Transplantation Proceedings
Volume 40, Issue 1 , Pages 11-15 , January 2008

Frontiers in Immunosuppression

  • B.D. Kahan

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Barry D. Kahan, PhD, MD, University of Texas Medical School at Houston 6431 Fanin, Suite 6.240, Houston, TX 77030.

References 

  1. Kahan BD, Karlix JL, Ferguson RM, et al. Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study. Transplantation. 2003;76:1079
  2. Wei SH, Rosen H, Matheu MP, et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol. 2005;6:1215
  3. Lorber MI, Mulgaonkar S, Butt KM, et al. B251 Study Group: Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: a 3-year randomized, multicenter, phase III study. Transplantation. 2005;80:244
  4. Kahan BD, Katz SM, Stepkowski SM. KRP203 displays enhanced immunosuppressive activity and selectivity as an agonist of sphingosine-1-phosphate receptor type 1 (S1P1) compared with FTY720. Am J Trans. 2007;7(suppl 2):222
  5. Pan S, Mi Y, Pally C, et al. A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006;13:1227
  6. Langer R, Wang ME, Stepkowski SM, et al. Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines. J Am Soc Nephrol. 2004;15:2893
  7. Gaber AO, Mulgaonkar S, Kahan B, et al. YSPSL (rPSGL-Ig) for the prevention of delayed graft function (DGF): preliminary results of ongoing dose escalation and efficacy study. Am J Trans. 2007;7(suppl 2):146
  8. Kahan BD. Cyclosporine. N Engl J Med. 1989;321:1725
  9. Abbott L, Betschmann P, Burchat A, et al. Discovery of thienopyridines as Src-family selective Lck inhibitors. Bioorg Med Chem Lett. 2007;17:1167
  10. Waegell W, Babineau M, Hart M, et al. A420983, a novel, small molecule inhibitor of Lck prevents allograft rejection. Transplant Proc. 2002;34:1411
  11. Burchat A, Borhani DW, Calderwood DJ, et al. Discovery of A-770041, a src-family selective orally active Lck inhibitor that prevents organ allograft rejection. Bioorg Med Chem Lett. 2006;16:118
  12. Stachlewitz RF, Hart MA, Bettencourt B, et al. A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection. J Pharmacol Exp Therapeutics. 2005;315:36
  13. Vincenti F, Larsen C, Durrbach A, et al. Costimulation blockade with belatacept in renal transplantation. N Engl J Med. 2005;353:836
  14. Weckbecker G, Jean C, Pally C, et al. Pharmacokinetics (PK) of the novel oral protein kinase C (PKC) inhibitor NVP-AEB071 (AEB) in rats and non-human primates (NHP): study of immunosuppressive (IS) efficacy and distribution to lymphatic organs. Am J Trans. 2006;6(suppl 2):768;(Abstract 2114)
  15. Podder H, Kahan BD. Janus kinase 3 (Jak3): a novel target for transplant immunosuppression. Expert Opin Ther Targets. 2004;8:613
  16. Kudlacz E, Perry B, Sawyer P, et al. The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models. Am J Transplant. 2004;4:51
  17. Borie DC, Changelian PS, Larson MJ, et al. Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates. Transplantation. 2005;79:791
  18. Busque S, Leventhal J, Brennan D, et al. CP-690,550 (CP), a JAK3 Inhibitor, in de novo kidney transplant (KT) recipients: 6-month results of a phase 2 trial. Am J Trans. 2007;7(suppl 2):601
  19. Stepkowski SM, Kao J, Wang ME, et al. The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities. J Immunol. 2005;175:4236

PII: S0041-1345(07)01470-4

doi: 10.1016/j.transproceed.2007.12.007

Transplantation Proceedings
Volume 40, Issue 1 , Pages 11-15 , January 2008

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