Transplantation Proceedings
Volume 39, Issue 6 , Pages 1765-1767 , July 2007

Subnormothermic Machine Perfusion Protects Against Rat Liver Preservation Injury: A Comparative Evaluation With Conventional Cold Storage

  • M. Vairetti

      Affiliations

    • Department of Internal Medicine and Therapeutics, San Matteo
    • Corresponding Author InformationAddress reprint requests to Dr Mariapia Vairetti, Department Internal Medicine and Therapeutics, University of Pavia, Piazza Botta, 10, 27100 Pavia, Italy.
    • ,
  • A. Ferrigno

      Affiliations

    • Department of Internal Medicine and Therapeutics, San Matteo
    • ,
  • V. Rizzo

      Affiliations

    • Biochemistry, IRCCS Policlinico San Matteo, San Matteo
    • ,
  • P. Richelmi

      Affiliations

    • Department of Internal Medicine and Therapeutics, San Matteo
    • ,
  • E. Boncompagni

      Affiliations

    • Animal Biology, University of Pavia, Pavia
    • ,
  • D. Neri

      Affiliations

    • Department I General Surgery, University of Padua, Padua, Italy.
    • ,
  • I. Freitas

      Affiliations

    • Animal Biology, University of Pavia, Pavia
    • ,
  • U. Cillo

      Affiliations

    • Department I General Surgery, University of Padua, Padua, Italy.

References 

  1. Bessems M, Doorschodt BM, van Marle J, et al. Improved machine perfusion preservation of the non-heart-beating donor rat liver using Polysol: a new machine perfusion preservation solution. Liver Transpl. 2005;11:1379
  2. Menger MD, Vollmar B. Role of microcirculation in transplantation. Microcirculation. 2000;7:291
  3. Arnault I, Bao YM, Sebagh M, et al. Beneficial effect of pentoxifylline on microvascular steatotic liver submitted to a prolonged cold ischemia. Transplantation. 2003;76:77
  4. Lowry HO, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;53:265
  5. Khandoga A, Enders G, Luching B, et al. Impact of intraischemic temperature on oxidative stress during hepatic reperfusion. Free Radic Biol Med. 2003;35:901
  6. Biberthaler P, Luchting B, Massberg S, et al. The influence of organ temperature on hepatic ischemia-reperfusion injury. Transplantation. 2001;72:1486
  7. Rubinski B. Principles of low temperature cell preservation. Heart Fail Rev. 2003;8:277
  8. Fujita S, Hamamoto I, Nakamura K, et al. Isolated perfusion of rat livers: effect of temperature on O2 consumption, enzyme release, energy store, and morphology. Nippon Geka Hokan. 1993;62:58

 Supported by MIUR-COFIN 2004.

PII: S0041-1345(07)00710-5

doi: 10.1016/j.transproceed.2007.06.002

Transplantation Proceedings
Volume 39, Issue 6 , Pages 1765-1767 , July 2007

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