Transplantation Proceedings
Volume 36, Issue 6 , Pages 1753-1756 , July 2004

Cyclosporine levels at 2 hours after dose and body mass index in relation to graft function in renal transplant patients treated with azathioprine or mycophenolate mofetil

  • I. Konstadinidou

      Affiliations

    • Transplant Center (I.K., N.G., S.L., A.K., C.P.S., J.N.B.)
    • ,
  • N. Giapraka

      Affiliations

    • Transplant Center (I.K., N.G., S.L., A.K., C.P.S., J.N.B.)
    • Corresponding Author InformationAddress reprint requests to Dr Nektaria Giapraka, Department of Nephrology, Laiko Hospital, 17 St. Thomas Street, GR-11527 Athens, Greece
    • ,
  • S. Lionaki

      Affiliations

    • Transplant Center (I.K., N.G., S.L., A.K., C.P.S., J.N.B.)
    • ,
  • D. Kyriaki-Manolaraki

      Affiliations

    • Department of Radionuclear Medicine (D.K.-M.), Laiko Hospital, Athens, Greece
    • ,
  • A. Kostakis

      Affiliations

    • Transplant Center (I.K., N.G., S.L., A.K., C.P.S., J.N.B.)
    • ,
  • C.P. Stathakis

      Affiliations

    • Transplant Center (I.K., N.G., S.L., A.K., C.P.S., J.N.B.)
    • ,
  • J.N. Boletis

      Affiliations

    • Transplant Center (I.K., N.G., S.L., A.K., C.P.S., J.N.B.)

References 

  1. Opelz G , Dohler B . Cyclosporine and long-term kidney graft survival . Transplantation . 2001;72:1267
  2. Holt DW , Johnston A . Cyclosporin monitoring (its role in autoimmune indications) . J Autoimmun . 1992;5(suppl A):177
  3. Johnston A , Holt DW . Concentration-controlled trials. What does the future hold? . Clin Pharmacokinet . 1995;28:93
  4. Johnston A , Holt DW . Immunosuppressant drugs—the role of therapeutic drug monitoring . Br J Clin Pharmacol . 2001;52(suppl 1):61S
  5. Vanrenterghem YF . Tailoring immunosuppressive therapy for renal transplant recipients . Pediatr Transplant . 2001;5:467
  6. Meier-Kriesche HU , Arndorfer JA , Kaplan B . The impact of body mass index on renal transplant outcomes significant independent risk factor for graft failure and patient death . Transplantation . 2002;73:70
  7. Halme L , Eklund B , Kyllonen L , et al.  Is obesity still a risk factor in renal transplantation? . Transplant Int . 1997;10:284
  8. Meier-Kriesche HU , Vaghela M , Thambuganipalle R , et al.  The effect of body mass index on long-term renal allograft survival . Transplantation . 1999;68:1294
  9. Merion RM , Twork AM , Rosenberg L , et al.  Obesity and renal transplantation . Surg Gynecol Obstet . 1991;172:367
  10. Drafts HH , Anjum MR , Wynn JJ , et al.  The impact of pretransplant obesity on renal transplant outcomes . Clin Transplant . 1997;11:493
  11. Kahan B . Established immunosuppressive drugs (clinical and toxic effects) . In:  Kahan B ,  Ponticelli C editor. Principles and Practice of Renal Transplantation . London: Martin Dunitz; 2000;p. 349
  12. Shah MB , Martin JE , Schroeder TJ , et al.  The evaluation of the safety and tolerability of two formulations of cyclosporine (Neoral and Sandimmune. A meta-analysis) . Transplantation . 1999;67:1411
  13. Belitsky P , Dunn S , Johnston A , et al.  Impact of absorption profiling on efficacy and safety of cyclosporine therapy in transplant recipients . Clin Pharmacokinet . 2000;39:117
  14. Friman S , Backman L . A new microemulsion formulation of cyclosporin (pharmacokinetic and clinical features) . Clin Pharmacokinet . 1996;30:181
  15. Taesch S , Niese D . Safety and tolerability of a new oral formulation of a new oral formulation of cyclosporine A, Sandimmun Neoral, in renal transplant patients . Transplant Int . 1994;7(suppl 1):S263
  16. Primmett DR , Levine M , Kovarik JM , et al.  Cyclosporine monitoring in patients with renal transplants (two- or three-point methods that estimate area under the curve are superior to trough levels in predicting drug exposure) . Ther Drug Monit . 1998;20:276
  17. Wacke R , Rohde B , Enger G , et al.  Comparison of several approaches of therapeutic drug monitoring of cyclosporine A based on individual pharmacokinetics . Eur J Clin Pharmacol . 2000;56:43
  18. Bumgardner GL , Henry ML , Elkhammas E , et al.  Obesity as a risk factor after combined pancreas/kidney transplantation . Transplantation . 1995;60:1426

PII: S0041-1345(04)00673-6

doi: 10.1016/j.transproceed.2004.06.008

Transplantation Proceedings
Volume 36, Issue 6 , Pages 1753-1756 , July 2004

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