Transplantation Proceedings
Volume 39, Issue 3 , Pages 596-599 , April 2007

Therapeutic Drug Monitoring of Mycophenolic Acid in Kidney Transplant Patients: A Abbreviated Sampling Strategy

  • H. Muller

      Affiliations

    • Transplant Unit, Higueras Hospital, Talcahuano, Chile
    • Department of Internal Medicine, Faculty of Medicine, Universidad Catolica Santisima Concepcion, Concepcion, Chile
    • Corresponding Author InformationAddress reprint requests to Hans Muller, MD, Department of Internal Medicine, Faculty of Medicine, Universidad Catolica Santisima Concepcion, Concepcion, Chile.
    • ,
  • S. Solari

      Affiliations

    • Academic Unit, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
    • ,
  • C. Zuniga

      Affiliations

    • Department of Internal Medicine, Faculty of Medicine, Universidad Catolica Santisima Concepcion, Concepcion, Chile
    • ,
  • I. Guerra

      Affiliations

    • Academic Unit, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
    • ,
  • J. Troncoso

      Affiliations

    • Transplant Unit, Higueras Hospital, Talcahuano, Chile
    • ,
  • R. Ovalle

      Affiliations

    • Transplant Unit, Higueras Hospital, Talcahuano, Chile
    • ,
  • J. Morente

      Affiliations

    • Transplant Unit, Higueras Hospital, Talcahuano, Chile
    • ,
  • C. Pedreros

      Affiliations

    • Transplant Unit, Higueras Hospital, Talcahuano, Chile

References 

  1. Allison AC, Eugui FM. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev. 1995;136:5
  2. Sollinger HW US Renal Transplant Mycophenolate Mofetil Study Group. Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric allograft recipients. Transplantation. 1995;60:225
  3. Ojo AO, Meier-Kriesche HU, Hanson JA, et al. Mycophenolate mofetil reduces late allograft loss independent of acute rejection. Transplantation. 2000;69:2405
  4. The Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group. A blinded randomized clinical trial of mycophenolate mofetil for the prevention of cadaveric renal transplantation. Transplantation. 1996;61:1029
  5. Vanrenterghem Y, Lebranchu Y, Hene R, et al. Double-blind comparison of two corticosteroid regimens plus mycophenolate mofetil and cyclosporin for prevention of acute renal allograft rejection. Transplantation. 2000;70:1352
  6. Houde I, Isenring P, Bouche D, et al. Mycophenolate mofetil, an alternative to cyclosporine A for long-term immunosuppression in kidney transplantation. Transplantation. 2000;70:1251
  7. Shaw C, Korecka M, Brayman L. Pharmacokinetic-pharmacodynamic relationship for mycophenolic acid in renal transplant patients. Graft. 1994;2:597
  8. Bullingham RE, Nicholls AJ, Kamm BR. Clinical pharmacokinetics of mycophenolate mofetil. Clin Pharmacokin. 1998;34:429
  9. van Gelder T, Hilbrands LB, Varenterghem Y, et al. A randomized double blind, multicenter plasma concentration controlled study of the safety and efficacy of oral mycophenolate mofetil for the prevention of acute rejection after kidney transplantation. Transplantation. 1999;68:261
  10. Shaw LM, Kaplan B, DeNofrio D, et al. Pharmacokinetic and concentration-control investigation of mycophenolic acid in adults after transplantation. Ther Drug Monit. 2000;22:14
  11. Yeung S, Tong KL, Tsang WK, et al. Determinatiuon of mycophenolate area under the curve by limited sampling strategy. Transplant Proc. 2001;33:1052
  12. Filler G, Mai I. Limited sampling strategy for mycophenolic acid area under the curve. Ther Drug Monit. 2000;22:169
  13. Filler G, Feber J, Lepage N, et al. Universal approach to pharmacokinetic monitoring of immunosuppressive agents in children. Pediatr Transplant. 2002;6:411
  14. Johnson AG, Rigby RJ, Taylor PJ, et al. The kinetics of mycophenolic acid and its glucuronide metabolite in adult kidney transplant recipients. Clin Pharmacol Ther. 1999;66:492

PII: S0041-1345(06)01574-0

doi: 10.1016/j.transproceed.2006.12.027

Transplantation Proceedings
Volume 39, Issue 3 , Pages 596-599 , April 2007

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