Transplantation Proceedings
Volume 38, Issue 5 , Pages 1253-1258 , June 2006

Effect of Combining Phosphodiesterase III Inhibitors With St Thomas Hospital’s Solution Used as Transplantation Preservative Solution in Isolated Rat Hearts

  • K. Besirli

      Affiliations

    • Department of Cardiovascular Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    • Corresponding Author InformationAddress reprint requests to Kazim Besirli, MD, Nevbahar Mah, Darussifa Sok, 15/9 Findikzade, Istanbul, Turkey.
    • ,
  • S.M. Burhani

      Affiliations

    • Department of Cardiovascular Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    • ,
  • C. Arslan

      Affiliations

    • Department of Cardiovascular Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    • ,
  • O. Suzer

      Affiliations

    • Department of Pharmacology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    • ,
  • A.G. Sayin

      Affiliations

    • Department of Cardiovascular Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

References 

  1. Suzer O , Koseoglu S , Han G . No beneficial effects of isocolloidoosmotic synthetic colloid addition to St. Thomas Hospital cardioplegic solution in ischemia-reperfusion injury in isolated perfused rat hearts . Gen Pharmacol . 1999;32:101
  2. Drewnowska K , Clemo HF , Baumgarten CM . Prevention of myocardial intracellular edema induced by St. Thomas’ Hospital cardioplegic solution . J Mol Cell Cardiol . 1991;23:1215
  3. Hsu DT , Weng ZC , Nicolosi AC , et al.   Quantitative effects of myocardial edema on the left ventricular pressure-volume relation. Influence of cardioplegia osmolarity over two hours of ischemic arrest . J Thorac Cardiovasc Surg . 1993;106:651
  4. Michel P , Vial R , Rodriguez C , et al.   A comparative study of the most widely used solutions for cardiac graft preservation during hypothermia . J Heart Lung Transplant . 2002;21:1030
  5. Levy JH , Bailey JM , Deeb GM . Intravenous milrinone in cardiac surgery . Ann Thorac Surg . 2002;73:325
  6. Silver PJ . Biochemical aspects of inhibition of cardiovascular low (Km) cyclic adenosine monophosphate phosphodiesterase . Am J Cardiol . 1989;63:2A
  7. Walsh MP , Kargacin GJ , Kendrick-Jones J , et al.   Intracellular mechanisms involved in the regulation of vascular smooth muscle tone . Can J Physiol Pharmacol . 1995;73:565
  8. Murray KJ . Cyclic AMP and mechanisms of vasodilation . Pharmacol Ther . 1990;47:329
  9. Rump A , Acar D , Klaus W . A quantitative comparison of functional and anti-ischaemic effects of the phosphodiesterase-inhibitors, amrinone, milrinone and levosimendan in rabbit isolated hearts . Br J Pharmacol . 1994;112:757
  10. Rechtman MP , Van derZypp A , Majewski H . Amrinone reduces ischaemia-reperfusion injury in rat heart . Eur J Pharmacol . 2000;402:255
  11. Suzer O , Bozkurt AK , Suzer A , et al.   Izole kobay kalplerinde iskemik arrest sonrasi levosimendan ve amrinonun inotropik etkilerinin karsilastirilmasi . Gogus Kalp Damar Cerrahisi Dergisi . 1996;4:4
  12. Suzer O , Bozkurt AK , Suzer A , et al.   Levosimendan is a more potent inotropic agent than amrinone after ischemia in isolated perfused guinea pig hearts . Br J Anaesth . 1996;76(suppl 1):A9
  13. Honerjager P . Pharmacology of bipyridine phosphodiesterase III inhibitors . Am Heart J . 1991;121(part 2):1939
  14. Katzung BG , Parmley WW . Cardiac glycosides & other drugs used in congestive heart failure . In:  Katzung BG ,  Parmley WW editor. Basic and Clinical Pharmacology . 5th ed.. East Norwalk, Conn: Lange; 1996;p. 197
  15. Lowes BD , Higginbotham M , Petrovich L , et al.  Enoximonee Study Group   Low-dose enoximone improves exercise capacity in chronic heart failure . J Am Coll Cardiol . 2000;36:501
  16. Mitrovic V , Strasser R , Berwing K , et al.   Acute effects of enoximone after intracoronary administration on hemodynamics, myocardial perfusion and regional wall motion . Z Kardiol . 1996;85:856
  17. Koksal C , Suzer O , Bozkurt AK , et al.   Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas’ hospital cardioplegic solutions used for myocardial preservation in isolated Guinea pig hearts . Acta Medica (Hradec Kralove) . 2002;45:93
  18. Saltman AE , Gaudette GR , Levitsky S , et al.   Amrinone preconditioning in the isolated perfused rabbit heart . Ann Thorac Surg . 2000;70:609
  19. Doyle AR , Dhir AK , Moors AH , et al.   Treatment of preoperative low cardiac output syndrome . Ann Thorac Surg . 1995;59:S3
  20. Mikawa K , Akamatsu H , Nishina K , et al.   The effect of phosphodiesterase III inhibitors on human neutrophil function . Crit Care Med . 2000;28:1001
  21. Feathersone RL , Chambers DJ , Kelly FJ . Comparison of phosphodiesterase inhibitors of differing isoenzyme selectivity added to St. Thomas Hospital cardioplegic solution used for hypothermic preservation of rat lungs . Am J Respir Crit Care Med . 2000;162:850
  22. Takeuchi K , del Nido PJ , Ibrahim AE , et al.   Vesnarinone and amrinone reduce the systemic inflammatory response syndrome . J Thorac Cardiovasc Surg . 1999;117:375
  23. Chang-Chun C , Matsuda H , Sawa Y , et al.   Effect of cyclic adenosine monophosphate phosphodiesterase inhibitor, DN-9693, on myocardial reperfusion injury . Ann Thorac Surg . 1991;52:495

PII: S0041-1345(06)00152-7

doi: 10.1016/j.transproceed.2006.02.062

Transplantation Proceedings
Volume 38, Issue 5 , Pages 1253-1258 , June 2006

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