Transplantation Proceedings
Volume 39, Issue 6 , Pages 1768-1770 , July 2007

Liver Damage During Ischemia/Reperfusion and Glutathione: Implications for Potential Organ Donors

  • M. Vairetti

      Affiliations

    • Department of Internal Medicine and Therapeutics, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    • Corresponding Author InformationAddress reprint requests to Dr Mariapia Vairetti, Department Internal Medicine and Therapeutics, University of Pavia, Piazza Botta, 10, 27100 Pavia, Italy.
    • ,
  • A. Ferrigno

      Affiliations

    • Department of Internal Medicine and Therapeutics, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    • ,
  • V. Rizzo

      Affiliations

    • Department of Biochemistry, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    • ,
  • P. Richelmi

      Affiliations

    • Department of Internal Medicine and Therapeutics, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    • ,
  • U. Cillo

      Affiliations

    • Department I of General Surgery, University of Padua, Padua, Italy.
    • ,
  • R. Imberti

      Affiliations

    • Department of Rianimazione II, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy

References 

  1. Novitzky D, Cooper DK, Reichart B. Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation. 1987;43:852
  2. Tieze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissue. Anal Biochem. 1969;27:502
  3. Imberti R, Vairetti M, Gualea MR, et al. The effects of thyroid hormone modulation on rat liver injury associated with ischemia-reperfusion and cold storage. Anesth Analg. 1998;86:1187
  4. Pérez-Blanco A, Caturla-Such J, Cánovas-Robles J, et al. Efficiency of triiodothyronine treatment on organ donor hemodynamic management and adenine nucleotide concentration. Intensive Care Med. 2005;31:943
  5. Castilho RF, Kowaltowski AJ, Vercesi AE. 3,5,3′-Triiodothyronine induces mitochondrial permeability transition mediated by reactive oxygen species and membrane thiol oxidation. Arch Biochem Biophys. 1998;354:151
  6. Paller MS. Hypothyroidism protects against free radical damage in ischemic acute renal failure. Kidney Int. 1986;29:1162
  7. Shuaib A, Ijaz S, Mazagri R, et al. Hypothyroidism protects the brain during transient forebrain ischemia in gerbils. Exp Neurol. 1994;127:119
  8. Sener G, Kabasakal L, Atasoy BM, et al. Propylthiouracil-induced hypothyroidism protects ionizing radiation-induced multiple organ damage in rats. J Endocrinol. 2006;189:257

 Supported by MIUR-COFIN 2004.

PII: S0041-1345(07)00709-9

doi: 10.1016/j.transproceed.2007.06.001

Transplantation Proceedings
Volume 39, Issue 6 , Pages 1768-1770 , July 2007

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