Transplantation Proceedings
Volume 39, Issue 8 , Pages 2501-2506 , October 2007

Dual Effect of Nitrate Therapy for Cyclosporine-Induced Hypertension on Vascular and Platelet Morphofunctional Markers; An Animal Model

  • F. Reis

      Affiliations

    • Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Coimbra University, Coimbra, Portugal
    • ,
  • E. Teixeira de Lemos

      Affiliations

    • Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Coimbra University, Coimbra, Portugal
    • Corresponding Author InformationAddress reprint requests to Prof Frederico Teixeira, Therapeutics Unit, Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Coimbra University, 3004-504 Coimbra, Portugal.
    • ,
  • L. Almeida

      Affiliations

    • Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Coimbra University, Coimbra, Portugal
    • ,
  • B. Parada

      Affiliations

    • Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Coimbra University, Coimbra, Portugal
    • Department of Urology and Renal Transplantation, Coimbra University Hospital, Coimbra, Portugal
    • ,
  • A.P. Garrido

      Affiliations

    • Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Coimbra University, Coimbra, Portugal
    • ,
  • P. Rocha-Pereira

      Affiliations

    • Chemistry Department, Beira Interior University, Covilhã, Portugal
    • Molecular and Cellular Biology Institute, Porto University, Porto, Portugal
    • ,
  • A. Santos-Silva

      Affiliations

    • Biochemistry Service, Faculty of Pharmacy, Porto University, Porto, Portugal
    • Molecular and Cellular Biology Institute, Porto University, Porto, Portugal
    • ,
  • J. Santos-Dias

      Affiliations

    • Electron Microscopy Laboratory, Botanic Department, Faculty of Science and Technology, Coimbra University, Coimbra, Portugal.
    • ,
  • A. Dinis

      Affiliations

    • Electron Microscopy Laboratory, Botanic Department, Faculty of Science and Technology, Coimbra University, Coimbra, Portugal.
    • ,
  • A. Figueiredo

      Affiliations

    • Department of Urology and Renal Transplantation, Coimbra University Hospital, Coimbra, Portugal
    • ,
  • C. Costa-Almeida

      Affiliations

    • Institute of Physiology, Faculty of Medicine, Coimbra University, Coimbra, Portugal
    • ,
  • A. Mota

      Affiliations

    • Department of Urology and Renal Transplantation, Coimbra University Hospital, Coimbra, Portugal
    • ,
  • F. Teixeira

      Affiliations

    • Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Coimbra University, Coimbra, Portugal

References 

  1. Cortesini R. Cyclosporine—lessons from the first 20 years. Transplant Proc. 2004;36(2 suppl):158S
  2. Vitko S, Viklicky O. Cyclosporine renal dysfunction. Transplant Proc. 2004;36(2 suppl):243S
  3. Taler SJ, Textor SC, Canzanello VJ, et al. Cyclosporin-induced hypertension: incidence, pathogenesis and management. Drug Saf. 1999;20:437
  4. Textor SC, Taler SJ, Canzanello VJ, et al. Posttransplantation hypertension related to calcineurin inhibitors. Liver Transpl. 2000;6:521
  5. Kokado Y, Takahara S, Kamoeka H, et al. Hypertension in renal transplant recipients and its effect on long-term renal allograft survival. Transplant Proc. 1996;28:1600
  6. Cosio FG, Falhenhain ME, Pesavento TE, et al. Relationship between arterial hypertension and renal allograft survival in African-American patients. Am J Kidney Dis. 1997;29:419
  7. Olyaei AJ, de Mattos AM, Bennett WM. A practical guide to the management of hypertension in renal transplant recipients. Drugs. 1999;58:1011
  8. Cartier R, Dagenais F, Hollmann C, et al. Chronic exposure to cyclosporine affects endothelial and smooth muscle reactivity in the rat aorta. Ann Thorac Surg. 1994;58:789
  9. Vaziri ND, Ni Z, Zhang YP, et al. Depressed renal and vascular nitric oxide synthase expression in cyclosporine-induced hypertension. Kidney Int. 1998;54:482
  10. Santiago M, Reis F, Almeida L, et al. Impairment of vascular and platelet nitric oxide and 3′, 5′ cyclic guanosine monophosphate content in cyclosporine A-induced hypertensive rats. Fund Clin Pharmacol. 2003;17:43
  11. Oriji GK, Keiser HR. Role of nitric oxide in cyclosporine A-induced hypertension. Hypertension. 1998;32:849
  12. Anderson TJ. Nitric oxide, atherosclerosis and the clinical relevance of endothelial dysfunction. Heart Fail Rev. 2003;8:71
  13. Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res. 2001;88:756
  14. Reis F, Santiago M, Almeida L, et al. Isosorbide-5-mononitrate and L-arginine effect on the cyclosporin-induced arterial hypertension and vascular nitric oxide impairment. In:  Tooke J,  Shore A,  Whatmore J editor. The Microcirculation and Vascular Biology. Bologna: Italy Monduzzi Editore S.p.A; 2002;p. 257
  15. Lassila M, Santisteban J, Finckenberg P, et al. Vascular changes in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet. J Physiol Pharmacol. 2001;52:21
  16. Gunasekara NS, Noble S. Isosorbide 5-mononitrate (A review of a sustained-release formulation (Indur) in stable angina pectoris). Drugs. 1999;57:261
  17. Parker JO. Angina pectoris: a review of current and emerging therapies. Am J Manag Care. 2004;10(11 suppl):S332
  18. Reis F, Tavares P, Fontes-Ribeiro CA, et al. The peripheral serotonergic system and platelet aggregation in cyclosporin A-induced hypertensive rats. Thromb Res. 1999;96:365
  19. Martin A, Wong KS, Li M, et al. Cyclosporin hypertension in the Wistar rat: role of uninephrectomy. Clin Exp Pharmacol Physiol. 1994;21:287
  20. Reis F, Tavares P, Rito LC, et al. Platelet activation is increased in cyclosporin A-induced hypertensive rats. J Cardiovasc Pharmacol. 2000;36:56
  21. Channon KM, Guzik TJ. Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors. J Physiol Pharmacol. 2002;53:515
  22. Brown AS, Moro MA, Masse JM, et al. Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite. Cardiovasc Res. 1998;40:380

PII: S0041-1345(07)00864-0

doi: 10.1016/j.transproceed.2007.07.029

Transplantation Proceedings
Volume 39, Issue 8 , Pages 2501-2506 , October 2007

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