Transplantation Proceedings
Volume 39, Issue 10 , Pages 2992-2996 , December 2007

FTY720 Reduces Extracellular Matrix Expansion Associated With Ischemia-Reperfusion Induced Injury

References 

  1. Cornell LD, Colvin RB. Chronic allograft nephropathy. Curr Opin Nephrol Hypertens. 2005;14:229
  2. Ahsan N, Cheung JY. Pathogenesis and molecular mechanisms of chronic allograft nephropathy. Contrib Nephrol. 2003;139:187
  3. Joosten SA, Sijpkens YW, van Kooten C, et al. Chronic renal allograft rejection: pathophysiologic considerations. Kidney Int. 2005;68:1
  4. Kahan BD. Sirolimus and FTY720: new approaches to transplant immunosuppression. Transplant Proc. 2002;34:2520
  5. Joosten SA, van Kooten C, Paul LC. Pathogenesis of chronic allograft rejection. Transpl Int. 2003;16:137
  6. Cuhaci B, Kumar MS, Bloom RD, et al. Transforming growth factor-beta levels in human allograft chronic fibrosis correlate with rate of decline in renal function. Transplantation. 1999;68:785
  7. Nielson EG, Phillips SM, Jimenez S. Lymphokine modulation of fibroblast proliferation. J Immunol. 1982;128:1484
  8. Monroe JG, Haldar S, Prystowsky MB, et al. Lymphokine regulation of inflammatory processes: interleukin-4 stimulates fibroblast proliferation. Clin Immunol Immunopathol. 1988;49:292
  9. Postlethwaite AE, Holness MA, Katai H, et al. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest. 1992;90:1479
  10. Kelly CJ, Korngold R, Mann R, et al. Spontaneous interstitial nephritis in kdkd mice (II. Characterization of a tubular antigen-eferencesspecific, H-2K-restricted Lyt-2+ effector T cell that mediates destructive tubulointerstitial injury). J Immunol. 1986;136:526
  11. Kovacs EJ, Brock B, Varesio L, et al. IL-2 induction of IL-1 beta mRNA expression in monocytes (Regulation by agents that block second messenger pathways). J Immunol. 1989;143:3532
  12. Piguet PF, Collart MA, Grau GE, et al. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med. 1989;170:655
  13. Wang M, Liu S, Ouyang N, et al. Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration. Kidney Int. 2004;66:1248
  14. Peters H, Martini S, Wang Y, et al. Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis. Kidney Int. 2004;66:1434
  15. Troncoso P, Ortiz M, Martinez L, et al. FTY720 prevents ischemic reperfusion damage in rat kidneys. Transplant Proc. 2001;33:857
  16. Dragun D, Bohler T, Nieminen-Kelha M, et al. FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury. Kidney Int. 2004;65:1076

PII: S0041-1345(07)01127-X

doi: 10.1016/j.transproceed.2007.04.027

Transplantation Proceedings
Volume 39, Issue 10 , Pages 2992-2996 , December 2007

Article Tools

* Image Usage & Resolution