (UFGD), Grande-Dourados-MS, Brazil
    • ,
  • M.M. Ghadie

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • K.G. Magalhães

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • M.J. Simões

      Affiliations

    • Department of Morphology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • I.L.S. Tersariol

      Affiliations

    • University of Mogi das Cruzws, São Paulo, Brazil
    • ,
  • H.P. Monteiro

      Affiliations

    • Department of Biochemistry, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • I. Oliveira Jr

      Affiliations

    • Department of Morphology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • A. Jurkiewicz

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • A. Caricati-Neto

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil

References 

  1. Zhang YY, Wang XY, Wang XR, et al. Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury. J Ethnopharmacol. 2006;108:355
  2. Culmsee C, Krieglstein J. Emerging pharmacotherapeutic strategies for the treatment of ischemic stroke. Drug Discov Today Ther Strat. 2006;3:621
  3. Longa EZ, Weinstain PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84
  4. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985;260:3440
  5. Love S. Oxidative stress in brain ischemia. Brain Pathol. 1999;9:119
  6. White BC, Sullivan JM, DeGracia DJ, et al. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci. 2000;179:1
  7. Margaill I, Plotkine M, Lerouet D. Antioxidant strategies in the treatment of stroke. Free Radic Biol Med. 2005;39:429
  8. Fuh KC, Meneshian A, Patel CB, et al. Signal transduction by reactive oxygen species: alternative paradigms for signaling specificity. Surgery. 2002;131:601
  9. Durukan A, Tatlisumak T. Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behav. 2007;87:179
  10. Samama MM, Desnoyers PC, Conard J, et al. Acute ischemic stroke and heparin treatments. Thromb Haemost. 1997;78:173
  11. Kay R, Wong KS, Yu YL, et al. Low-molecular-weight heparin for the treatment of acute ischemic stroke. N Engl J Med. 1995;333:1588
  12. The FISS bis Investigators Group. Fraxiparine in ischemic Stroke Study (FISS bis). Cerebrovasc Dis. 1998;8(4):19
  13. He SQ, Zhang YH, Venugopal SK, et al. Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice. Liver Transpl. 2006;12:1869
  14. The Publications Committee for the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators. Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischemic stroke: a randomized controlled trial. JAMA. 1998;279:1265
  15. Berge E, Sandset PM. Heparin in Acute Embolic Stroke Trial (HAEST). Cerebrovasc Dis. 1999;S1:127
  16. Diener HC, Ringelstein EB, von Kummer R, et al. Treatment of acute ischemic stroke with the low-molecular-weight heparin certoparin: results of the TOPAS trial. Stroke. 2001;32:22
  17. Bath PM, Lindenstrom E, Boysen G. Tinzaparin in acute ischaemic stroke (TAIST): a randomised aspirin-controlled trial. Lancet. 2001;358:702

 Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenadoria de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil.

PII: S0041-1345(09)00180-8

doi: 10.1016/j.transproceed.2009.02.042

Transplantation Proceedings
Volume 41, Issue 3 , Pages 812-815 , April 2009

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