Transplantation Proceedings
Volume 41, Issue 3 , Pages 807-811 , April 2009

Role of Purines on Hepatic Ischemia–Reperfusion Lesions in Rabbit

  • M.O. Taha

      Affiliations

    • Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • Corresponding Author InformationAddress reprint request to Murched Omar Taha, MD/PhD, Professor of Department of Surgery – Federal University of São Paulo – Escola Paulista de Medicina, Rua Botucatu, 740, CEP 04023-900, São Paulo-SP, Brazil
    • ,
  • M.J. Simões

      Affiliations

    • Department of Morphology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • M.V. Mendonça

      Affiliations

    • Medicine School of Federal University of Grande Dourados (UFGD), Grande Dourados–MS, Brazil
    • ,
  • F.R.C. Lugo

      Affiliations

    • Medicine School of Federal University of Grande Dourados (UFGD), Grande Dourados–MS, Brazil
    • ,
  • R. Carmo-Filho

      Affiliations

    • Medicine School of Federal University of Grande Dourados (UFGD), Grande Dourados–MS, Brazil
    • ,
  • J.L. Lazarini Junior

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • M.Z. Bessa

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • T.D. Marconi

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • K.G. Magalhães

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • J.H. Soares

      Affiliations

    • Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • I.L.S. Tersariol

      Affiliations

    • University of Mogi das Cruzes, São Paulo, Brazil
    • ,
  • H.P. Monteiro

      Affiliations

    • Department of Biochemistry, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • I. Oliveira Jr

      Affiliations

    • Department of Morphology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • A. Jurkiewicz

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil
    • ,
  • A. Caricati-Neto

      Affiliations

    • Department of Pharmacology, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil

References 

  1. Baue AE, Chaudry IH, Wurth MA, et al. Cellular alterations with shock and ischemia. Angiology. 1974;25:31
  2. Trump BF, Mergner WJ, Kaiing NY, et al. Studies on the subcellular pathophysiology of ischemia. Circulation. 1976;53(suppl 1):1
  3. Mittnacht S, Sherman SC, Farber JL. Reversal of ischemic mitochondrial dysfunction. J Biol Chem. 1979;254:9871
  4. Marubayashi S, Takenaka M, Dohi K, et al. Adenine nucleotide metabolism during hepatic ischemia and subsequent blood flow periods and its relation to organ viability. Transplantation. 1980;30:294
  5. Warnick CT, Lazarus HM. Recovery of nucleotide levels after cell injury. Can J Biochem. 1981;59:116
  6. Hirasawa H, Chaudry IH, Baue AE. Improved hepatic function and survival with adenosine triphosphate–magnesium chloride after hepatic ischemia. Surgery. 1978;88:655
  7. He SQ, Zhang YH, Venugopal SK, et al. Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice. Liver Transpl. 2006;12:1869
  8. Wu J, Liu L, Yen RD, et al. Liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice. Hepatology. 2004;40:195
  9. Wang WY, Taki Y, Morimoto T, et al. Effects of partial ischemia and reflow on mitochondrial metabolism in rat liver. Eur J Surg Res. 1988;20:181
  10. Frederiks WM, Marx F. Changes in cytoplasmic and mitochondrial enzymes in rat liver after ischemia followed by reperfusion. Exp Mol Pathol. 1987;47:291
  11. Lohse W, Otto T, Pahlig H, et al. Prognostic value of glutamyl dehydrogenase activity in clinical liver transplantation. Transplantation. 1984;38:559
  12. Ernster L, Kaylenstierna B: In: Racker E, (ed): Membrane of mitochondria and chloroplasts. New York: Van Nostrand-Reinhold; 172
  13. Taki Y, Gubernatis G, Yamaoka Y, et al. Significance of arterial ketone body ratio measurement in human liver transplantation. Transplantation. 1990;49:535
  14. Ishizaki N, Zhu Y, Zhang S, et al. Comparison of various lazaroid compound for protection against ischemic liver injury. Transplantation. 1997;63:202
  15. Kamiike W, Watanabe F, Hashimoto T, et al. Changes in cellular levels of ATP and its catabolites in ischemic rat liver. J Biochem. 1982;91:1349
  16. Todo S, Zhu Y, Zhang S, et al. Attenuation of ischemic liver injury by augmentation of endogenous adenosine. Transplantation. 1997;63:217
  17. Drugas GT, Paidas CN, Yahanda AM, et al. Conjugated desferoxamine attenuates hepatic microvascular injury following ischemia/reperfusion. Circ Shock. 1991;34:278
  18. Rounds S, Hsieh L, Agarwal KC. Effects of endotoxin injury on endothelial cell adenosine metaboism. J Lab Clin Med. 1994;123:309
  19. Bruder G, Heid H, Jarasch ED, et al. Characteristics of membrane-bound and soluble forms of xanthine oxidase from milk and endothelial cells of capillaries. Biochim Biophys Acta. 1982;701:357

 Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenadoria de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil.

PII: S0041-1345(09)00118-3

doi: 10.1016/j.transproceed.2009.01.057

Transplantation Proceedings
Volume 41, Issue 3 , Pages 807-811 , April 2009

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