Transplantation Proceedings
Volume 38, Issue 3 , Pages 766-770 , April 2006

Antiproliferative and Overadditive Effects of Everolimus and Mycophenolate Mofetil in Pancreas and Lung Cancer Cells In Vitro

  • S. Stracke

      Affiliations

    • Division of Nephrology, University Hospital Ulm, Ulm, Germany
    • Department of Visceral and Transplant Surgery, University Hospital Ulm, Ulm, Germany
    • Corresponding Author InformationAddress reprint requests to Sylvia Stracke, MD, Division of Nephrology, University Hospital Ulm, Robert-Koch-Strasse 8, 89081 Ulm, Germany
    • ,
  • L. Ramudo

      Affiliations

    • Division of Nephrology, University Hospital Ulm, Ulm, Germany
    • Department of Visceral and Transplant Surgery, University Hospital Ulm, Ulm, Germany
    • ,
  • F. Keller

      Affiliations

    • Division of Nephrology, University Hospital Ulm, Ulm, Germany
    • ,
  • D. Henne-Bruns

      Affiliations

    • Department of Visceral and Transplant Surgery, University Hospital Ulm, Ulm, Germany
    • ,
  • J.M. Mayer

      Affiliations

    • Department of Visceral and Transplant Surgery, University Hospital Ulm, Ulm, Germany

References 

  1. Lutz J , Heemann U . Tumors after kidney transplantation . Curr Opin Urol . 2003;13:105
  2. Penn I . Cancers in renal transplant recipients . Adv Ren Repl Ther . 2000;7:147
  3. Eisen HJ , Tuzcu EM , Dorent R , et al.  RAD B253 Study Group   Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients . N Engl J Med . 2003;349:847
  4. Voisard R , Geçgüner L , Baur R , et al.   Antiproliferative profile of sirolimus and mycophenolate mofetil (impact of the SI/MPL ratio) . Int J Cardiol . 2005;102:435
  5. Boulay A , Zumstein-Mecker S , Stephan C , et al.   Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells . Cancer Res . 2004;64:252
  6. Silva SL , Silva SF , Cavalcante RO , et al.   Mycophenolate mofetil attenuates Walker’s tumor growth when used alone, but the effect is lost when associated with cyclosporine . Transplant Proc . 2004;36:1004
  7. Engl T , Makarević J , Relja B , et al.   Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor cells (impact on tumor recurrence and malignancy) . BMC Cancer . 2005;5:1
  8. Hidalgo M , Rowinsky EK . The rapamycin-sensitive signal transduction pathway as a target for cancer therapy . Oncogene . 2000;19:6680
  9. Grewe M , Gansauge F , Schmid RM , et al.   Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells . Cancer Res . 1999;59:3581
  10. Huang S , Houghton PJ . Inhibitors of mammalian target of rapamycin as novel antitumor agents (from bench to clinic) . Curr Opin Invest Drugs . 2002;3:295
  11. Leckel K , Beecken WD , Jonas D , et al.   The immunosuppressive drug mycophenolate mofetil impairs the adhesion capacity of gastrointestinal tumour cells . Clin Exp Immunol . 2003;134:238

 This study was supported by a grant from Novartis to L.R.

PII: S0041-1345(06)00031-5

doi: 10.1016/j.transproceed.2006.01.030

Transplantation Proceedings
Volume 38, Issue 3 , Pages 766-770 , April 2006

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