Transplantation Proceedings
Volume 36, Issue 2, Supplement , Pages S261-S266 , March 2004

Learning and new discovery with cyclosporine in the cambridge-king's programme: a personal view

  • R. Williams

      Affiliations

    • Institute of Hepatology, University College of London, London, UK
    • Corresponding Author InformationAddress reprint requests to Professor Roger Williams, Director, Institute of Hepatology, University College London, 69-75 Chenies Mews, London, WC1E 6HX, UK.

References 

  1. Calne RY, Williams R. Liver transplantation in man. I. Observations on technique and organization in five cases. Br Med J. 1968;4:535
  2. Calne RY, Williams R, Dawson JL, et al.  Liver transplantation in man. II. A report of two orthotopic liver transplants in adult recipients. Br Med J. 1968;4:541
  3. Williams R, Calne RY, Ansell ID, et al.  Liver transplantation in man—3, studies of liver function, histology, and immunosuppressive therapy. Br Med J. 1969;3:12
  4. Flute PT, Rake MO, Williams R, et al.  Liver transplantation in man—IV, haemorrhage and thrombosis. Br Med J. 1969;3:20
  5. Eddleston AL, Smith MG, Dominguez J, et al.  An immunological approach to the diagnosis of rejection of liver transplants. Gut. 1969;10:1051
  6. Parkes JD, Murray-Lyon IM, Williams R. Neuropsychiatric and electro-encephalographic changes after transplantation of the liver. Q J Med. 1970;39:515
  7. Starzl TE: The Puzzel People. Pittsburgh: University of Pittsburgh Press; 1992
  8. Calne RY, Thiru S, McMaster P, et al.  Cyclosporin A in patients receiving renal allografts from cadaver donors. 1978. J Am Soc Nephrol. 1998;9:175
  9. Calne RY, Rolles K, White DJ, et al.  Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs (32 kidneys, 2 pancreases, and 2 livers). Lancet. 1979;2:1033
  10. Calne RY, White DJ, Evans DB, et al.  Cyclosporin A in cadaveric organ transplantation. Br Med J (Clin Res Ed). 1981;282:934
  11. Powell-Jackson PR, Young B, Calne RY, et al.  Nephrotoxicity of parenterally administered cyclosporine after orthotopic liver transplantation. Transplantation. 1983;36:505
  12. Williams R, Blackburn A, Neuberger J, et al.  Long-term use of cyclosporin in liver grafting. Q J Med. 1985;57:897
  13. O'Grady JG, Forbes A, Rolles K, et al.  An analysis of cyclosporine efficacy and toxicity after liver transplantation. Transplantation. 1988;45:575
  14. Keating JJ, Neuberger J, Clarke M, et al.  Long-term effects of cyclosporin on renal function in liver transplant recipients. Hepatol. 1985;5:975A
  15. Dische FE, Neuberger J, Keating J, et al.  Kidney pathology in liver allograft recipients after long-term treatment with cyclosporin A. Lab Invest. 1988;58:395
  16. Tredger JM, Steward CM, Williams R. Cyclosporine blood levels—an evaluation of radioimmunoassay with selective monoclonal or polyclonal antibodies and high-performance liquid chromatography in liver transplant recipients. Transplantation. 1988;46:681
  17. Naoumov NV, Tredger JM, Steward CM, et al.  Cyclosporin A pharmacokinetics in liver transplant recipients in relation to biliary T-tube clamping and liver dysfunction. Gut. 1989;30:391
  18. Arnold JC, O'Grady JG, Tredger JM, et al.  Effects of low-dose prednisolone on cyclosporine pharmacokinetics in liver transplant recipients (radioimmunoassay with specific and non-specific monoclonal antibodies). Eur J Clin Pharmacol. 1990;39:257
  19. Tredger JM, Grevel J, Naoumov N, et al.  Cyclosporine pharmacokinetics in liver transplant recipients (evaluation of results using both polyclonal radioimmunoassay and liquid chromatographic analysis). Eur J Clin Pharmacol. 1991;40:513
  20. Hossein-Nia M, Devlin JJ, Fagbohun M, et al.  Urinary proteins as a marker of drug-induced renal damage following treatment with cyclosporine or FK 506. Transplant Proc. 1991;23:3150
  21. Tredger JM, Gonde CE, Williams R. Monitoring cyclosporine in liver-transplant recipients (effects of clinical status on the performance of two monoclonal antibody-based methods). Clin Chem. 1992;38:108
  22. Cakaloglu Y, Marinos G, Marsden J, et al.  Localization of cyclosporin A absorption in rat small bowel and the effect of bile. Clin Sci (Lond). 1993;84:675
  23. Al-Quaiz MN, O'Grady JG, Tredger JM, et al.  Variable effect of ursodeoxycholic acid on cyclosporin absorption after orthotopic liver transplantation. Transpl Int. 1994;7:190
  24. Bird GL, Meadows J, Goka J, et al.  Cyclosporin-associated akinetic mutism and extrapyramidal syndrome after liver transplantation. J Neurol Neurosurg Psychiatry. 1990;53:1068
  25. Otto MG, Mayer AD, Clavien PA, et al: Randomized trial of cyclosporine microemulsion (neoral) versus conventional cyclosporine in liver transplantation: MILTON study. Multicentre International Study in Liver Transplantation of Neoral. Transplantation 66:1632, 1998 Erratum in: (Transplantation 67:1386, 1999)
  26. European FK506 Multicentre Liver Study Group. Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. Lancet. 1994;344:423
  27. O'Grady JG, Burroughs A, Hardy P, et al.  Tacrolimus versus microemulsified ciclosporin in liver transplantation (the TMC randomised controlled trial). Lancet. 2002;360:1119
  28. Ojo AO, Held PJ, Port FK, et al.  Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med. 2003;349:931
  29. Fabrizi F, Aucella F, Lunghi G, et al.  HCV-associated renal diseases after liver transplantation. Int J Artif Organs. 2003;26:452

PII: S0041-1345(04)00008-9

doi: 10.1016/j.transproceed.2004.01.007

Transplantation Proceedings
Volume 36, Issue 2, Supplement , Pages S261-S266 , March 2004

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