Donor intracranial bleeding is associated with advanced transplant coronary vasculopathy: Evidence from intravascular ultrasound

Yamani, M.H.; Erinc, K.; Starling, R.C.; Young, J.B.; Ratliff, N.B.; Cook, D.J.; Crowe, T.; Hobbs, R.; Rincon, G.; Bott-Silverman, C.; Bennett, R.; Smedira, N.; Tuzcu, E.M.

doi:10.1016/j.transproceed.2004.11.069

« Previous Next »Transplantation Proceedings
Volume 36, Issue 9 , Pages 2564-2566, November 2004

Donor intracranial bleeding is associated with advanced transplant coronary vasculopathy: Evidence from intravascular ultrasound

M.H. Yamani
- Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
- Address reprint requests to M.H. Yamani, MD, Cleveland Clinic Foundation, Cardiovascular Medicine, F25, 9500 Euclid Avenue, Cleveland, OH 44195
K. Erinc
- Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
R.C. Starling
- Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
J.B. Young
- Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
N.B. Ratliff
- Department of Anatomic Pathology, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
D.J. Cook
- Allogen Laboratory, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
T. Crowe
- Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
R. Hobbs
- Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
G. Rincon
- Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
C. Bott-Silverman
- Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
R. Bennett
- Department of Cardiothoracic Surgery, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
N. Smedira
- Department of Cardiothoracic Surgery, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States
E.M. Tuzcu
- Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States

Abstract

Objectives

We evaluated the impact of spontaneous intracranial bleeding (ICB) in the donor on transplant coronary vasculopathy using serial intravascular ultrasound examinations.

Materials and methods

Between January 1995 and December 2000, 72 recipients underwent cardiac transplantation from donors who had experienced spontaneous ICB (ICB group). Their findings using serial intravascular ultrasound analysis at baseline (within 1 month) and 1 year after transplantation were compared with 90 recipients who had undergone transplantation from trauma donors (trauma group).

Results

Compared with the Trauma group, the ICB group showed increased coronary intimal thickness (0.55 ± 0.33 vs 0.39 ± 0.3 mm; P = .034), plaque volume (3.84 ± 2.5 vs 2.28 ± 1.65 mm³; P = .015) and plaque burden (7.4 vs 2%) at 1 year after transplantation.