Transplantation Proceedings
Volume 36, Issue 3 , Pages 631-637 , April 2004

Midterm results of a prospective randomized comparison of two different rabbit-antithymocyte globulin induction therapies after heart transplantation

  • L.S De Santo

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • Corresponding Author InformationAddress reprint requests to Luca Salvatore De Santo, Viale Colli Aminei 491, 80129 Naples, Italy
    • ,
  • A Della Corte

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • G Romano

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • C Amarelli

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • F Onorati

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • M Torella

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • M De Feo

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • C Marra

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • C Maiello

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • B Giannolo

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • R Casillo

      Affiliations

    • Chair of Internal Medicine, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • E Ragone

      Affiliations

    • Chair of Internal Medicine, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • M Grimaldi

      Affiliations

    • Chair of Internal Medicine, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • R Utili

      Affiliations

    • Chair of Internal Medicine, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy
    • ,
  • M Cotrufo

      Affiliations

    • Department of Cardio-Thoracic and Respiratory Sciences, Service of Infectivological and Transplant Medicine, Second University of Naples, V Monaldi Hospital, Naples, Italy

References 

  1. Hosenpud JD, Bennet LE, Keck BM. The Registry of the International Society for Heart and Lung Transplantation (seventeenth official report—2000). J Heart Lung Transplant. 2000;19:909
  2. Joun R, Rajasinghe HA, Chen JM, et al.  Long-term outcomes after cardiac transplantation (an experience based on different eras of immunosuppressive therapy). Ann Thorac Surg. 2001;72:440
  3. Spratt P, Esmore D, Baron D, et al.  Effects of low-dose cyclosporin A on toxicity and rejection in cardiac transplantation. Transplant Proc. 1987;19:2847
  4. Carrier M, Jenicek M, Pelletier LC. Value of monoclonal antibody OKT3 in solid organ transplantation (a meta-analysis). Transplant Proc. 1992;24:2586
  5. Carrier M, White M, Perrault LP, et al.  A 10-year experience with intravenous thymoglobuline in induction of immunosuppression following heart transplantation. J Heart Lung Transplant. 1999;18:1218
  6. Bonnefoy-Berard N, Revillard JP. Mechanisms of immunosuppression induced by antithymocyte globulins and OKT3. J Heart Lung Transplant. 1996;15:435
  7. Genestier L, Fournel S, Flacher M, et al.  Induction of Fas(Apo-1, CD95)-mediated apoptosis of activated lymphocytes by policlonal antithymocyte globulins. Blood. 1998;91:2360
  8. Beaufigeau M, Dumesnil D, Carrier M, et al.  Seven-year experience with rabbit antithymocyte globulin after cardiac transplantation at the Montreal Heart Institute. Transplant Proc. 1997;29:10S
  9. Lavee J, Bar-Zohar D, Har-Zahav Y, et al.  Immunosuppression induction with rabbit antithymocyte globulin in heart transplantation patients (6-year experience at the Sheba Medical Center). Transplant Proc. 2000;32:737
  10. Chien NC, Lin FL, Chou NK, et al.  Rabbit antithymocyte globulin induction immunosuppression in heart transplantation. Transplant Proc. 2000;32:2380
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  12. Billingham ME, Cary NRB, Hammond ME, et al.  A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection (heart rejection study group). J Heart Transplant. 1990;9:587
  13. Kormos RL, Herlan DB, Armitage JM, et al.  Monoclonal versus polyclonal antibody therapy for prophylaxis against rejection after heart transplantation. J Heart Transplant. 1990;9:1
  14. Renlund DG, O'Connell JB, Gilbert EM, et al.  A prospective comparison of murine monoclonal CD-3 (OKT3) antibody-based and equine antithymocyte globulin-based rejection prophylaxis in cardiac transplantation. Decreased rejection and less corticosteroid use with OKT3. Transplantation. 1989;47:599
  15. Swinnen LJ, Costanzo-Nordin MR, Fisher SG, et al.  Increased incidence of lymphoproliferative disorders after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients. N Engl J Med. 1990;323:1723
  16. Mcdonalnd PS, Mundy J, Keogh AM, et al.  A prospective randomised study of prophylactic OKT3 versus equine antithymocyte globulin after heart transplantation. Increased morbidity with OKT3. Transplantation. 1993;55:110
  17. Bourdage JS, Hamlin DM. Comparative polyclonal antithymocyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cytometry. Transplantation. 1995;59:1194
  18. Krogsgaard K, Boesgaard S, Aldershvile J, et al.  Cytomegalovirus infection rate among heart transplant patients in relation to anti-thymocyte immunoglobulin induction therapy. Scand J Infect Dis. 1994;26:239
  19. Leger PH, Pavie A: Comparison de deux globulines antithymocytaires, Fresenius et Merieux, en tranplantation cardiaque. In Cabrol C, Gandjbakhch I, Pavie A (eds): Les Journees Hospital de la Pitie. Paris: 1994. 1995, p 103
  20. Zuckermann AO, Grimm M, Czerny M, et al.  Improved long-term results with thymoglobuline induction therapy after cardiac transplantation; a comparison of two different rabbit-antithymocyte globulines. Transplantation. 2000;69:1890
  21. Müller TF. Long-term T cell dynamics following the use of polyclonal and monoclonal antibodies. Graft. 1999;21:15
  22. Balk AH, Weimar W, Rothbarth PH, et al.  Passive immunization against cytomegalovirus in allograft recipients. The Rotterdam heart transplant program experience. Infection. 1993;21:195
  23. Gamadia LE, Remmerswaal EB, Weel JF, et al. Primary immune responses to human cytomegalovirus: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV-disease. Blood 101:2686, 2003
  24. Sester M, Sester U, Gartner BC, et al.  Dominance of virus-specific CD8 T cells in human primary cytomegalovirus infection. J Am Soc Nephrol. 2002;13:2577
  25. Essa S, Pacsa AS, Raghupathy R, et al.  CD4(+) T cell levels are decreased during active CMV infection in kidney transplant recipients. FEMS Immunol Med Microbiol. 2002;34:17
  26. John R, Rajasinghe H, Chen JM, et al.  Impact of current management practices on early and late death in more than 500 consecutive cardiac transplant recipients. Ann Surg. 2000;232:302
  27. McGiffin DC, Kirklin JK, Naftel DC, et al.  Competing outcomes after heart transplantation (a comparison of eras and outcomes). J Heart Lung Transplant. 1997;16:190
  28. Gao SZ, Schroeder JS, Aldermann EL, et al.  Prevalence of accelerated coronary artery disease in heart transplant survivors (comparison of cyclosporine and azathioprine regimens). Circulation. 1989;80:S100
  29. Koskinen PK, Nieminen MS, Krogerus LA, et al.  Cytomegalovirus infection accelerates cardiac allograft vasculopathy (correlation between angiographic and endomyocardial biopsy findings in heart transplant recipients). Transplant Int. 1993;6:341
  30. Zerbe T, Uretsky B, Kormos R, et al.  Graft atherosclerosis (effects of cellular rejection and human lymphocyte antigen). J Heart Lung Transplant. 1992;11:S104

PII: S0041-1345(04)00197-6

doi: 10.1016/j.transproceed.2004.02.053

Transplantation Proceedings
Volume 36, Issue 3 , Pages 631-637 , April 2004

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