Serum LECT2 level as a prognostic indicator in acute liver failure

Sato, Y.; Watanabe, H.; Kameyama, H.; Kobayashi, T.; Yamamoto, S.; Takeishi, T.; Hirano, K.; Oya, H.; Nakatsuka, H.; Watanabe, T.; Kokai, H.; Yamagoe, S.; Suzuki, K.; Oya, K.; Kojima, K.; Hatakeyama, K.

doi:10.1016/j.transproceed.2004.07.007

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Volume 36, Issue 8 , Pages 2359-2361, October 2004

Serum LECT2 level as a prognostic indicator in acute liver failure

Y. Sato
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
- Address reprint requests to Yoshinobu Sato, MD, PhD, Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata City, Niigata 951-8510, Japan
H. Watanabe
- Center of Molecular Biosciences University of Ryukyus (H.W.), Niigata, Japan
H. Kameyama
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
T. Kobayashi
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
S. Yamamoto
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
T. Takeishi
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
K. Hirano
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
H. Oya
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
H. Nakatsuka
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
T. Watanabe
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
H. Kokai
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
S. Yamagoe
- Laboratory of Biodefence (S.Y., K.S.), National Institute of Infectious Disease Niigata, Japan
K. Suzuki
- Laboratory of Biodefence (S.Y., K.S.), National Institute of Infectious Disease Niigata, Japan
K. Oya
- Medical & Biological Laboratories (MBL) Co, Ltd (K.O., K.K.), Niigata, Japan
K. Kojima
- Medical & Biological Laboratories (MBL) Co, Ltd (K.O., K.K.), Niigata, Japan
K. Hatakeyama
- Department of Regenerative and Transplant Medicine, Division of Digestive and General Surgery (Y.S., H.K., T.K., S.Y., T.T., K.H., H.O., H.N., T.W., H.K., K.H.), Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan

Abstract

In the present study, we investigated the relationship between serum leukocyte cell-derived chemotaxin2 (LECT2) levels and liver function in patients with acute liver failure, and its use as a prognostic indicator. We studied six acute liver failure patients (two women, four men; 49.8 ± 20.7 years old) admitted to our hospital in 2002. These patients had diagnoses of fulminant hepatitis due to acute liver failure (1) from congestive heart failure; (2) from portal venous gas, and (3) from postoperative disseminated intravascular coagulation (DIC). We measured serum LECT2, GOT, and GPT levels, the last two being inversely proportionate to the serum LECT2 levels. When the serum GPT levels peaked, the serum LECT2 levels were the lowest. When the liver function recovered, serum LECT2 levels increased. Three of four patients died due to liver failure, one to congestive heart failure. Maximum serum LECT2 levels among the expired group were significantly lower than those among the alive group (0.96 ± 0.8 ng/mL vs 12.9 ± 4.3 ng/mL). Serum LECT2 levels may be a prognostic indicator of recovery from liver failure. The present study suggests that in clinical medicine LECT2 participates in regeneration after injury of hepatocytes.