Transplantation Proceedings
Volume 39, Issue 6 , Pages 1761-1764 , July 2007

Inhibition of Tumor Necrosis Factor Alpha Gene Transcription by Pentoxifylline Reduces Normothermic Liver Ischemia-Reperfusion Injury in Rats

  • A. El-Ghoneimi

      Affiliations

    • Laboratoire de Recherches Chirurgicales, IFR 50, Faculté de Médecine, Université de Nice Sophia Antipolis, Nice, France
    • Service de Chirurgie Uro-Génitale Pediatrique, Hôpital Robert Dubré, Paris, France.
    • ,
  • R. Cursio

      Affiliations

    • Laboratoire de Recherches Chirurgicales, IFR 50, Faculté de Médecine, Université de Nice Sophia Antipolis, Nice, France
    • Corresponding Author InformationAddress reprint requests to Dr Raffaele Cursio, Laboratoire de Recherches Chirurgicales, Faculté de Médecine, Université de Nice, Sophia Antipolis, 28, avenue de Valombrose, 06107 Nice, France.
    • ,
  • A. Schmid-Alliana

      Affiliations

    • Unité de Recherches en Immunologie Cellulaire et Moléculaire, INSERM U364, IFR 50, Faculté de Médecine, Université de Nice Sophia Antipolis, Nice, France
    • ,
  • M. Tovey

      Affiliations

    • Laboratoire d’Oncologie Virale, UPR 274, CNRS, Villejiuf, France
    • ,
  • A. Lasfar

      Affiliations

    • Laboratoire d’Oncologie Virale, UPR 274, CNRS, Villejiuf, France
    • ,
  • J.-F. Michiels

      Affiliations

    • Service d’Anatomo-pathologie, Hôpital Pasteur, Université de Nice Sophia Antipolis, Nice, France
    • ,
  • B. Rossi

      Affiliations

    • Unité de Recherches en Immunologie Cellulaire et Moléculaire, INSERM U364, IFR 50, Faculté de Médecine, Université de Nice Sophia Antipolis, Nice, France
    • ,
  • J. Gugenheim

      Affiliations

    • Laboratoire de Recherches Chirurgicales, IFR 50, Faculté de Médecine, Université de Nice Sophia Antipolis, Nice, France

References 

  1. Selzner N, Rudiger H, Graf R, et al. Protective strategies against ischemic injury of the liver. Gastroenterology. 2003;125:917
  2. Jaeshke H, Farhood A. Neutrophils and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol. 1991;260:t-62
  3. Ward A, Clissold SP. Pentoxifylline (A review of its pharmacodynamic and pharmacokinetic properties and its therapeutic efficacy). Drugs. 1987;34:50
  4. Kozaki K, Matsuno N, Kozaki M. Beneficial effects of pentoxifylline and propentoxifylline on preservation-reperfusion injury in rat liver transplantation. Transplant Proc. 1996;28:333
  5. Kozaki K, Egawa H, Bermudes L, et al. Effect of pentoxifylline pretreatment on Kupffer cels in rat liver transplantation. Hepatology. 1995;121:1079
  6. Astarciouglu H, Karademir S, Unek T, et al. Beneficial effects of pentoxifylline pretreatment in non-heart-beating donors in rats. Transplantation. 2000;69:93
  7. Fabia R, Travis DL, Levy MF, et al. Effect of pentoxifylline on hepatic ischemia and reperfusion injury. Surgery. 1997;121:520
  8. Iwamoto H, Kozaki N, Nakamura K, et al. Beneficial effects of pentoxifylline and propentoxifylline on the warm ischemic injury of rat livers. Transplant Proc. 2002;34:2677
  9. Cursio R, Gugenheim J, Panata-Ferrari P, et al. Improvement of normothermic rat liver ischemia/reperfusion by muramyl dipeptide. J Surg Res. 1998;80:339
  10. Nishimura T, Yoshida Y, Watanabe F, et al. Blood level of mitochondrial aspartate aminotransferases as an indicator of the extent of ischemic necrosis of the rat liver. Hepatology. 1986;6:701
  11. Asakawa H, Jeppsson B, Mack P, et al. Acute ischemic liver failure in the rat: a reproducible model not requiring portal decompression. Eur Surg Res. 1989;21:42
  12. Nishizawa H, Egawa H, Inomata Y, et al. Efficiency of pentoxifylline in donor pretreatment in rat liver transplantation. J Surg Res. 1997;72:170
  13. Chirgwin JM, Przybyla AE, Macdonald RJ, et al. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 1979;18:5294
  14. Caput D, Beutler B, Thayer R, et al. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci U S A. 1986;83:1670
  15. Adams J, Dhar A, Shukla S, et al. Effect of pentoxifylline on tissue injury and platelet-activating factor production during ischemia-reperfusion injury. J Vasc Surg. 1995;21:742
  16. Colletti LM, Remick DG, Burtch GD, et al. Role of tumor necrosis factor-alpha in the pathophysiologic alteration after hepatic ischemia/reperfusion injury in the rat. J Clin Invest. 1990;85:1936
  17. Schlayer HJ, Laaff H, Peters T, et al. Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal cells of mouce liver and its modulation in acute phase. J Hepatol. 1988;7:239
  18. Bevilacqua MP, Pober JS, Majeau GR, et al. Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium. Proc Natl Acad Sci U S A. 1988;83:4533
  19. Doherty GM, Jensen JC, Alexander HR, et al. Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery. 1991;110:192

PII: S0041-1345(07)00596-9

doi: 10.1016/j.transproceed.2007.05.017

Transplantation Proceedings
Volume 39, Issue 6 , Pages 1761-1764 , July 2007

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