Transplantation Proceedings
Volume 38, Issue 1 , Pages 35-38 , January 2006

Hypoxanthine as a Graft Ischemia Marker Stimulates Catalase Activity in the Renal Vein During Reperfusion in Humans

  • L. Domański

      Affiliations

    • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    • Corresponding Author InformationAddress reprint requests to Leszek Domański, Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, ul. Powst. Wielkopolskich 72, 70-111 Szczecin, Poland
    • ,
  • K. Safranow

      Affiliations

    • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    • ,
  • B. Dołȩgowska

      Affiliations

    • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    • ,
  • J. Różański

      Affiliations

    • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    • ,
  • M. Myślak

      Affiliations

    • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    • ,
  • K. Ciechanowski

      Affiliations

    • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    • ,
  • K. Jakubowska

      Affiliations

    • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    • ,
  • V. Dziedziejko

      Affiliations

    • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    • ,
  • M. Romanowski

      Affiliations

    • Clinic of General and Transplant Surgery, Pomeranian Medical University, Szczecin, Poland
    • ,
  • T. Sulikowski

      Affiliations

    • Clinic of General and Transplant Surgery, Pomeranian Medical University, Szczecin, Poland
    • ,
  • J. Sieńko

      Affiliations

    • Clinic of General and Transplant Surgery, Pomeranian Medical University, Szczecin, Poland
    • ,
  • M. Kamiński

      Affiliations

    • Clinic of General and Transplant Surgery, Pomeranian Medical University, Szczecin, Poland
    • ,
  • M. Ostrowski

      Affiliations

    • Clinic of General and Transplant Surgery, Pomeranian Medical University, Szczecin, Poland
    • ,
  • M. Domański

      Affiliations

    • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    • ,
  • A. Pawlik

      Affiliations

    • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    • ,
  • M.E. Rać

      Affiliations

    • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    • ,
  • D. Chlubek

      Affiliations

    • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland

References 

  1. Tilney NL , Paz D , Ames J . Ischemia reperfusion injury . Transplant Proc . 2001;33:843
  2. Chien CT , Lee PH , Chen CF , et al.   De novo demonstration and co-localization of free-radical production and apoptosis formation in kidney subjected to ischemia/reperfusion . J Am Soc Nephrol . 2001;12:973
  3. Pincemail J , Defraigne JO , Franssen C , et al.   Evidence for free radical formation during human kidney transplantation . Free Rad Biol Med . 1993;15:343
  4. Colpaert EE , Lefebvre RA . Interaction of hypoxanthine/xanthine oxidase with nitrergic relaxation in the porcine gastric fundus . Br J Pharmacol . 2000;130:359
  5. Komada F , Nishiguchi K , Tanigawara Y , et al.   Effects of secretable SOD delivered by genetically modified cells on xanthine/xanthine oxidase and paraquat-induced cytotoxicity in vitro . Biol Pharm Bull . 1999;22:846
  6. Radi R , Rubbo H , Bush K , et al.   Xanthine oxidase binding to glycosaminoglycans (kinetics and superoxide dismutase interactions of immobilized xanthine oxidase-heparin complexes) . Arch Biochem Biophys . 1997;339:125
  7. Smoleński RT , Skladanowski AC , Perko M , et al.   Adenylate degradation products release from the human myocardium during open heart surgery . Clin Chim Acta . 1989;182:63
  8. Smolenski RT , Lachno DR , Ledingham SJ , et al.   Determination of sixteen nucleotides, nucleosides and bases using high-performance liquid chromatography and its application to the study of purine metabolism in hearts for transplantation . J Chromatogr . 1990;527:414
  9. Hower R , Minor Th , Scneeberger H , et al.   Assessment of oxygen radicals during transplantation—effect of radical scavenger . Transpl Int . 1996;9:479
  10. Grinyo JM . Role of ischemia-reperfusion injury in the development of chronic renal allograft damage . Transplant Proc . 2001;33:3741
  11. Sermet A , Tasdemir N , Deniz B . Time-dependent changes in superoxide dismutase, catalase, xanthine dehydrogenase and oxidase activities in focal cerebral ischaemia . Cytobios . 2000;102:157
  12. Yoshikawa T , Minamiyama Y , Ichikawa H . Role of lipid peroxidation and antioxidants in gastric mucosal injury induced by the hypoxanthine-xanthine oxidase system in rats . Free Radic Biol Med . 1997;23:243
  13. Dowell FJ , Hamilton CA , McMurray J . Effects of a xanthine oxidase/hypoxanthine free radical and reactive oxygen species generating system on endothelial function in New Zealand white rabbit aortic rings . J Cardiovasc Pharmacol . 1993;22:792
  14. Foltz RJ , Carpo JD . Extracellular superoxide dismutase (SOD3) (tissue-specific expression, genomic characterization and computer-assisted sequence analysis of human EC SOD gene) . Genomics . 1994;22:162
  15. Marklund SL . Regulation by cytokines of extracellular superoxide dysmutase and other superoxide dismutase isoenzymes in fibroblasts . J Biol Chem . 1992;267:6696
  16. Stralin P , Marklund SL . Effects of oxidative stress on expression of extracellular superoxide dysmutase, CuZn-superoxide dismutase and Mn-superoxide dismutase in human dermal fibroblasts . Biochem J . 1994;298:347

 The study was sponsored by the State Committee for Scientific Research of Poland (grant 3 P05C 073 24p05).

PII: S0041-1345(05)01442-9

doi: 10.1016/j.transproceed.2005.11.083

Transplantation Proceedings
Volume 38, Issue 1 , Pages 35-38 , January 2006

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