Oral Ulcers Produced by Mycophenolate Mofetil in Two Liver Transplant Patients

Naranjo, J.; Poniachik, J.; Cisco, D.; Contreras, J.; Oksenberg, D.; Valera, J.M.; Díaz, J.C.; Rojas, J.; Cardemil, G.; Mena, S.; Castillo, J.; Rencoret, G.; Godoy, J.; Escobar, J.; Rodríguez, J.; Leyton, P.; Fica, A.; Toledo, C.

doi:10.1016/j.transproceed.2006.12.028

« Previous Next »Transplantation Proceedings
Volume 39, Issue 3 , Pages 612-614, April 2007

Oral Ulcers Produced by Mycophenolate Mofetil in Two Liver Transplant Patients

J. Naranjo
- Gastroenterology Department, Medicine Service, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile
- Address reprint requests to J. Naranjo, Clinical Hospital of the University of Chile, Santos Dumont 999, Independencia, Santiago, Chile.
J. Poniachik
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
D. Cisco
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
J. Contreras
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
D. Oksenberg
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
J.M. Valera
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
J.C. Díaz
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
J. Rojas
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
G. Cardemil
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
S. Mena
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
J. Castillo
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
G. Rencoret
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
J. Godoy
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
J. Escobar
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
J. Rodríguez
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
P. Leyton
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
A. Fica
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.
C. Toledo
- Transplant Unit, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile.

Abstract

Oral ulcers are a frequent problem in transplant medicine. It is important to consider infectious etiologies, exacerbated by the immunosuppressive treatment, but other etiologies are also possible, like adverse drug reactions. Mycophenolate mofetil (MMF) is an immunosuppressive medication that has been used in combination with calcineurin inhibitors and steroids. Reports of renal transplant patients with oral ulcers related to MMF have appeared lately and herein we have described 2 cases in liver transplant patients. Their oral ulcers resolved quickly after suspension of the medication. Our 2 cases in liver transplant patients represented a unique setting for this type of complication.