Transplantation Proceedings
Volume 36, Issue 2 , Pages 397-398 , March 2004

Viral interleukin-10 gene therapy to induce tolerance to solid organ transplants in mice

  • S.K Salgar

      Affiliations

    • Department of Surgery (S.K.S., D.Y., J.M., A.G.T.), University of Miami, Miami, Fl, USA
    • Corresponding Author InformationAddress reprint requests to Shashikumar K. Salgar, PhD, Director, Liver/GI Transplantation Research Laboratory, Department of Surgery, University of Miami School of Medicine, 1450 NW 10th Avenue, Room 2012, Miami, Florida 33136, USA.
    • ,
  • D Yang

      Affiliations

    • Department of Surgery (S.K.S., D.Y., J.M., A.G.T.), University of Miami, Miami, Fl, USA
    • ,
  • P Ruiz

      Affiliations

    • Department of Pathology (P.R.), University of Miami, Miami, Fl, USA
    • ,
  • J Miller

      Affiliations

    • Department of Surgery (S.K.S., D.Y., J.M., A.G.T.), University of Miami, Miami, Fl, USA
    • ,
  • A.G Tzakis

      Affiliations

    • Department of Surgery (S.K.S., D.Y., J.M., A.G.T.), University of Miami, Miami, Fl, USA

References 

  1. Moore KW, Vieira P, Fiorentino DF, et al.  Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRF1. Science. 1990;248:1230
  2. Moore KW, de Waal Malefyt R, Coffman RL, et al.  Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683
  3. Qin L, Chavin KD, Ding Y, et al.  Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival. J Immunol. 1996;156:2316
  4. Zuo Z, Wang C, Carpenter D, et al.  Prolongation of allograft survival with viral IL-10 transfection in a highly histoincompatible model of rat heart allograft rejection. Transplantation. 2001;71:686
  5. Adachi O, Yamato E, Kawamoto S, et al.  High-level expression of vIL-10 in cardiac allografts fails to prolong graft survival. Transplantation. 2002;74:1603
  6. Buonocore S, Van Meirvenne S, Demoor FX, et al.  Dendritic cells transduced with viral interleukin 10 or Fas ligand (no evidence for induction of allotolerance in vivo). Transplantation. 2002;73:S27

PII: S0041-1345(03)01320-4

doi: 10.1016/j.transproceed.2003.12.009

Transplantation Proceedings
Volume 36, Issue 2 , Pages 397-398 , March 2004

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