Transplantation Proceedings
Volume 40, Issue 4 , Pages 918-920 , May 2008

An In Vitro System for the Determination of Individualized Immunosuppression

  • M. Linnebacher

      Affiliations

    • Department of General Surgery, University of Rostock, Rostock, Germany
    • Corresponding Author InformationAddress reprint requests to Michael Linnebacher, PhD, Molecular Oncology and Immunotherapy, Department of General Surgery, University of Rostock, Schillingallee 35, D-18055 Rostock, Germany.
    • ,
  • C. Blauscha

      Affiliations

    • Department of General Surgery, University of Rostock, Rostock, Germany
    • ,
  • R. Wacke

      Affiliations

    • Institute of Clinical Pharmacology, University of Rostock, Rostock, Germany
    • ,
  • T. Kottek

      Affiliations

    • Department of General Surgery, University of Rostock, Rostock, Germany
    • ,
  • S.v. Stein

      Affiliations

    • Department of Transfusion Medicine, University of Rostock, Rostock, Germany
    • ,
  • V. Kiefel

      Affiliations

    • Department of Transfusion Medicine, University of Rostock, Rostock, Germany
    • ,
  • O.W. Hakenberg

      Affiliations

    • Department of Urology, University of Rostock, Rostock, Germany.
    • ,
  • E. Klar

      Affiliations

    • Department of General Surgery, University of Rostock, Rostock, Germany

References 

  1. Citterio F, Scatà MC, Romagnoli J, et al. Results of a three-year prospective study of C2 monitoring in long-term renal transplant recipients receiving Ciclosporine microemulsion. Transplantation. 2005;79:802
  2. Land W. Future challenges in immunosuppression. Transplant Proc. 1998;30:1580
  3. Lyons AB, Parish CR. Determination of lymphocyte division by flow cytometry. J Immunol Methods. 1994;171:131;2
  4. Nickel P, Presber F, Bold G, et al. Enzyme-linked immunosorbent spot assay for donor-reactive interferon-gamma-producing cells identifies T-cell presensitization and correlates with graft function at 6 and 12 months in renal-transplant recipients. Transplantation. 2004;78:1640
  5. Sizzano F, Dametto E, Amoroso A. Evaluation of alloreactivity in responder-stimulator pairs by determination of gamma interferon-producing cells and cytotoxic-T-lymphocyte precursor frequencies. Clin Vaccine Immunol. 2007;14:481
  6. Préville X, Flacher M, LeMauff B, et al. Mechanisms involved in antithymocyte globulin immunosuppressive activity in a nonhuman primate model. Transplantation. 2001;71:460
  7. Michallet MC, Preville X, Flacher M, et al. Functional antibodies to leukocyte molecules in antithymocyte globulins. Transplantation. 2003;75:657
  8. Oellerich M, Armstrong VW, Kahan B, et al. Lake Louise Consensus Conference on Cyclosporine Monitoring in Organ Transplantation (Report of the Consensus Panel). Ther Drug Monit. 1995;17:642
  9. Halloran PF, Helms LM, Kung L, et al. The temporal profile of calcineurin inhibition by cyclosporine in vivo. Transplantation. 1999;68:1356

 This work was supported by a FORUN grant of the Medical Faculty of the University of Rostock.

 M.L. and C.R. contributed equally to this work.

PII: S0041-1345(08)00423-5

doi: 10.1016/j.transproceed.2008.04.006

Transplantation Proceedings
Volume 40, Issue 4 , Pages 918-920 , May 2008

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