Transplantation Proceedings
Volume 36, Issue 10 , Pages 3288-3294 , December 2004

Cryopreservation alters antigenicity of allografts in a porcine model of transplant vasculopathy

  • N. Solanes

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • Corresponding Author InformationAddress reprint requests to N. Solanes, Institut, de Malalties Cardiovasculars, Villarroel 170, Barcelona 08036, Spain
    • ,
  • M. Rigol

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • ,
  • M. Castellà

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • ,
  • E. Khabiri

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • ,
  • J. Ramı́rez

      Affiliations

    • Servei d'Anatomia Patològica, Hospital Clinic
    • ,
  • J. Segalés

      Affiliations

    • Centre de Recerca en Sanitat Animal, Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
    • ,
  • M. Roqué

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • ,
  • E. Agustı́

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • ,
  • F. Pérez-Villa

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • ,
  • E. Roig

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • ,
  • J.L. Pomar

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • ,
  • G. Sanz

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer
    • ,
  • M. Heras

      Affiliations

    • Institut de Malalties Cardiovasculars, Institut d'Investigacions Biomèdiques Agustı́ Pi Sunyer

References 

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  5. Rigol M , Heras M , Martinez A , et al.  Changes in the cooling rate and medium improve the vascular function in cryopreserved porcine femoral arteries . J Vasc Surg . 2000;31:1018
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  7. Takamoto S , Nakajima S , Okita Y , et al.  Cryopreserved femoral arterial allografts for vascular access in hemodialysis . Transplant Proc . 1998;30:3917
  8. Kreitmann B , Riberi A , Zeranska M , et al.  Growth potential of aortic autografts and allografts: effects of cryopreservation and immunosuppression in an experimental model . Eur J Cardiothorac Surg . 1997;11:943
  9. Moriyama S , Utoh J , Sun L , et al.  Clinical controversy concerning the use of cryopreserved allografts in cardiovascular surgery . Transplant Proc . 2000;32:336
  10. Nataf P , Guettier C , Martinelli L , et al.  Cryopreserved small-diameter arterial allografts for arterial by-pass procedures: an experimental study . J Cardiovasc Surg (Torino) . 1995;36:79
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  13. Vischjager M , Van Gulik TM , Van Marle J , et al.  Function of cryopreserved arterial allografts under immunosuppressive protection with cyclosporine A . J Vasc Surg . 1996;24:876
  14. Mesa F , Serra JM , Herreros J . Vascular cryopreservation in microsurgery . J Reconstr Microsurg . 1997;13:245
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  16. Komorowska-Timek E , Zhang F , Shi DY , et al.  Effect of cryopreservation on patency and histological changes of arterial isogeneic and allogeneic grafts in the rat model . Ann Plast Surg . 2002;49:404
  17. Vischjager M , Van Gulik TM , De Kleine RH , et al.  Experimental arterial allografting under low and therapeutic dosages of cyclosporine for immunosuppression . Transplantation . 1996;61:1138
  18. Fellstrom B , Backman U , Larsson E , et al.  Immunologic and nonimmunologic risk factors of chronic rejection . Transplant Proc . 1999;31:1304
  19. Hayry P . Chronic rejection: an update on the mechanism . Transplant Proc . 1998;30:3993
  20. Plissonnier D , Nochy D , Poncet P , et al.  Sequential immunological targeting of chronic experimental arterial allograft . Transplantation . 1995;60:414
  21. Schmitz-Rixen T , Megerman J , Colvin RB , et al.  Immunosuppressive treatment of aortic allografts . J Vasc Surg . 1988;7:82
  22. Auch-Schwelk W , Bossaller C , Gotze S , et al.  Endothelial and vascular smooth muscle function after chronic treatment with cyclosporin A . J Cardiovasc Pharmacol . 1993;21:435
  23. Bujan J , Bellon JM , Jurado F , et al.  Assessment of cyclosporine A-induced ultrastructural changes in vascular wall using an experimental arterial autograft model . Histol Histopathol . 1995;10:567
  24. Geerling RA , de Bruin RW , Scheringa M , et al.  Suppression of acute rejection prevents graft arteriosclerosis after allogeneic aorta transplantation in the rat . Transplantation . 1994;58:1258
  25. Richter MH , Richter H , Barten M , et al.  Cyclosporin A does not enhance the development of transplant vasculopathy: experimental study in a rat cardiac transplant model . Transplant Proc . 2002;34:1479

 Financed in part by a grant from Dirección General de Investigación Cientı́fica y Técnica (DGICYT 1999), by a grant from Fundació la Marató de TV3 (004210, 2000) and by Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Red RECAVA.

PII: S0041-1345(04)01241-2

doi: 10.1016/j.transproceed.2004.10.053

Transplantation Proceedings
Volume 36, Issue 10 , Pages 3288-3294 , December 2004

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