Algorithm for Prioritization of Patients on the Waiting List for Liver Transplantation

Gambato, M.; Senzolo, M.; Canova, D.; Germani, G.; Tomat, S.; Masier, A.; Russo, F.P.; Perissinotto, E.; Zanus, G.; Cillo, U.; Burra, P.

doi:10.1016/j.transproceed.2007.05.059

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Volume 39, Issue 6 , Pages 1855-1856, July 2007

Algorithm for Prioritization of Patients on the Waiting List for Liver Transplantation

M. Gambato
- Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
M. Senzolo
- Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
D. Canova
- Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
G. Germani
- Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
S. Tomat
- Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
A. Masier
- Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
F.P. Russo
- Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
E. Perissinotto
- Department of Environmental Medicine and Public Health, University of Padua, Padua, Italy.
G. Zanus
- Surgical Clinic, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
U. Cillo
- Surgical Clinic, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
P. Burra
- Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
- Address reprint requests to Dr. Patrizia Burra, Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padua, Via Giustiniani n. 2, 35128, Padua, Italy.

Abstract

Prioritization of patients on the waiting list (WL) for OLT is still a critical issue. Numerous models have been developed to predict mortality before and after OLT.

Aim

The aim of the study was to prospectively evaluate cirrhotics with and without hepatocellular carcinoma (HCC) undergoing orthotopic liver transplantation (OLT) severity of liver disease on the WL and at transplant, mortality on the WL and after OLT, and their correlations.

Materials and methods

An algorithm based on seven patient variables (MELD, CTP, UNOS, HCC, BMI, waiting time, age) was created by software dedicated to prioritize patients on the waiting list.

Results

We evaluated 118 patients including 75 men and 43 women of age range 19 to 66 years, who underwent OLT from July 2004 to June 2006. Mean CTP and MELD at listing were 8.44 (range 6–12) and 13 (range 2–24), respectively. Overall mortality on the WL at 24 months was 13%, which was significantly higher among patients with MELD > 25 compared to patients with MELD 0 to 15 (P < .0001) or MELD 16 to 25 (P = .0007) at listing. Mean MELD at OLT was 15 (range 7–36), which was significantly lower in patients with than without HCC (MELD 12 vs 16; P = .0003). Six hundred-day patient survival was significantly lower among patients with MELD > 25 compared to patients with MELD < 25 at OLT (P = .017), whereas no difference in survival was observed between patients with and without HCC.

Conclusions

The sickest patients are characterized by high mortality both on the waiting list and after liver transplantation. Patients with HCC are transplanted in better condition compared to patients without HCC with the same survival.