Transplantation Proceedings
Volume 38, Issue 9 , Pages 2774-2776 , November 2006

Beneficial Effect of N-Acetyl-Cysteine on Renal Injury Triggered by Ischemia and Reperfusion

References 

  1. Rabb H. The T cell as a bridge between innate and adaptive immune systems: implications for the kidney. Kidney Int. 2002;61:1935
  2. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312:159
  3. Honda HM, Korge P, Weiss JN. Mitochondria and ischemia/reperfusion injury. Ann NY Acad Sci. 2005;1047:248
  4. Dobashi K, Singh I, Orak JK, et al. Combination therapy of N-acetylcysteinee, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney. Mol Cell Biochem. 2002;240:9
  5. Ozdulger A, Cinel I, Koksel O, et al. The protective effect of N-acetylcysteinee on apoptotic lung injury in cecal ligation and puncture-induced sepsis model. Shock. 2003;19:366
  6. Cotgreave IA. N-acetylcysteinee: pharmacological considerations and experimental and clinical applications. Adv Pharmacol. 1997;38:205
  7. Tian H, Zhang Q, Li H, et al. Antioxidant N-acetylcysteinee and AMPA/KA receptor antagonist DNQX inhibited mixed lineage kinase-3 activation following cerebral ischemia in rat hippocampus. Neurosci Res. 2003;47:47
  8. Iijima N, Yanagawa Y, Iwabuchi K, et al. Selective regulation of CD40 expression in murine dendritic cells by thiol antioxidants. Immunology. 2003;110:197
  9. Mazzeo D, Sacco S, Di Lucia P, et al. Thiol antioxidants inhibit the formation of the interleukin-12 heterodimer: a novel mechanism for the inhibition of IL-12 production. Cytokine. 2002;17:285
  10. Verhasselt V, Vanden Berghe W, Vanderheyde N, et al. N-acetyl-L-cysteinee inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition. J Immunol. 1999;162:2569
  11. Witko-Sarsat V, Gausson V, Nguyen AT, et al. AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteinee treatment in dialysis patients. Kidney Int. 2003;64:82
  12. Friedman AN, Bostom AG, Laliberty P, et al. The effect of N-acetylcysteinee on plasma total homocysteine levels in hemodialysis: a randomized, controlled study. Am J Kidney Dis. 2003;41:442
  13. DiMari J, Megyesi J, Udvarhelyi N, et al. N-acetyl cysteinee ameliorates ischemic renal failure. Am J Physiol. 1997;272:F292
  14. Kaur H, Satyanarayana PS, Chopra K. Effect of U-74500A, a 21-aminosteroid on renal ischemia-reperfusion injury in rats. Ren Fail. 2003;25:157

PII: S0041-1345(06)01118-3

doi: 10.1016/j.transproceed.2006.08.178

Transplantation Proceedings
Volume 38, Issue 9 , Pages 2774-2776 , November 2006

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