Donor intracranial bleeding is associated with advanced transplant coronary vasculopathy: Evidence from intravascular ultrasound

Abstract

Objectives

We evaluated the impact of spontaneous intracranial bleeding (ICB) in the donor on transplant coronary vasculopathy using serial intravascular ultrasound examinations.

Materials and methods

Between January 1995 and December 2000, 72 recipients underwent cardiac transplantation from donors who had experienced spontaneous ICB (ICB group). Their findings using serial intravascular ultrasound analysis at baseline (within 1 month) and 1 year after transplantation were compared with 90 recipients who had undergone transplantation from trauma donors (trauma group).

Results

Compared with the Trauma group, the ICB group showed increased coronary intimal thickness (0.55 ± 0.33 vs 0.39 ± 0.3 mm; P = .034), plaque volume (3.84 ± 2.5 vs 2.28 ± 1.65 mm3; P = .015) and plaque burden (7.4 vs 2%) at 1 year after transplantation.

Conclusions

Donor spontaneous ICB is associated with significantly increased coronary vasculopathy.

a Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States

b Department of Anatomic Pathology, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States

c Allogen Laboratory, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States

d Department of Cardiothoracic Surgery, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation Cleveland, OH, United States

Address reprint requests to M.H. Yamani, MD, Cleveland Clinic Foundation, Cardiovascular Medicine, F25, 9500 Euclid Avenue, Cleveland, OH 44195

PII: S0041-1345(04)01349-1

doi:10.1016/j.transproceed.2004.11.069

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