Transplantation Proceedings
Volume 36, Issue 2, Supplement , Pages S437-S441 , March 2004

New concepts in cyclosporine pharmacokinetic and dynamic monitoring: the impact of concomitant immunosuppression on target C2 concentrations

  • M Brunet

      Affiliations

    • Departments of Servei de Farmacologia y Toxicologia (M.B., O.J., E.V., V.F.), IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    • Corresponding Author InformationAddress reprint requests to Mercè Brunet, Laboratori de Farmacologia, Centre de Diagnòstic Biomèdic, Hospital Clinic de Barcelona, C/ Villarroel 170, 08036 Barcelona, Spain.
    • ,
  • O Millán

      Affiliations

    • Servei d' Immunologia (O.M., I.R., J.M.), IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    • ,
  • O Jiménez

      Affiliations

    • Departments of Servei de Farmacologia y Toxicologia (M.B., O.J., E.V., V.F.), IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    • ,
  • J.M Campistol

      Affiliations

    • Unitat de Transplantament Renal (J.M.C., F.O.), IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    • ,
  • E Vidal

      Affiliations

    • Departments of Servei de Farmacologia y Toxicologia (M.B., O.J., E.V., V.F.), IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    • ,
  • I Rojo

      Affiliations

    • Servei d' Immunologia (O.M., I.R., J.M.), IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    • ,
  • F Oppenheimer

      Affiliations

    • Unitat de Transplantament Renal (J.M.C., F.O.), IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    • ,
  • V Fortuna

      Affiliations

    • Departments of Servei de Farmacologia y Toxicologia (M.B., O.J., E.V., V.F.), IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    • ,
  • J Martorell

      Affiliations

    • Servei d' Immunologia (O.M., I.R., J.M.), IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain

References 

  1. Nashan B, Cole E, Levy G, et al.  Clinical validation studies of Neoral C2 monitoring (a review). Transplantation. 2002;73:S3
  2. Levy GA, Thervet E, Lake J, et al.  Patient management by Neoral C2 monitoring (an international consensus statement). Transplantation. 2002;73:S12
  3. Kung L, Halloran PF. Immunophilins may limit calcineurin inhibition by cyclosporine and tacrolimus at high drug concentrations. Transplantation. 2000;70:327
  4. Brunet M, Campistol JM, Millán O, et al.  Pharmacokinetic and pharmacodynamic correlations of cyclosporine in stable renal transplant patients (evaluation of long-term target C2). Int Immunopharmacol. 2003;3:987
  5. Beresini MH, Davalian D, Alexandre S, et al.  Evaluation of EMIT® cyclosporine assay for use with whole blood. Clin Chem. 1993;39:2235
  6. Brunet M, Martorell J, Oppenheimer F, et al.  Pharmacokinetics and pharmacodynamics of mycophenolic acid in stable renal transplant recipients treated with low doses of mycophenolate mofetil. Transpl Int. 2000;13:S301
  7. Li S, Yatscoff RW. Improved high-performance liquid chromatographic assay for the measurement of mycophenolic acid in human plasma. Transplant Proc. 1996;26:938
  8. Millán O, Brunet M, Campistol JM, et al.  Pharmacodynamic approach to immunosuppressive therapies using calcineurin inhibitors and mycophenolate mofetil. Clin Chem. 2003;49:11
  9. Fruman DA, Pai SY, Klee CB, et al.  Measurement of calcineurin phosphate activity in cell extracts. Methods. 1996;9:146
  10. Oellerich M, Armstrong VW. Two-hour cyclosporine concentration determination (appropriate tool to monitor neoral therapy). Ther Drug Monit. 2002;24:40
  11. Halloran PF, Kung L, Noujaim J. Calcineurin and the biological effect of cyclosporine and tacrolimus. Transplant Proc. 1998;30:2167
  12. Stein CM, Murray JJ, Wood AJJ. Inhibition of stimulated interleukin-2 production in whole blood (a practical measure of cyclosporine effect). Clin Chem. 1999;45:1477
  13. Batiuk TD, Pazderka F, Halloran PF. Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients. Transplantation. 1995;59:1400

PII: S0041-1345(03)01334-4

doi: 10.1016/j.transproceed.2003.12.023

Transplantation Proceedings
Volume 36, Issue 2, Supplement , Pages S437-S441 , March 2004

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