Transplantation Proceedings
Volume 36, Issue 6 , Pages 1747-1752 , July 2004

The impact of thymoglobulin on renal function and calcineurin inhibitor initiation in recipients of orthotopic liver transplant: A retrospective analysis of 298 consecutive patients

  • J.I. Tchervenkov

      Affiliations

    • Department of Surgery, Section of Transplantation, Royal Victoria Hospital, McGill University Health Center, Montreal
    • Corresponding Author InformationAddress reprint requests to Jean I. Tchervenkov, MD, Director of Transplantation, 687 Pine Ave. West, S 10.26, Montreal, Quebec H3A 1A1 Canada
    • ,
  • G.N. Tzimas

      Affiliations

    • Department of Surgery, Section of Transplantation, Royal Victoria Hospital, McGill University Health Center, Montreal
    • ,
  • M. Cantarovich

      Affiliations

    • Department of Medicine, Royal Victoria Hospital, McGill University Health Center, Montreal, Quebec, Canada
    • ,
  • J.S. Barkun

      Affiliations

    • Department of Surgery, Section of Transplantation, Royal Victoria Hospital, McGill University Health Center, Montreal
    • ,
  • P. Metrakos

      Affiliations

    • Department of Surgery, Section of Transplantation, Royal Victoria Hospital, McGill University Health Center, Montreal

References 

  1. US Multicenter FK-506 Liver Study Group . A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression in liver transplantation . N Engl J Med . 1994;331:1110
  2. Platz KP , Mueller AR , Blumhardt G , et al.  Nephrotoxicity following orthotopic liver transplantation: a comparison between cyclosporine and FK506 . Transplantation . 1994;58:170
  3. De Mattos AM , Olyai AJ , Bennett WM . Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future . Am J Kid Dis . 2000;35:333
  4. McCauley J , Van Thiel DH , Starzl TE , et al.  Acute and chronic renal failure in liver transplantation . Nephron . 1990;55:121
  5. Lynn M , Abreo K , Zibari G , et al.  End stage renal disease in liver transplants . Transplantation . 2001;15(suppl 15):66
  6. Cantarovich M , Tzimas GN , Barkun J , et al.  Efficacy of mycophenolate mofetil combined with very low-dose cyclosporine microemulsion in long-term liver transplant recipients with renal dysfunction . Transplantation . 2003;76:98
  7. Reich DJ , Clavien PA , Kim-Schluger L , et al.  An open label, active controlled study to evaluate the use of mycophenolate mofetil (cellcept) in post liver transplant patients with renal impairment who are currently on cyclosporine/FK506 . Am J Transplant 1 . 2001;(suppl 1):203
  8. Berlakovich GA , Windhager T , Wamser P , et al.  Limits of MMF in liver transplantation—discontinuation of a CyA withdrawal trial . Am J Transplant 1 . 2001;(suppl 1):309
  9. Cosimi AB , Jenkins RL , Rohrer RJ , et al.  A randomized clinical trial of prophylactic OKT3 monoclonal antibody in liver allograft recipients . Arch Surg . 1990;125:781
  10. Farges O , Ericzon BG , Bresson-Handi S , et al.  A randomized trial of OKT3-based vs. cyclosporine-based immunoprophylaxis after liver transplantation . Transplantation . 1994;58:891
  11. Heffron TG , Smallwood GA , de Vera ME , et al.  Daclizumab induction in liver transplant recipients . Transplantation . 2001;83:1527
  12. Emre S , Gondolesi G , Polat K , et al.  Use of daclizumab as initial immunosuppression in liver transplant recipients with impaired renal function . Liver Transpl . 2001;7:220
  13. Gaber AO , First MR , Tesi RJ , et al.  Results of the double-blind, randomized, multicenter, phase III clinical trial of thymoglobulin versus atgam in the treatment of acute graft rejection episodes after renal transplantation . Transplantation . 1998;66:29
  14. Tchervenkov J , Flemming C , Guttmann RD , et al.  Use of thymoglobulin induction therapy in the prevention of acute graft rejection episodes following liver transplantation . Transplant Proc . 1997;29:13S
  15. Bilbao I , Charco R , Balsells J , et al.  Risk factors for acute renal failure requiring dialysis after liver transplantation . Clin Transplant . 1998;12:123
  16. Fisher NC , Nightingale PG , Gunson BK , et al.  Chronic renal failure following liver transplantation: a retrospective analysis . Transplantation . 1998;66:59
  17. Nuno J , Cuervas-Mons V , Vicente E , et al.  Renal failure after liver transplantation: analysis of risk factors in 139 liver transplant recipients . Transplant Proc . 1995;27:2319
  18. Pascual E , Gomez-Arnau J , Pensado A , et al.  Incidence and risk factors of early acute renal failure in liver transplant recipients . Transplant Proc . 1993;25:1837
  19. Gonwa TA , Mai ML , Melton LB , et al.  End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy . Transplantation . 2001;72:1934
  20. Platz KP , Mueller AR , Blumhardt G , et al.  Nephrotoxicity following orthotopic liver transplantation: a comparison between cyclosporine and FK506 . Transplantation . 1994;58:170
  21. Wheatley HC , Datzman M , Williams JW , et al.  Long-term effects of cyclosporine on renal function in liver transplant recipients . Transplantation . 1987;43:641
  22. Wiesner R , Rabkin J , Klintmalm G , et al.  A randomized double-blind comparative study of mycophenolate mofetil and azathioprine in combination with cyclosporine and corticosteroids in primary liver transplant recipients . Liver Transpl . 2001;7:442
  23. The Tricontinental Mycophenolate Mofetil Renal Transplanatation Study . A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation . Transplantation . 1996;61:1029
  24. Gonwa TA , Mai ML , Melton LB , et al.  End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy . Transplantation . 2001;72:1934
  25. Ishani A , Ertuck S , Hertz MI , et al.  Predictors of renal function following lung or heart–lung transplantation . Kidney Int . 2002;61:2228

 This work was supported by the Lois and Byron Dolgin Liver Transplant Fellowship, and by the Michael Cohen Liver Transplant Fellowship, of the Royal Victoria Liver Transplant Fund.

PII: S0041-1345(04)00679-7

doi: 10.1016/j.transproceed.2004.06.014

Transplantation Proceedings
Volume 36, Issue 6 , Pages 1747-1752 , July 2004

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