Transplantation Proceedings
Volume 36, Issue 2 , Pages 350-352 , March 2004

Intragraft heat shock protein-60 expression after small bowel transplantation in the mouse

  • M Oltean

      Affiliations

    • Department of Transplantation (M.O., G.D., G.K., M.O.), Sahlgrenska University Hospital, Göteborg, Sweden
    • Corresponding Author InformationAddress reprint requests to Dr Mihai Oltean, Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, 41345 Göteborg, Sweden.
    • ,
  • G Dindelegan

      Affiliations

    • Department of Transplantation (M.O., G.D., G.K., M.O.), Sahlgrenska University Hospital, Göteborg, Sweden
    • ,
  • G Kurlberg

      Affiliations

    • Department of Transplantation (M.O., G.D., G.K., M.O.), Sahlgrenska University Hospital, Göteborg, Sweden
    • ,
  • O Nilsson

      Affiliations

    • Department of Pathology (O.N.), Sahlgrenska University Hospital, Göteborg, Sweden
    • ,
  • A Karlsson-Parra

      Affiliations

    • Department of Clinical Immunology (A.K.-P.), Sahlgrenska University Hospital, Göteborg, Sweden
    • ,
  • M Olausson

      Affiliations

    • Department of Transplantation (M.O., G.D., G.K., M.O.), Sahlgrenska University Hospital, Göteborg, Sweden

References 

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  2. Trieb K, Dirnhofer S, Krumböck N, et al.  Heat shock protein expression in the transplanted human kidney. Transplant Int. 2001;14:281
  3. Mehta NK, Caroll M, Sykes DE, et al.  Heat shock protein 70 expression in native and heterotopically transplanted rat hearts. J Surg Res. 1997;70:151
  4. Schimke I, Lutsch G, Schernes U, et al.  Increased level of hsp27 but not of hsp72 in human heart allografts in relation to acute rejection. Transplantation. 2000;70:1694
  5. Pockley AG. Heat shock proteins, anti-heat shock protein reactivity and allograft rejection. Transplantation. 2001;71:1503
  6. Gallucci S, Matzinger P. Danger signals (SOS to the immune system). Curr Opin Immunol. 2001;13:114
  7. Bethke K, Staib F, Distler M, et al.  Different efficiency of heat shock proteins (HSP) to activate human monocytes and dendritic cells (superiority of HSP60). J Immunol. 2002;169:6141
  8. Flohe SB, Bruggemann J, Lendemans S, et al.  Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype. J Immunol. 2003;170:2340
  9. Moseley P. Stress proteins and the immune response. Immunopharmacology. 2000;48:299
  10. Basu S, Binder RJ, Suto R, et al.  Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol. 2000;12:1539
  11. Prohaszka Z, Singh M, Nagy K. Heat shock protein 70 is a potent activator of the human complement system. Cell Stress Chaperones. 2002;7:17
  12. Fleming SD, Starnes BW, Kiang JG, et al.  Heat stress protection against mesenteric I/R-induced alterations in the intestinal mucosa in rats. J Appl Physiol. 2002;92:2600
  13. Tsuruma T, Yagihashi A, Tarumi K, et al.  Induction of heat shock protein-73 reduces ischemia–reperfusion injury in rat small intestine. Transplant Proc. 1998;30:3449
  14. Ogita K, Hopkinson K, Nakao M, et al.  Stress responses in graft and native intestine after rat heterotopic small bowel transplantation. Transplantation. 2000;69:2273
  15. He G, Hart J, Thistlethwaite JR, et al.  Modified surgical model of paratopic small bowel transplantation in mice. J Surg Res. 1998;80:188
  16. Dindelegan G, Liden H, Kurlberg G, et al.  Laser-Doppler flowmetry is reliable for early diagnosis of small bowel acute rejection in the mouse. Microsurgery. 2003;23:233
  17. Birk OS, Gur SL, Elias D, et al.  The 60-kDa heat shock protein modulates allograft rejection. Proc Natl Acad Sci USA. 1999;96:5159
  18. Kol A, Bourcier T, Lichtman AH, et al.  Chlamydial and human heat shock protein 60s activate human endothelium, smooth muscle cells and macrophages. J Clin Invest. 1999;103:571
  19. Chen W, Syldath U, Bellmann K, et al.  Human 60-kDa heat shock protein (a danger signal to the innate immune system). J Immunol. 1999;162:3212
  20. Ferm MT, Soderstrom K, Jindal S, et al.  Induction of human hsp60 expression in monocytic cell lines. Int Immunol. 1992;4:305
  21. McDiarmid SV, Farmer DG, Kuniyoshi JS, et al.  The correlation of intragraft cytokine expression with rejection in rat small intestine transplantation. Transplantation. 1994;58:690
  22. Wasserberg N, Salgar SK, Yang D, et al.  Expression of MUC2 and MUC4 proteins and cytokines (early markers of intestinal graft rejection). Transplantation. 2003;75:1249

☆ Supported by the Swedish Research Council, Grant No. K2002-73X-12228-06B, and Sahlgrenska University Hospital. Mihai Oltean was partially supported by the Swedish Institute.

PII: S0041-1345(03)01333-2

doi: 10.1016/j.transproceed.2003.12.022

Transplantation Proceedings
Volume 36, Issue 2 , Pages 350-352 , March 2004

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